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Biology and Biochemistry

D-Index
125
Citations
53472
World Ranking
510
National Ranking
322

Overview

Vadivel Ganapathy is affiliated with Texas Tech University Health Sciences Center in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine, with a substantial focus on Molecular Biology, Biochemistry, Oncology, Cancer Research, and Physiology.

The scientist's main research topics include:

  • Amino Acid Enzymes and Metabolism
  • Drug Transport and Resistance Mechanisms
  • Cancer, Hypoxia, and Metabolism
  • Epigenetics and DNA Methylation
  • Metabolism and Genetic Disorders
  • Diet and metabolism studies
  • Iron Metabolism and Disorders

Vadivel Ganapathy has contributed extensively to scientific literature. Some notable recent papers include:

  • The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment (2020, Oncogene)
  • SLC6A14 and SLC38A5 Drive the Glutaminolysis and Serine-Glycine-One-Carbon Pathways in Cancer (2021, Pharmaceuticals)
  • Therapeutic application and construction of bilirubin incorporated nanoparticles (2020, Journal of Controlled Release)
  • Metabolic Signature of Warburg Effect in Cancer: An Effective and Obligatory Interplay between Nutrient Transporters and Catabolic/Anabolic Pathways to Promote Tumor Growth (2024, Cancers)
  • SLC6A14, a Na+/Cl−-coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling (2020, Biochemical Journal)

The scientist frequently publishes in the following venues:

  • Biochemical Journal (10 publications)
  • Cancer Research (6 publications)
  • Preprints.org (6 publications)
  • Cancers (5 publications)
  • Biophysical Journal (4 publications)

Vadivel Ganapathy collaborates with several coauthors on multiple projects, including:

  • Sathish Sivaprakasam
  • Yangzom D. Bhutia
  • Valeria Jaramillo-Martinez
  • Sabarish Ramachandran
  • Souad R. Sennoune

The research profile shows a significant engagement with cancer metabolism and transporter proteins, particularly focusing on amino acid transporters and metabolic pathways implicated in tumor growth and drug resistance mechanisms. The work integrates molecular biology techniques and biochemical analysis within medical research contexts.

Best Publications

  • Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

    Nagendra Singh;Ashish Gurav;Sathish Sivaprakasam;Evan Brady

  • Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.

    Sammanda Ramamoorthy;Andrea L. Bauman;Kim R. Moore;Hong Han

  • Expression cloning of a mammalian proton-coupled oligopeptide transporter

    You Jun Fei;You Jun Fei;Yoshikatsu Kanai;Yoshikatsu Kanai;Stephan Nussberger;Vadivel Ganapathy

  • The cystine/glutamate antiporter system xc- in health and disease: From molecular mechanisms to novel therapeutic opportunities

    Jan Lewerenz;Sandra J. Hewett;Ying Huang;Maria Lambros

  • Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

    Vadivel Ganapathy;Muthusamy Thangaraju;Puttur D. Prasad

  • GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon

    Muthusamy Thangaraju;Gail A. Cresci;Kebin Liu;Sudha Ananth

  • Human Intestinal H+/Peptide Cotransporter: CLONING, FUNCTIONAL EXPRESSION, AND CHROMOSOMAL LOCALIZATION

    Rong Liang;You-Jun Fei;Puttur D. Prasad;Sammanda Ramamoorthy

  • Death of retinal neurons in streptozotocin-induced diabetic mice.

    Pamela M. Martin;Penny Roon;Tracy K. Van Ells;Vadivel Ganapathy

  • CLONING AND FUNCTIONAL CHARACTERIZATION OF A POTENTIAL-SENSITIVE, POLYSPECIFIC ORGANIC CATION TRANSPORTER (OCT3) MOST ABUNDANTLY EXPRESSED IN PLACENTA

    Ramesh Kekuda;Puttur D. Prasad;Xiang Wu;Haiping Wang

  • Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1).

    Ramesh Kekuda;Puttur D. Prasad;You Jun Fei;Frederick H. Leibach

  • Amino Acid Transporters in Cancer and Their Relevance to “Glutamine Addiction”: Novel Targets for the Design of a New Class of Anticancer Drugs

    Yangzom D. Bhutia;Ellappan Babu;Sabarish Ramachandran;Vadivel Ganapathy

  • Identity of the Organic Cation Transporter OCT3 as the Extraneuronal Monoamine Transporter (uptake2) and Evidence for the Expression of the Transporter in the Brain

    Xiang Wu;Ramesh Kekuda;Wei Huang;You Jun Fei

  • Peptide Transporters in the Intestine and the Kidney

    Frederick H. Leibach;Vadivel Ganapathy

  • cDNA Sequence, Transport Function, and Genomic Organization of Human OCTN2, a New Member of the Organic Cation Transporter Family

    Xiang Wu;Puttur D. Prasad;Frederick H. Leibach;Vadivel Ganapathy

  • Functional Characteristics and Tissue Distribution Pattern of Organic Cation Transporter 2 (OCTN2), an Organic Cation/Carnitine Transporter

    Xiang Wu;Wei Huang;Puttur D. Prasad;Pankaj Seth

  • Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2.

    Mitsuru Sugawara;Wei Huang;You‐Jun Fei;Frederick H. Leibach

  • Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2

    Malliga E. Ganapathy;Wei Huang;Hong Wang;Vadivel Ganapathy

  • Cloning and Functional Characterization of a σ Receptor from Rat Brain

    Pankaj Seth;You‐Jun Fei;Hui W. Li;Wei Huang

  • Differential Recognition of β-Lactam Antibiotics by Intestinal and Renal Peptide Transporters, PEPT 1 and PEPT 2

    Malliga E. Ganapathy;Matthias Brandsch;Puttur D. Prasad;Vadivel Ganapathy

  • Functional Identification of SLC5A8, a Tumor Suppressor Down-regulated in Colon Cancer, as a Na+-coupled Transporter for Short-chain Fatty Acids

    Seiji Miyauchi;Elangovan Gopal;You-Jun Fei;Vadivel Ganapathy

Frequent Co-Authors

Puttur D. Prasad
Puttur D. Prasad Augusta University
Sylvia B. Smith
Sylvia B. Smith Augusta University
Frederick H. Leibach
Frederick H. Leibach Augusta University
Muthusamy Thangaraju
Muthusamy Thangaraju Augusta University
Virendra B. Mahesh
Virendra B. Mahesh Augusta University
Kebin Liu
Kebin Liu Augusta University
Takuya Fujita
Takuya Fujita Ritsumeikan University
Eric P. Zorrilla
Eric P. Zorrilla Scripps Research Institute
Pankaj Seth
Pankaj Seth National Brain Research Centre
Jin Sun
Jin Sun Shenyang Pharmaceutical University

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