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Muthusamy Thangaraju

Muthusamy Thangaraju

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
12346
World Ranking
16027
National Ranking
6652

Overview

Muthusamy Thangaraju is affiliated with Augusta University in the United States. Their research spans several interconnected fields primarily focusing on biochemistry, genetics, molecular biology, and medicine. They have contributed to 41 publications in the broad category of Biochemistry, Genetics and Molecular Biology, with additional work in Medicine documented across 30 publications.

The subfields of their research emphasize molecular biology with 23 publications, immunology with 12, cancer research and physiology each with 7 publications, and biochemistry with 5. Their work covers key topics including diet and metabolism studies, amino acid enzymes and metabolism, natural product bioactivities and synthesis, and digestive system and related health. Other areas of interest include immune cell function and interaction, epigenetics and DNA methylation, and Wnt/β-catenin signaling in development and cancer.

Frequent publication venues highlight a focus on both cancer and immunology research. Thangaraju has published extensively in Cancer Research (6 publications) and The Journal of Immunology (4 publications). Other notable journals where their work appears include Biochemical Journal (2 publications), Antioxidants (2 publications), and Cancers (2 publications).

Notable recent papers include:

  • Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages, 2021, Frontiers in Immunology
  • SLC6A14, a Na+/Cl−-coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling, 2020, Biochemical Journal
  • Ursolic Acid Analogs as Potential Therapeutics for Cancer, 2022, Molecules
  • Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer, 2020, Asian Journal of Pharmaceutical Sciences
  • Selenomethionine (Se-Met) Induces the Cystine/Glutamate Exchanger SLC7A11 in Cultured Human Retinal Pigment Epithelial (RPE) Cells: Implications for Antioxidant Therapy in Aging Retina, 2020, Antioxidants

Frequent coauthors collaborating on research projects with Thangaraju include:

  • Puttur D. Prasad
  • Vadivel Ganapathy
  • Santhakumar Manicassamy
  • Bal L. Lokeshwar
  • Sathish Sivaprakasam

Best Publications

  • Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

    Nagendra Singh;Ashish Gurav;Sathish Sivaprakasam;Evan Brady

  • Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

    Vadivel Ganapathy;Muthusamy Thangaraju;Puttur D. Prasad

  • GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon

    Muthusamy Thangaraju;Gail A. Cresci;Kebin Liu;Sudha Ananth

  • Solubilization of zinc compounds by the diazotrophic, plant growth promoting bacterium Gluconacetobacter diazotrophicus

    V.S. Saravanan;M. Madhaiyan;M. Thangaraju

  • Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

    Maria Ouzounova;Eunmi Lee;Raziye Piranlioglu;Abdeljabar El Andaloussi

  • Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.

    Ujendra Kumar;Ramakrishnan Sasi;Sundar Suresh;Amit Patel

  • Butyrate suppresses colonic inflammation through HDAC1-dependent Fas Upregulation and Fas-mediated apoptosis of T cells

    Mary A. Zimmerman;Nagendra Singh;Pamela Moore Martin;Muthusamy Thangaraju

  • Blockade of Dendritic Cell Development by Bacterial Fermentation Products Butyrate and Propionate through a Transporter (Slc5a8)-dependent Inhibition of Histone Deacetylases

    Nagendra Singh;Muthusamy Thangaraju;Puttur D. Prasad;Pamela M. Martin

  • Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host

    Vadivel Ganapathy;Muthusamy Thangaraju;Puttur D Prasad;Pamela M Martin

  • Sodium-coupled Monocarboxylate Transporters in Normal Tissues and in Cancer

    Vadivel Ganapathy;Muthusamy Thangaraju;Elangovan Gopal;Pamela M. Martin

  • DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

    Rajneesh Pathania;Sabarish Ramachandran;Selvakumar Elangovan;Ravi Padia

  • SLC6A14 (ATB0,+) Protein, a Highly Concentrative and Broad Specific Amino Acid Transporter, Is a Novel and Effective Drug Target for Treatment of Estrogen Receptor-positive Breast Cancer

    Senthil Karunakaran;Sabarish Ramachandran;Veena Coothankandaswamy;Selvakumar Elangovan

  • Ecological occurrence of Gluconacetobacter diazotrophicus and nitrogen-fixing Acetobacteraceae members: their possible role in plant growth promotion.

    V. S. Saravanan;V. S. Saravanan;M. Madhaiyan;Jabez W. Osborne;M. Thangaraju

  • BRCA1 facilitates stress-induced apoptosis in breast and ovarian cancer cell lines.

    Muthusamy Thangaraju;Scott H. Kaufmann;Fergus J. Couch

  • Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis.

    Yong Li;Maoxiang Zhang;Huijun Chen;Zheng Dong

  • NF-κB Directly Regulates Fas Transcription to Modulate Fas-mediated Apoptosis and Tumor Suppression

    Feiyan Liu;Feiyan Liu;Kankana Bardhan;Dafeng Yang;Muthusamy Thangaraju

  • Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3.

    Muthusamy Thangaraju;Kristina N. Carswell;Puttur D. Prasad;Vadivel Ganapathy

  • SIRT1 Is Essential for Oncogenic Signaling by Estrogen/Estrogen Receptor α in Breast Cancer

    Selvakumar Elangovan;Sabarish Ramachandran;Narayanan Venkatesan;Sudha Ananth

  • Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis.

    Danni Liu;Giovanni Martino;Muthusamy Thangaraju;Monika Sharma

  • SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases.

    Muthusamy Thangaraju;Elangovan Gopal;Pamela M. Martin;Sudha Ananth

Frequent Co-Authors

Vadivel Ganapathy
Vadivel Ganapathy Texas Tech University Health Sciences Center
Puttur D. Prasad
Puttur D. Prasad Augusta University
Kebin Liu
Kebin Liu Augusta University
Sylvia B. Smith
Sylvia B. Smith Augusta University
Zheng Dong
Zheng Dong Augusta University
David H. Munn
David H. Munn Augusta University
Pandelakis A. Koni
Pandelakis A. Koni Elixiron Immunotherapeutics (Taiwan)
Huidong Shi
Huidong Shi Augusta University
Stefan Offermanns
Stefan Offermanns Max Planck Society
John K. Cowell
John K. Cowell Augusta University

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