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Biology and Biochemistry

D-Index
71
Citations
27159
World Ranking
6515
National Ranking
426

Overview

Koji Hase is a researcher affiliated with Keio University in Japan. Their work spans multiple domains within biomedical science, focusing primarily on medicine, biochemistry, genetics, molecular biology, immunology, and microbiology. Hase's research contributions include 82 publications in medicine, 55 in biochemistry, genetics and molecular biology, and 41 in immunology and microbiology. The scientist also explores specific subfields such as molecular biology, immunology, physiology, oncology, and surgery.

The research topics covered by Koji Hase emphasize gut microbiota and health, immune cell function and interaction, and bacterial studies, specifically on Clostridium difficile and Clostridium perfringens. Their work also includes investigations into diet and metabolism as well as T-cell and B-cell immunology. Additional areas include the interplay between diet, metabolism, and disease, alongside helicobacter pylori-related gastroenterology studies.

Notable recent publications by Koji Hase include:

  • Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice, 2020, Science
  • Partners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity, 2021, Frontiers in Immunology
  • Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon, 2021, Nature Communications
  • Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells, 2022, Cell
  • Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells, 2020, EBioMedicine

Koji Hase frequently publishes in the following venues:

  • Frontiers in Immunology
  • International Immunology
  • Cell Reports
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications

The scientist collaborates regularly with several co-authors, including:

  • Daisuke Takahashi
  • Shunsuke Kimura
  • Takahiro Yamada
  • Yun-Gi Kim
  • Yumiko Fujimura

Best Publications

  • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

    Yukihiro Furusawa;Yuuki Obata;Shinji Fukuda;Takaho A. Endo

  • Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

    Koji Atarashi;Takeshi Tanoue;Kenshiro Oshima;Wataru Suda

  • Bifidobacteria can protect from enteropathogenic infection through production of acetate

    Shinji Fukuda;Hidehiro Toh;Koji Hase;Kenshiro Oshima

  • The microbiota regulates type 2 immunity through RORγt+ T cells

    Caspar Ohnmacht;Joo Hong Park;Sascha Cording;James B. Wing

  • Gut microbiota–generated metabolites in animal health and disease

    Won Jae Lee;Koji Hase

  • Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.

    Koji Hase;Kazuya Kawano;Tomonori Nochi;Gemilson Soares Pontes

  • Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice

    Ikuo Kimura;Ikuo Kimura;Junki Miyamoto;Junki Miyamoto;Ryuji Ohue-Kitano;Ryuji Ohue-Kitano;Keita Watanabe

  • Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice

    J. Y. Yang;J. Y. Yang;Y. S. Lee;Y. Kim;S. H. Lee

  • M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex.

    Koji Hase;Shunsuke Kimura;Hiroyuki Takatsu;Masumi Ohmae

  • Cell Differentiation Is a Key Determinant of Cathelicidin LL-37/Human Cationic Antimicrobial Protein 18 Expression by Human Colon Epithelium

    Koji Hase;Lars Eckmann;John D. Leopard;Nissi Varki

  • A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity

    Asuka Terashima;Hiroshi Watarai;Sayo Inoue;Etsuko Sekine

  • Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori.

    Koji Hase;Masamoto Murakami;Mitsutoshi Iimura;Sheri P Cole

  • Four Di-O-caffeoyl Quinic Acid Derivatives from Propolis. Potent Hepatoprotective Activity in Experimental Liver Injury Models

    Purusotam Basnet;Katsumichi Matsushige;Koji Hase;Shigetoshi Kadota

  • Partners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity

    Yusuke Kinashi;Koji Hase;Koji Hase

  • Comprehensive Gene Expression Profiling of Peyer’s Patch M Cells, Villous M-Like Cells, and Intestinal Epithelial Cells

    Kazutaka Terahara;Masato Yoshida;Osamu Igarashi;Tomonori Nochi

  • The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.

    Takashi Kanaya;Koji Hase;Daisuke Takahashi;Shinji Fukuda

  • Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra.

    Mizue Ohsugi;Wenzhe Fan;Koji Hase;Quanbo Xiong

  • IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens.

    Sara M. Dann;Martina E. Spehlmann;Dustin C. Hammond;Mitsutoshi Iimura

  • Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury.

    Koshu Okubo;Miho Kurosawa;Mako Kamiya;Yasuteru Urano

  • Hepatoprotective Effect of Hovenia dulcis THUNB. on Experimental Liver Injuries Induced by Carbon Tetrachloride or D-Galactosamine : Lipopolysaccharide

    Koji Hase;Mizue Ohsugi;Quanbo Xiong;Purusotam Basnet

Frequent Co-Authors

Shigetoshi Kadota
Shigetoshi Kadota University of Toyama
Shinji Fukuda
Shinji Fukuda Kanagawa Institute of Technology
Tsuneo Namba
Tsuneo Namba University of Toyama
Jun Kunisawa
Jun Kunisawa National Institutes of Biomedical Innovation, Health and Nutrition
Osamu Ohara
Osamu Ohara Chiba University
Toshihiko Iwanaga
Toshihiko Iwanaga Hokkaido University
Kenya Honda
Kenya Honda Keio University
Masahira Hattori
Masahira Hattori Waseda University
Toshiyuki Fukada
Toshiyuki Fukada Tokushima Bunri University

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