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D-Index & Metrics

Chemistry

D-Index
102
Citations
43831
World Ranking
1143
National Ranking
454

Overview

Robert Tycko is affiliated with the National Institutes of Health in the United States. Their research spans several areas within biochemistry, genetics, molecular biology, and chemistry, with significant contributions in spectroscopy and molecular biology.

Their work includes extensive studies in advanced nuclear magnetic resonance (NMR) techniques and applications, as well as research related to Alzheimer's disease treatment and molecular understanding. Other main topics include solid-state spectroscopy and crystallography, RNA research and splicing, and supramolecular self-assembly in materials.

Robert Tycko has published in notable scientific venues, with the most frequent being the Proceedings of the National Academy of Sciences, where they have seven publications. Other regular publication venues include the Journal of Magnetic Resonance, bioRxiv (Cold Spring Harbor Laboratory), the Journal of the American Chemical Society, and Nature Communications.

Frequent collaborators include Wai-Ming Yau, C. Blake Wilson, Kent R. Thurber, Jaekyun Jeon, and Ujjayini Ghosh.

Selected recent publications by Robert Tycko demonstrate the focus and range of their research:

  • "Molecular structure of a prevalent amyloid-β fibril polymorph from Alzheimer's disease brain tissue," 2021, Proceedings of the National Academy of Sciences
  • "Molecular structure and interactions within amyloid-like fibrils formed by a low-complexity protein sequence from FUS," 2020, Nature Communications
  • "Transiently structured head domains control intermediate filament assembly," 2021, Proceedings of the National Academy of Sciences
  • "Structures of brain-derived 42-residue amyloid-β fibril polymorphs with unusual molecular conformations and intermolecular interactions," 2023, Proceedings of the National Academy of Sciences
  • "Time-resolved DEER EPR and solid-state NMR afford kinetic and structural elucidation of substrate binding to Ca 2+ -ligated calmodulin," 2022, Proceedings of the National Academy of Sciences

Best Publications

  • A structural model for Alzheimer's β-amyloid fibrils based on experimental constraints from solid state NMR

    Aneta T. Petkova;Yoshitaka Ishii;John J. Balbach;Oleg N. Antzutkin

  • Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

    Masato Kato;Tina W. Han;Shanhai Xie;Kevin Shi

  • Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid Fibrils

    Aneta T. Petkova;Richard D. Leapman;Zhihong Guo;Wai Ming Yau

  • Experimental Constraints on Quaternary Structure in Alzheimer's β-Amyloid Fibrils†

    Aneta T. Petkova;Wai-Ming Yau;Robert Tycko

  • Molecular structural basis for polymorphism in Alzheimer's β-amyloid fibrils

    Anant K. Paravastu;Richard D. Leapman;Wai-Ming Yau;Robert Tycko

  • Conducting films of C60 and C70 by alkali-metal doping

    R. C. Haddon;A. F. Hebard;M. J. Rosseinsky;D. W. Murphy

  • Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

    Jun-Xia Lu;Wei Qiang;Wai-Ming Yau;Charles D. Schwieters

  • Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains

    Dylan T. Murray;Masato Kato;Yi Lin;Kent R. Thurber

  • Amyloid Fibril Formation by Aβ16-22, a Seven-Residue Fragment of the Alzheimer's β-Amyloid Peptide, and Structural Characterization by Solid State NMR†

    John J. Balbach;Yoshitaka Ishii;Oleg N. Antzutkin;Richard D. Leapman

  • New Phases of C60 Synthesized at High Pressure

    Y. Iwasa;T. Arima;R. M. Fleming;T. Siegrist

  • Molecular structure of amyloid fibrils: insights from solid-state NMR

    Robert Tycko

  • Optically pumped NMR evidence for finite-size skyrmions in GaAs quantum wells near Landau level filling nu =1.

    S. E. Barrett;G. Dabbagh;L. N. Pfeiffer;K. W. West

  • Solid-state NMR studies of amyloid fibril structure.

    Robert Tycko

  • Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

    Wei Qiang;Wai-Ming Yau;Jun-Xia Lu;John Collinge

  • Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR.

    Sorin Luca;Wai-Ming Yau;Richard Leapman;Robert Tycko

  • Molecular dynamics and the phase transition in solid C 60

    R. Tycko;G. Dabbagh;R. M. Fleming;R. C. Haddon

  • Amyloid Polymorphism: Structural Basis and Neurobiological Relevance

    Robert Tycko

  • Progress towards a molecular-level structural understanding of amyloid fibrils.

    Robert Tycko

  • Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of β-sheets in Alzheimer's β-amyloid fibrils

    Oleg N. Antzutkin;John J. Balbach;Richard D. Leapman;Nancy W. Rizzo

  • Alignment of Biopolymers in Strained Gels: A New Way To Create Detectable Dipole−Dipole Couplings in High-Resolution Biomolecular NMR

    Robert Tycko;and Francisco J. Blanco;Yoshitaka Ishii

Frequent Co-Authors

Donald W. Murphy
Donald W. Murphy Alcatel Lucent (Germany)
Matthew J. Rosseinsky
Matthew J. Rosseinsky University of Liverpool
R. M. Fleming
R. M. Fleming Sandia National Laboratories
Reed B. Wickner
Reed B. Wickner National Institutes of Health
Robert C. Haddon
Robert C. Haddon University of California, Riverside
Stephen C. Meredith
Stephen C. Meredith University of Chicago
Theo Siegrist
Theo Siegrist Florida A&M University - Florida State University College of Engineering
Arthur P. Ramirez
Arthur P. Ramirez University of California, Santa Cruz
John C. Tully
John C. Tully Yale University
Steven L. McKnight
Steven L. McKnight The University of Texas Southwestern Medical Center

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