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Stephen C. Meredith

Stephen C. Meredith

D-Index & Metrics

Chemistry

D-Index
45
Citations
11732
World Ranking
16253
National Ranking
4053

Biology and Biochemistry

D-Index
52
Citations
13359
World Ranking
16506
National Ranking
6833

Overview

Stephen C. Meredith is affiliated with the University of Chicago in the United States. Their research spans multiple fields within medicine and biochemistry, genetics, and molecular biology, with a particular focus on Alzheimer's disease, molecular biology, physiology, and oncology.

The scientist has contributed notably to the study of Alzheimer's disease research and treatments, as well as supramolecular self-assembly in materials. Their work also addresses advanced nuclear magnetic resonance (NMR) techniques and applications, drug transport and resistance mechanisms, and the role of microRNA and circular RNAs in disease regulation. Cancer-related molecular mechanisms are another area covered in their research.

Recent publications by Stephen C. Meredith include:

  • "Sensitivity-Enhanced Solid-State NMR Detection of Structural Differences and Unique Polymorphs in Pico- to Nanomolar Amounts of Brain-Derived and Synthetic 42-Residue Amyloid-β Fibrils" (2021) published in the Journal of the American Chemical Society
  • "Upregulation of polycistronic microRNA-143 and microRNA-145 in colonocytes suppresses colitis and inflammation-associated colon cancer" (2020) in Epigenetics
  • "Atomic-level differences between brain parenchymal- and cerebrovascular-seeded Aβ fibrils" (2021) in Scientific Reports
  • "Serine 408 phosphorylation is a molecular switch that regulates structure and function of the occludin α-helical bundle" (2022) in Proceedings of the National Academy of Sciences
  • "Nanodroplet Oligomers (NanDOs) of Aβ40" (2021) in Biochemistry

Frequent coauthors collaborating with Stephen C. Meredith include Joseph R. Sachleben, Atul Srivastava, Bharat Somireddy Venkata, Patrick C. Moore, and Esmael J. Haddadian. These collaborations highlight consistent teamwork across several research projects.

Publication venues where Meredith's work frequently appears are:

  • Biophysical Journal
  • Journal of the American Chemical Society
  • Epigenetics
  • Scientific Reports
  • Proceedings of the National Academy of Sciences

Main fields of study encompass medicine and biochemistry, genetics, and molecular biology. Subfields represented in their publications include physiology, molecular biology, oncology, spectroscopy, and biomaterials.

The scope of their research topics include:

  • Alzheimer's disease research and treatments
  • Supramolecular self-assembly in materials
  • Advanced NMR techniques and applications
  • Drug transport and resistance mechanisms
  • MicroRNA in disease regulation
  • Circular RNAs in diseases
  • Cancer-related molecular mechanisms research

Best Publications

  • Amino acid analysis by reverse-phase high-performance liquid chromatography: precolumn derivatization with phenylisothiocyanate.

    Robert L. Heinrikson;Stephen C. Meredith

  • Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

    Jun-Xia Lu;Wei Qiang;Wai-Ming Yau;Charles D. Schwieters

  • Propagating structure of Alzheimer’s β-amyloid(10–35) is parallel β-sheet with residues in exact register

    Tammie L. S. Benzinger;David M. Gregory;Timothy S. Burkoth;Hélène Miller-Auer

  • Supramolecular Structure in Full-Length Alzheimer's β-Amyloid Fibrils: Evidence for a Parallel β-Sheet Organization from Solid-State Nuclear Magnetic Resonance

    John J. Balbach;Aneta T. Petkova;Nathan A. Oyler;Oleg N. Antzutkin

  • Seeded growth of β-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

    Anant K. Paravastu;Isam Qahwash;Richard D. Leapman;Stephen C. Meredith

  • Molecular Structure of beta-Amyloid Fibrils in Alzheimer's Disease Brain Tissue.

    Jun-Xia Lu;Wei Qiang;Wai-Ming Yau;Charles D. Schwieters

  • Inhibition of beta-amyloid(40) fibrillogenesis and disassembly of beta-amyloid(40) fibrils by short beta-amyloid congeners containing N-methyl amino acids at alternate residues.

    David J. Gordon;Kimberly L. Sciarretta;Stephen C. Meredith

  • A unique tumor antigen produced by a single amino acid substitution.

    Paul A. Monach;Stephen C. Meredith;Christopher T.Siegel;Hans Schreiber

  • Abeta40-Lactam(D23/K28) models a conformation highly favorable for nucleation of amyloid.

    Kimberly L Sciarretta;David J Gordon;Aneta T Petkova;Robert Tycko

  • Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells.

    Michael T. Spiotto;Ping Yu;Donald A. Rowley;Michael I. Nishimura

  • Vitamin D deficiency and bone disease in patients with Crohn's disease

    R.H. Driscoll;S.C. Meredith;M. Sitrin;I.H. Rosenberg

  • Two-Dimensional Structure of β-Amyloid(10−35) Fibrils†

    Tammie L. S. Benzinger;David M. Gregory;Timothy S. Burkoth;Hélène Miller-Auer

  • Design and characterization of a membrane permeable N‐methyl amino acid‐containing peptide that inhibits Aβ1–40 fibrillogenesis

    D.J. Gordon;R. Tappe;S.C. Meredith

  • Relapse or Eradication of Cancer Is Predicted by Peptide-Major Histocompatibility Complex Affinity

    Boris Engels;Victor H. Engelhard;John Sidney;Alessandro Sette

  • Flanking Polyproline Sequences Inhibit β-Sheet Structure in Polyglutamine Segments by Inducing PPII-like Helix Structure

    Gregory Darnell;Joseph P.R.O. Orgel;Joseph P.R.O. Orgel;Reinhard Pahl;Stephen C. Meredith

  • A Mutant Chaperone Converts a Wild-Type Protein into a Tumor-Specific Antigen

    Andrea Schietinger;Mary Philip;Barbara A. Yoshida;Parastoo Azadi

  • Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia

    Seong Hun Kim;Rong Wang;David J. Gordon;Joseph Bass

  • Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide.

    L K Shawver;D P Schwartz;E Mann;H Chen

  • Peptide-based inhibitors of amyloid assembly.

    Kimberly L Sciarretta;David J Gordon;Stephen C Meredith

  • Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal

    Margaret G. Distler;Leigh D. Plant;Greta Sokoloff;Andrew J. Hawk

  • Protein denaturation and aggregation: Cellular responses to denatured and aggregated proteins.

    Stephen C. Meredith

Frequent Co-Authors

David G. Lynn
David G. Lynn Emory University
David J. Gordon
David J. Gordon University of Iowa
Robert Tycko
Robert Tycko National Institutes of Health
Hans Schreiber
Hans Schreiber University of Chicago
Irwin H. Rosenberg
Irwin H. Rosenberg Tufts University
Tammie L.S. Benzinger
Tammie L.S. Benzinger Washington University in St. Louis
Tobin R. Sosnick
Tobin R. Sosnick University of Chicago
Sangram S. Sisodia
Sangram S. Sisodia University of Chicago
Godfrey S. Getz
Godfrey S. Getz University of Chicago
Karl F. Freed
Karl F. Freed University of Chicago

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