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Genetics

D-Index
92
Citations
24077
World Ranking
1014
National Ranking
494

Research.com Recognitions

  • 2000 - Member of the National Academy of Sciences
  • 1998 - Fellow of the American Academy of Arts and Sciences

Overview

Reed B. Wickner is affiliated with the National Institutes of Health in the United States. Their research contributions primarily focus on prion diseases and protein misfolding, with significant work in biochemistry, genetics, molecular biology, neuroscience, and nursing. The main subfields of their study include molecular biology, neurology, nutrition and dietetics, cell biology, and materials chemistry.

The scientist's research extensively covers topics such as:

  • Prion Diseases and Protein Misfolding
  • Neurological diseases and metabolism
  • Trace Elements in Health
  • Endoplasmic Reticulum Stress and Disease
  • Enzyme Structure and Function
  • Plant and Fungal Interactions Research
  • Fungal and yeast genetics research

Frequent collaborators in their publications include Herman K. Edskes, Moonil Son, Songsong Wu, Madaleine Niznikiewicz, and Evgeny E. Bezsonov.

Their work has been published predominantly in the following venues:

  • Proceedings of the National Academy of Sciences
  • Genetics
  • Current Genetics
  • PLoS Pathogens
  • International Journal of Molecular Sciences

Recent publications authored or co-authored by Reed B. Wickner include:

  • "Normal levels of ribosome-associated chaperones cure two groups of [PSI+] prion variants" (2020), Proceedings of the National Academy of Sciences
  • "Innate immunity to prions: anti-prion systems turn a tsunami of prions into a slow drip" (2021), Current Genetics
  • "Antiprion systems in yeast cooperate to cure or prevent the generation of nearly all [ PSI + ] and [URE3] prions" (2022), Proceedings of the National Academy of Sciences
  • "How Do Yeast Cells Contend with Prions?" (2020), International Journal of Molecular Sciences
  • "Prions are the greatest protein misfolding problem, and yeast has several solutions" (2023), PLoS Pathogens

The scientist has been recognized through membership and fellowship in notable organizations:

  • Member of the National Academy of Sciences (2000)
  • Fellow of the American Academy of Arts and Sciences (1998)

Best Publications

  • [URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae.

    Reed B. Wickner

  • Prion-inducing domain of yeast Ure2p and protease resistance of Ure2p in prion-containing cells.

    Daniel C. Masison;Reed B. Wickner

  • A -1 ribosomal frameshift in a double-stranded RNA virus of yeast forms a gag-pol fusion protein.

    Jonathan D. Dinman;Tateo Icho;Reed B. Wickner

  • [URE3] Prion Propagation in Saccharomyces cerevisiae: Requirement for Chaperone Hsp104 and Curing by Overexpressed Chaperone Ydj1p

    Hiromitsu Moriyama;Herman K. Edskes;Reed B. Wickner

  • Molecular Structures of Amyloid and Prion Fibrils: Consensus versus Controversy

    Robert Tycko;Reed B. Wickner

  • Double-stranded RNA viruses of Saccharomyces cerevisiae.

    Reed B. Wickner

  • The double-stranded RNA genome of yeast virus L-A encodes its own putative RNA polymerase by fusing two open reading frames.

    T Icho;R B Wickner

  • Amyloid of the prion domain of Sup35p has an in-register parallel β-sheet structure

    Frank Shewmaker;Reed B. Wickner;Robert Tycko

  • Prion Domain Initiation of Amyloid Formation in Vitro from Native Ure2p

    Kimberly L. Taylor;Naiqian Cheng;Robert W. Williams;Alasdair C. Steven

  • Interactions among prions and prion “strains” in yeast

    Michael E. Bradley;Herman K. Edskes;Joo Y. Hong;Reed B. Wickner

  • Ribosomal frameshifting efficiency and gag/gag-pol ratio are critical for yeast M1 double-stranded RNA virus propagation.

    J D Dinman;R B Wickner

  • Prions of fungi: inherited structures and biological roles

    Reed B. Wickner;Herman K. Edskes;Frank Shewmaker;Toru Nakayashiki

  • Yeast prions [URE3] and [PSI+] are diseases

    Toru Nakayashiki;Cletus P. Kurtzman;Herman K. Edskes;Reed B. Wickner

  • The [URE3] prion is an aggregated form of Ure2p that can be cured by overexpression of Ure2p fragments

    Herman K. Edskes;Vaughn T. Gray;Reed B. Wickner

  • Prion generation in vitro: amyloid of Ure2p is infectious

    Andreas Brachmann;Ulrich Baxa;Reed Brendon Wickner

  • Suicidal [PSI+] is a lethal yeast prion.

    Ryan P. McGlinchey;Dmitry Kryndushkin;Reed B. Wickner

  • Primary sequence independence for prion formation

    Eric D. Ross;Herman K. Edskes;Michael J. Terry;Reed B. Wickner

  • L-A virus at 3.4 Å resolution reveals particle architecture and mRNA decapping mechanism

    Hisashi Naitow;Jinghua Tang;Mary Canady;Reed B. Wickner

  • The prion model for [URE3] of yeast: Spontaneous generation and requirements for propagation

    Daniel C. Masison;Marie-Lise Maddelein;Reed B. Wickner

  • Ribosomal Frameshifting Efficiency andgag/gag-pol RatioAre Critical forYeastM1Double-Stranded RNA VirusPropagation

    Jonathan D. Dinman;Reed B. Wickner

Frequent Co-Authors

Ulrich Baxa
Ulrich Baxa Leidos (United States)
Robert Tycko
Robert Tycko National Institutes of Health
Alasdair C. Steven
Alasdair C. Steven National Institutes of Health
Jonathan D. Dinman
Jonathan D. Dinman University of Maryland, College Park
Herbert Tabor
Herbert Tabor National Institutes of Health
Naiqian Cheng
Naiqian Cheng National Institutes of Health
John E. Johnson
John E. Johnson Scripps Research Institute
Fred Dyda
Fred Dyda National Institutes of Health
Steven G. Ball
Steven G. Ball University of Lille
Kathleen M. Carroll
Kathleen M. Carroll Yale University

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