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Genetics

D-Index
54
Citations
10348
World Ranking
3652
National Ranking
1584

Overview

Susan W. Liebman is affiliated with the University of Nevada Reno in the United States. Their research primarily focuses on the intersection of medicine and biochemistry, genetics, and molecular biology, with specific attention to neurology-related topics.

Their scholarly output includes several papers published between 2020 and 2024, addressing molecular mechanisms involved in neurodegenerative diseases and protein toxicity. Notable publications include:

  • Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy (2021, RNA Biology)
  • Tumor suppressor protein p53 expressed in yeast can remain diffuse, form a prion, or form unstable liquid-like droplets (2020, iScience)
  • TDP-43 Toxicity in Yeast Is Associated with a Reduction in Autophagy, and Deletions of TIP41 and PBP1 Counteract These Effects (2022, Viruses)
  • Expression of Wild-Type and Mutant Human TDP-43 in Yeast Inhibits TOROID (TORC1 Organized in Inhibited Domain) Formation and Autophagy Proportionally to the Levels of TDP-43 Toxicity (2024, International Journal of Molecular Sciences)
  • A model of inborn metabolism errors associated with adenine amyloid-like fiber formation reduces TDP-43 aggregation and toxicity in yeast (2024, bioRxiv (Cold Spring Harbor Laboratory))

The research prominently explores topics such as amyotrophic lateral sclerosis, neurological diseases with metabolic components, prion diseases and protein misfolding, as well as RNA research and splicing. Additional thematic concentrations include mechanisms and treatments of Parkinson's disease and cancer-related gene regulation and molecular pathways.

Frequent coauthors in their work include:

  • Sangeun Park
  • Sei-Kyoung Park
  • Irina L. Derkatch
  • Koji Matsukawa
  • Michail S. Kukharsky

Susan W. Liebman has published regularly in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Viruses
  • RNA Biology
  • iScience
  • International Journal of Molecular Sciences

Their subfields of study encompass neurology, molecular biology, cardiology and cardiovascular medicine, cellular and molecular neuroscience, and oncology. The combination of these areas illustrates a multidisciplinary approach centered on understanding molecular mechanisms underlying neurological and cellular dysfunction associated with disease processes.

Best Publications

  • Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+].

    Yury O. Chernoff;Susan L. Lindquist;Bun-ichiro Ono;Sergei G. Inge-Vechtomov

  • Prions Affect the Appearance of Other Prions: The Story of [PIN+]

    Irina L Derkatch;Michael E Bradley;Joo Y Hong;Susan W Liebman

  • Genesis and Variability of [ PSI ] Prion Factors in Saccharomyces cerevisiae

    Irina L. Derkatch;Irina L. Derkatch;Yury O. Chernoff;Yury O. Chernoff;Yury O. Chernoff;Vitaly V. Kushnirov;Sergey G. Inge-Vechtomov

  • Genetic and Environmental Factors Affecting the de novo Appearance of the [PSI + ] Prion in Saccharomyces cerevisiae

    Irina L. Derkatch;Michael E. Bradley;Ping Zhou;Yury O. Chernoff

  • Prions in Yeast

    Susan W. Liebman;Yury O. Chernoff

  • The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion

    Basant K Patel;Jackie Gavin-Smyth;Jackie Gavin-Smyth;Susan W Liebman

  • Interactions among prions and prion “strains” in yeast

    Michael E. Bradley;Herman K. Edskes;Joo Y. Hong;Reed B. Wickner

  • Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro.

    Irina L. Derkatch;Susan M. Uptain;Tiago F. Outeiro;Rajaraman Krishnan

  • Dependence and independence of [PSI+] and [PIN+]: a two-prion system in yeast?

    Irina L. Derkatch;Michael E. Bradley;Sherie V.L. Masse;Sergei P. Zadorsky

  • Analysis of Amyloid Aggregates Using Agarose Gel Electrophoresis

    Sviatoslav N. Bagriantsev;Vitaly V. Kushnirov;Susan W. Liebman

  • The ubiquitin-conjugating enzyme Rad6 (Ubc2) is required for silencing in Saccharomyces cerevisiae.

    Hanhua Huang;Alon Kahana;Daniel E. Gottschling;Louise Prakash

  • The relationship between visible intracellular aggregates that appear after overexpression of Sup35 and the yeast prion‐like elements [PSI+] and [PIN+]

    Ping Zhou;Irina L. Derkatch;Susan W. Liebman;Susan W. Liebman

  • Mutations in eukaryotic 18S ribosomal RNA affect translational fidelity and resistance to aminoglycoside antibiotics.

    Y.O. Chernoff;A. Vincent;S.W. Liebman

  • "Prion-proof" for [PIN+]: infection with in vitro-made amyloid aggregates of Rnq1p-(132-405) induces [PIN+].

    Basant K Patel;Susan W Liebman

  • Variant-specific [PSI+] infection is transmitted by Sup35 polymers within [PSI+] aggregates with heterogeneous protein composition.

    Sviatoslav N. Bagriantsev;Elena O. Gracheva;Janet E. Richmond;Susan W. Liebman

  • An accuracy center in the ribosome conserved over 2 billion years.

    Lefa E. Alksne;Richard A. Anthony;Susan W. Liebman;Jonathan R. Warner

  • The yeast non‐Mendelian factor [ETA+] is a variant of [PSI+], a prion‐like form of release factor eRF3

    Ping Zhou;Irina L. Derkatch;Susan M. Uptain;Maria M. Patino

  • Extrachromosomal psi+ determinant suppresses nonsense mutations in yeast.

    S W Liebman;F Sherman

  • Destabilizing Interactions Among [PSI +] and [PIN +] Yeast Prion Variants

    Michael E. Bradley;Susan W. Liebman

  • Modulation of Aβ 42 low-n oligomerization using a novel yeast reporter system

    Sviatoslav Bagriantsev;Susan Liebman

Frequent Co-Authors

Yury O. Chernoff
Yury O. Chernoff Georgia Institute of Technology
Andrew D. Mesecar
Andrew D. Mesecar Purdue University West Lafayette
Takeshi Iwatsubo
Takeshi Iwatsubo University of Tokyo
Alexander S. Mankin
Alexander S. Mankin University of Illinois at Chicago
Jonathan R. Warner
Jonathan R. Warner Albert Einstein College of Medicine
Reed B. Wickner
Reed B. Wickner National Institutes of Health
Judith Berman
Judith Berman Tel Aviv University
Fred Sherman
Fred Sherman University of Rochester
James E. Haber
James E. Haber Brandeis University

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