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D-Index
75
Citations
14998
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1912
National Ranking
874

Overview

Alexander S. Mankin is affiliated with the University of Illinois at Chicago in the United States. The primary focus of their research lies within the broad field of Biochemistry, Genetics and Molecular Biology, with a significant concentration on Molecular Biology. Their work spans several interconnected subfields including Genetics, Microbiology, Infectious Diseases, and Ecology.

The scientist has contributed extensively to topics related to RNA and protein synthesis mechanisms, RNA modifications and cancer, and bacterial genetics and biotechnology. Other areas of focus include antimicrobial peptides and activities, bacteriophages and microbial interactions, as well as genomics and phylogenetic studies. Their research also involves biochemical and structural characterization.

Frequent coauthors who have collaborated with Alexander S. Mankin include Nora Vázquez-Laslop, Dorota Klepacki, Yury S. Polikanov, Chetana Baliga, and Elena V. Aleksandrova.

Mankin's research outputs have been published regularly in numerous scientific venues. Key journals and platforms for their publications include:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Nature Chemical Biology
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature

Some of their recent papers are:

  • A synthetic antibiotic class overcoming bacterial multidrug resistance, 2021, Nature
  • Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance, 2021, Nature Chemical Biology
  • Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics, 2021, Nature Communications
  • Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics, 2022, Nature Structural & Molecular Biology
  • Identifying Small Open Reading Frames in Prokaryotes with Ribosome Profiling, 2021, Journal of Bacteriology

Best Publications

  • Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.

    Jack A. Dunkle;Liqun Xiong;Alexander S. Mankin;Jamie H. D. Cate

  • Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid

    Seok Ming Toh;Liqun Xiong;Cesar A. Arias;Cesar A. Arias;Maria V. Villegas

  • Macrolide Antibiotics: Binding Site, Mechanism of Action, Resistance

    Marne Gaynor;Alexander S. Mankin

  • The Site of Action of Oxazolidinone Antibiotics in Living Bacteria and in Human Mitochondria

    Karen L. Leach;Steven M. Swaney;Jerry R. Colca;William G. McDonald

  • How Macrolide Antibiotics Work

    Nora Vázquez-Laslop;Alexander S. Mankin

  • Molecular Mechanism of Drug-Dependent Ribosome Stalling

    Nora Vazquez-Laslop;Celine Thum;Alexander S. Mankin

  • Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center.

    Patricia Kloss;Liqun Xiong;Dean L Shinabarger;Alexander S Mankin

  • Nucleotide Biosynthesis Is Critical for Growth of Bacteria in Human Blood

    Shalaka Samant;Hyunwoo Lee;Mahmood Ghassemi;Juan Chen

  • Protein synthesis by ribosomes with tethered subunits

    Cédric Orelle;Erik D. Carlson;Teresa Szal;Tanja Florin

  • The Ribosomal Peptidyl Transferase Center: Structure, Function, Evolution, Inhibition

    Norbert Polacek;Alexander S Mankin

  • Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action

    Liqun Xiong;Patricia Kloss;Stephen Douthwaite;Niels Møller Andersen

  • Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide

    Norbert Polacek;Marne Gaynor;Aymen Yassin;Alexander S. Mankin

  • Antibiotics and the ribosome

    Tanel Tenson;Alexander Mankin

  • A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre

    Liqun Xiong;Sunita Shah;Pascale Mauvais;Alexander S. Mankin

  • The general mode of translation inhibition by macrolide antibiotics

    Krishna Kannan;Pinal Kanabar;David Schryer;Tanja Florin

  • Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics

    Jerry R. Colca;William G. McDonald;Daniel J. Waldon;Lisa M. Thomasco

  • Programmed drug-dependent ribosome stalling.

    Haripriya Ramu;Alexander Mankin;Nora Vazquez-Laslop

  • RlmN and Cfr are Radical SAM Enzymes Involved in Methylation of Ribosomal RNA

    Feng Yan;Jacqueline M. LaMarre;Rene Röhrich;Jochen Wiesner

  • Binding Site of Macrolide Antibiotics on the Ribosome: New Resistance Mutation Identifies a Specific Interaction of Ketolides with rRNA

    Georgina Garza-Ramos;Liqun Xiong;Ping Zhong;Alexander Mankin

  • The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide

    Nora Vázquez‐Laslop;Haripriya Ramu;Dorota Klepacki;Krishna Kannan

Frequent Co-Authors

Tanel Tenson
Tanel Tenson University of Tartu
Roger A. Garrett
Roger A. Garrett University of Copenhagen
Michael C. Jewett
Michael C. Jewett Northwestern University
Philipp Khaitovich
Philipp Khaitovich Skolkovo Institute of Science and Technology
Harry F. Noller
Harry F. Noller University of California, Santa Cruz
Thomas A. Steitz
Thomas A. Steitz Yale University
Daniel N. Wilson
Daniel N. Wilson Universität Hamburg
Marina V. Rodnina
Marina V. Rodnina Max Planck Society
Rachel Green
Rachel Green Johns Hopkins University School of Medicine
Erik C. Böttger
Erik C. Böttger University of Zurich

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