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Molecular Biology

D-Index
112
Citations
49917
World Ranking
340
National Ranking
201

Research.com Recognitions

  • 2017 - Breakthrough Prize in Life Sciences for discovering the centrality of RNA in forming the active centers of the ribosome, the fundamental machinery of protein synthesis in all cells, thereby connecting modern biology to the origin of life and also explaining how many natural antibiotics disrupt protein synthesis.
  • 2012 - Gregori Aminoff Prize, Royal Swedish Academy of Sciences for their crystallographic studies on ribosomes, translators of the code of life
  • 2007 - Paul Ehrlich and Ludwig Darmstaedter Prize
  • 2007 - Canada Gairdner International Award
  • 1999 - Fellow of the American Academy of Arts and Sciences
  • 1992 - Member of the National Academy of Sciences

Overview

Harry F. Noller is affiliated with the University of California, Santa Cruz in the United States. Their research primarily falls under the field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Genetics, Plant Science, and Epidemiology as subfields.

Their work extensively covers topics such as RNA and protein synthesis mechanisms, RNA modifications and cancer, bacterial genetics and biotechnology, RNA research and splicing, genomics and phylogenetic studies, plant virus research studies, and influenza virus research studies.

Recent publications by Noller include the following papers: The ribosome comes to life (2024, Cell), The universally conserved nucleotides of the small subunit ribosomal RNAs (2022, RNA), The structural basis for inhibition of ribosomal translocation by viomycin (2020, Proceedings of the National Academy of Sciences), and others involving co-authors.

Frequent co-authors collaborating with Noller are Laura Lancaster, John P. Donohue, Gillian Rexroad, Dustin Niblett, and Robin R. Gutell.

Key venues publishing their research include RNA, Proceedings of the National Academy of Sciences, Cell, Nucleic Acids Research, and Nature Communications.

Awards received by Harry F. Noller include the Breakthrough Prize in Life Sciences (2017) for research on RNA's central role in ribosomal function, the Gregori Aminoff Prize from the Royal Swedish Academy of Sciences (2012) for crystallographic studies on ribosomes, the Paul Ehrlich and Ludwig Darmstaedter Prize (2007), the Canada Gairdner International Award (2007), fellowship of the American Academy of Arts and Sciences (1999), and membership in the National Academy of Sciences (1992).

  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • Bacterial Genetics and Biotechnology
  • RNA Research and Splicing
  • Genomics and Phylogenetic Studies
  • Plant Virus Research Studies
  • Influenza Virus Research Studies

  • Laura Lancaster
  • John P. Donohue
  • Gillian Rexroad
  • Dustin Niblett
  • Robin R. Gutell

  • RNA
  • Proceedings of the National Academy of Sciences
  • Cell
  • Nucleic Acids Research
  • Nature Communications

  • The ribosome comes to life (2024, Cell)
  • The universally conserved nucleotides of the small subunit ribosomal RNAs (2022, RNA)
  • The structural basis for inhibition of ribosomal translocation by viomycin (2020, Proceedings of the National Academy of Sciences)
  • Mutations in domain IV of elongation factor EF-G confer −1 frameshifting (2020, RNA)
  • The role of GTP hydrolysis by EF-G in ribosomal translocation (2022, Proceedings of the National Academy of Sciences)

Best Publications

  • Complete nucleotide sequence of a 16S ribosomal RNA gene from Escherichia coli.

    Jurgen Brosius;Margaret L. Palmer;Poindexter J. Kennedy;Harry F. Noller

  • Gene organization and primary structure of a ribosomal RNA operon from Escherichia coli

    Jürgen Brosius;Thomas J. Dull;Donald D. Sleeter;Harry F. Noller

  • Crystal structure of the ribosome at 5.5 A resolution

    Marat M. Yusupov;Gulnara Zh. Yusupova;Albion Baucom;Kate Lieberman

  • Interaction of antibiotics with functional sites in 16S ribosomal RNA

    Danesh Moazed;Harry F. Noller

  • STRUCTURE OF RIBOSOMAL RNA

    Harry F. Noller

  • Unusual resistance of peptidyl transferase to protein extraction procedures

    Harry F. Noller;Vernita Hoffarth;Ludwika Zimniak

  • Intermediate states in the movement of transfer RNA in the ribosome

    Danesh Moazed;Harry F. Noller

  • Detailed analysis of the higher-order structure of 16S-like ribosomal ribonucleic acids.

    C. R. Woese;R. Gutell;Ramesh Gupta;H. F. Noller

  • Comparative Anatomy of 16-S-like Ribosomal RNA

    Robin R. Gutell;Bryn Weiser;Carl R. Woese;Harry F. Noller

  • X-ray Crystal Structures of 70S Ribosome Functional Complexes

    Jamie H. Cate;Marat M. Yusupov;Gulnara Zh. Yusupova;Thomas N. Earnest

  • RIBOSOMES AND TRANSLATION

    Rachel Green;Harry F. Noller

  • The Path of Messenger RNA through the Ribosome

    Gulnara Zh. Yusupova;Marat M. Yusupov;J.H.D. Cate;Harry F. Noller

  • mRNA helicase activity of the ribosome

    Seyedtaghi Takyar;Robyn P. Hickerson;Harry F. Noller

  • Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements

    Andrei Korostelev;Sergei Trakhanov;Martin Laurberg;Harry F. Noller

  • Ribosomal RNA and Translation

    Harry F. Noller

  • Rapid chemical probing of conformation in 16 S ribosomal RNA and 30 S ribosomal subunits using primer extension

    Danesh Moazed;Seth Stern;Harry F. Noller

  • Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites

    Danesh Moazed;Harry F. Noller

  • Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA

    Danesh Moazed;James M. Robertson;Harry F. Noller

  • A new system for naming ribosomal proteins

    Nenad Ban;Roland Beckmann;Jamie H D Cate;Jonathan D Dinman

  • Following translation by single ribosomes one codon at a time

    Jin-Der Wen;Laura Lancaster;Courtney Hodges;Ana-Carolina Zeri

Frequent Co-Authors

Danesh Moazed
Danesh Moazed Harvard University
Jamie H. D. Cate
Jamie H. D. Cate University of California, Berkeley
Rachel Green
Rachel Green Johns Hopkins University School of Medicine
Robin R. Gutell
Robin R. Gutell The University of Texas at Austin
Carlos Bustamante
Carlos Bustamante Stanford University
Ignacio Tinoco
Ignacio Tinoco University of California, Berkeley
Carl R. Woese
Carl R. Woese University of Illinois at Urbana-Champaign
Jürgen Brosius
Jürgen Brosius University of Münster
Taekjip Ha
Taekjip Ha Johns Hopkins University
Alexander S. Mankin
Alexander S. Mankin University of Illinois at Chicago

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