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Molecular Biology

D-Index
81
Citations
22103
World Ranking
969
National Ranking
516

Research.com Recognitions

  • 2014 - Member of the National Academy of Sciences
  • 1997 - Fellow of Alfred P. Sloan Foundation

Overview

Joseph D. Puglisi is affiliated with Stanford University in the United States. The primary focus of their research lies in the fields of biochemistry, genetics, and molecular biology, with an emphasis on molecular biology as a subfield.

Their scholarly work extensively covers topics related to RNA and protein synthesis mechanisms, RNA modifications and cancer, and RNA research and splicing. Additional areas of investigation include CRISPR and genetic engineering, viral infections and immunology research, bacteriophages and microbial interactions, as well as advanced biosensing and bioanalysis techniques.

Joseph D. Puglisi has published numerous papers in a variety of scientific journals. Notable recent publications include:

  • Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation (2021, Proceedings of the National Academy of Sciences)
  • Rapid 40S scanning and its regulation by mRNA structure during eukaryotic translation initiation (2022, Cell)
  • eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining (2022, Nature)
  • Mechanisms that ensure speed and fidelity in eukaryotic translation termination (2021, Science)
  • The energy landscape of −1 ribosomal frameshifting (2020, Science Advances)

The scientist frequently collaborates with several co-authors, including Jinfan Wang, Christopher P. Lapointe, Carlos Alvarado, Rosslyn Grosely, and Thomas Dever.

Their work is often published in prominent venues such as bioRxiv (Cold Spring Harbor Laboratory), Biophysical Journal, Nucleic Acids Research, Proceedings of the National Academy of Sciences, and Molecular Cell.

Among the awards received, Joseph D. Puglisi became a Member of the National Academy of Sciences in 2014. They were also recognized as a Fellow of the Alfred P. Sloan Foundation in 1997.

Best Publications

  • Structure of the A Site of Escherichia coli 16S Ribosomal RNA Complexed with an Aminoglycoside Antibiotic

    Dominique Fourmy;Michael I. Recht;Scott C. Blanchard;Joseph D. Puglisi

  • An Oxygen Scavenging System for Improvement of Dye Stability in Single-Molecule Fluorescence Experiments

    Colin Echeverría Aitken;R. Andrew Marshall;Joseph D. Puglisi

  • Absorbance melting curves of RNA.

    Joseph D. Puglisi;Ignacio Tinoco

  • Conformation of the TAR RNA-arginine complex by NMR spectroscopy

    Joseph D. Puglisi;Ruoying Tan;Barbara J. Calnan;Alan D. Frankel

  • tRNA dynamics on the ribosome during translation

    Scott C. Blanchard;Harold D. Kim;Ruben L. Gonzalez;Joseph D. Puglisi

  • Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

    Michael P. Bokoch;Yaozhong Zou;Søren G F Rasmussen;Corey W. Liu

  • tRNA selection and kinetic proofreading in translation.

    Scott C Blanchard;Ruben L Gonzalez;Harold D Kim;Steven Chu

  • Structural origins of gentamicin antibiotic action

    Satoko Yoshizawa;Dominique Fourmy;Joseph D. Puglisi

  • Solution Structure of a Bovine Immunodeficiency Virus Tat-TAR Peptide-RNA Complex

    Joseph D. Puglisi;Lily Chen;Scott Blanchard;Alan D. Frankel

  • Preparation of isotopically labeled ribonucleotides for multidimensional NMR spectroscopy of RNA

    Robert T. Batey;Maki Inada;Elizabeth Kujawinski;Joseph D. Puglisi

  • Paromomycin binding induces a local conformational change in the A-site of 16 S rRNA.

    Dominique Fourmy;Satoko Yoshizawa;Joseph D. Puglisi

  • Real-time tRNA transit on single translating ribosomes at codon resolution

    Sotaro Uemura;Colin Echeverría Aitken;Colin Echeverría Aitken;Jonas Korlach;Benjamin A. Flusberg

  • The Pathway of HCV IRES-Mediated Translation Initiation

    Geoff A. Otto;Joseph D. Puglisi

  • Binding of neomycin-class aminoglycoside antibiotics to the A-site of 16 s rRNA

    Dominique Fourmy;Michael I Recht;Joseph D Puglisi

  • RNA Sequence Determinants for Aminoglycoside Binding to an A-site rRNA Model Oligonucleotide

    Michael I. Recht;Dominique Fourmy;Scott C. Blanchard;Kam D. Dahlquist

  • Structure of HCV IRES domain II determined by NMR.

    Peter J Lukavsky;Peter J Lukavsky;Insil Kim;Geoff A Otto;Joseph D Puglisi

  • Recognition of the codon-anticodon helix by ribosomal RNA.

    Satoko Yoshizawa;Dominique Fourmy;Joseph D. Puglisi

  • Basis for prokaryotic specificity of action of aminoglycoside antibiotics.

    Michael I. Recht;Stephen Douthwaite;Joseph D. Puglisi

  • tRNA structure and aminoacylation efficiency.

    Richard Giegé;Joseph D. Puglisi;Catherine Florentz

  • Synthesis and purification of large amounts of RNA oligonucleotides.

    J R Wyatt;M Chastain;J D Puglisi

Frequent Co-Authors

Sean T. O’Leary
Sean T. O’Leary University of Colorado Anschutz Medical Campus
Scott C. Blanchard
Scott C. Blanchard St. Jude Children's Research Hospital
Steven Chu
Steven Chu Stanford University
Alexander D. Johnson
Alexander D. Johnson University of California, San Francisco
Ignacio Tinoco
Ignacio Tinoco University of California, Berkeley
Richard Giegé
Richard Giegé Centre national de la recherche scientifique, CNRS
Catherine Florentz
Catherine Florentz University of Strasbourg
John F. Atkins
John F. Atkins University College Cork
Gideon Rechavi
Gideon Rechavi Sheba Medical Center

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