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Molecular Biology

D-Index
108
Citations
38646
World Ranking
401
National Ranking
229

Biology and Biochemistry

D-Index
111
Citations
47088
World Ranking
935
National Ranking
584

Research.com Recognitions

  • 2015 - Fellow, National Academy of Inventors
  • 2005 - Member of the National Academy of Medicine (NAM)
  • 1990 - Member of the National Academy of Sciences
  • 1987 - Fellow of the American Academy of Arts and Sciences
  • 1985 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1970 - Fellow of Alfred P. Sloan Foundation

Overview

Paul Schimmel is affiliated with the Scripps Research Institute in the United States and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research focuses primarily on molecular biology, with significant exploration into cancer research, hematology, and immunology.

The main topics covered in their work include:

  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • RNA research and splicing
  • Genomics and phylogenetic studies
  • Cancer-related molecular mechanisms research
  • Platelet disorders and treatments
  • Cell adhesion molecules research

Paul Schimmel frequently publishes in the following venues:

  • Nature Cell Biology
  • Nucleic Acids Research
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Science Translational Medicine

Notable recent papers include:

  • "PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications" (2021, Nature Cell Biology)
  • "tRNA renovatio: Rebirth through fragmentation" (2023, Molecular Cell)
  • "Regulation of ex-translational activities is the primary function of the multi-tRNA synthetase complex" (2020, Nucleic Acids Research)
  • "Inflammatory platelet production stimulated by tyrosyl-tRNA synthetase mimicking viral infection" (2022, Proceedings of the National Academy of Sciences)
  • "Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2" (2023, Nature Cell Biology)

Frequent co-authors working with Paul Schimmel include:

  • Bernhard Kuhle
  • Xiang-Lei Yang
  • Haissi Cui
  • Jolene K. Diedrich
  • John R. Yates

Throughout their career, Paul Schimmel has been recognized with several awards and honors:

  • Fellow, National Academy of Inventors (2015)
  • Member of the National Academy of Medicine (NAM) (2005)
  • Member of the National Academy of Sciences (1990)
  • Fellow of the American Academy of Arts and Sciences (1987)
  • Fellow of the American Association for the Advancement of Science (AAAS) (1985)
  • Fellow of Alfred P. Sloan Foundation (1970)

Best Publications

  • Biophysical Chemistry: Part II: Techniques for the Study of Biological Structure and Function

    Charles R. Cantor;Paul R. Schimmel

  • Biophysical chemistry. Part III, The behavior of biologicalmacromolecules

    Charles R. Cantor;Paul R. Schimmel

  • Chimeric peptides for neuropeptide delivery through the blood-brain barrier.

    William M. Pardridge;Paul R. Schimmel

  • A simple structural feature is a major determinant of the identity of a transfer RNA

    Ya-Ming Hou;Paul Schimmel

  • Aminoacyl-tRNA synthetases: general features and recognition of transfer RNAs.

    Paul R. Schimmel;Dieter Söll

  • Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration

    Jeong Woong Lee;Kirk Beebe;Leslie A. Nangle;Jaeseon Jang

  • Two distinct cytokines released from a human aminoacyl-tRNA synthetase.

    Keisuke Wakasugi;Paul Schimmel

  • Aminoacyl tRNA synthetases: general scheme of structure-function relationships in the polypeptides and recognition of transfer RNAs

    Paul Schimmel

  • Aminoacyl tRNA synthetases and their connections to disease

    Sang Gyu Park;Paul Schimmel;Sunghoon Kim

  • An operational RNA code for amino acids and possible relationship to genetic code.

    Paul Schimmel;Richard Giege;Dino Moras;Shigeyuki Yokoyama

  • Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration

    Ryuta Ishimura;Gabor Nagy;Ivan Dotu;Huihao Zhou

  • Enzyme structure with two catalytic sites for double-sieve selection of substrate.

    Osamu Nureki;Dmitry G. Vassylyev;Masaru Tateno;Atsushi Shimada

  • New functions of aminoacyl-tRNA synthetases beyond translation

    Min Guo;Xiang-Lei Yang;Paul Schimmel

  • The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis

    Paul Schimmel

  • Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis.

    Atsushi Otani;Karen Kinder;Karla Ewalt;Francella J Otero

  • Essential nontranslational functions of tRNA synthetases

    Min Guo;Paul Schimmel

  • Aminoacylation of RNA minihelices with alanine

    Christopher Francklyn;Paul Schimmel

  • A human aminoacyl-tRNA synthetase as a regulator of angiogenesis

    Keisuke Wakasugi;Bonnie M. Slike;John Hood;Atsushi Otani

  • Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway.

    Volker Döring;Henning D. Mootz;Leslie A. Nangle;Tamara L. Hendrickson

  • Conformational energies and configurational statistics of copolypeptides containing L-proline.

    Paul R. Schimmel;Paul J. Flory

Frequent Co-Authors

Xiang-Lei Yang
Xiang-Lei Yang Scripps Research Institute
Karin Musier-Forsyth
Karin Musier-Forsyth The Ohio State University
Valérie de Crécy-Lagard
Valérie de Crécy-Lagard University of Florida
Kiyotaka Shiba
Kiyotaka Shiba Japanese Foundation For Cancer Research
Duncan E. McRee
Duncan E. McRee Scripps Research Institute
Lynne Regan
Lynne Regan University of Edinburgh
Litao Sun
Litao Sun Southeast University
Martin Friedlander
Martin Friedlander Scripps Research Institute
Robert E. Kingston
Robert E. Kingston Harvard University

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