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Chemistry

D-Index
65
Citations
11955
World Ranking
7855
National Ranking
448

Research.com Recognitions

  • 2014 - Interdisciplinary Prize, Royal Society of Chemistry (UK)

Overview

Sabine L. Flitsch is affiliated with the University of Manchester in the United Kingdom. Their research spans multiple disciplines within biochemistry, genetics, molecular biology, and chemistry, with a particular focus on enzyme catalysis and glycosylation. The analytical and synthetic approaches in their work often involve the study of molecular biology, organic chemistry, biomedical engineering, biotechnology, and pharmacology.

The main topics of Sabine L. Flitsch's scientific work include:

  • Enzyme Catalysis and Immobilization
  • Glycosylation and Glycoproteins Research
  • Carbohydrate Chemistry and Synthesis
  • Chemical Synthesis and Analysis
  • Enzyme Production and Characterization
  • Microbial Metabolic Engineering and Bioproduction
  • Click Chemistry and Applications

Their notable recent publications illustrate involvement in biocatalysis and synthetic enzymology. Key papers include:

  • "Biocatalysis," 2021, published in Nature Reviews Methods Primers
  • "RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades," 2021, Nature Catalysis
  • "Enzymatic Late-Stage Modifications: Better Late Than Never," 2021, Angewandte Chemie International Edition
  • "Biocatalytic amide bond formation," 2023, Green Chemistry
  • "The Time and Place for Nature in Drug Discovery," 2022, JACS Au

Frequent collaborators in Sabine L. Flitsch's body of work include:

  • Nicholas J. Turner
  • Ashley P. Mattey
  • Kun Huang
  • Andrea Marchesi
  • Fabio Parmeggiani

Flitsch's research has been published predominantly in high-impact venues, including:

  • Angewandte Chemie
  • Angewandte Chemie International Edition
  • JACS Au
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Catalysis

The scientist received the Interdisciplinary Prize from the Royal Society of Chemistry (UK) in 2014, reflecting recognition in their field.

Best Publications

  • Structural studies on transmembrane proteins. 2. Spin labeling of bacteriorhodopsin mutants at unique cysteines.

    C. Altenbach;S.L. Flitsch;H.G. Khorana;W.L. Hubbell

  • Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

    Lorna J. Hepworth;Nicholas J. Turner;Sabine L. Flitsch

  • Selective oxidation of monosaccharide derivatives to uronic acids

    Nicola J. Davis;Sabine L. Flitsch

  • Cytochromes P450 as useful biocatalysts: addressing the limitations

    Elaine O'Reilly;Valentin Köhler;Sabine L. Flitsch;Nicholas J. Turner

  • Identification of a New Class of Cytochrome P450 from a Rhodococcus sp.

    Gareth A. Roberts;Gideon Grogan;Andy Greter;Sabine L. Flitsch

  • Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering.

    Barry D Moore;Lorna Stevenson;Alan Watt;Sabine Flitsch

  • RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades.

    William Finnigan;Lorna J Hepworth;Sabine L Flitsch;Nicholas J Turner

  • One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

    Shahed Hussain;Andrew M. Hill;Lorna J. Hepworth

  • Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing

    P. Both;A. P. Green;C. J. Gray;R. Sardzik

  • Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

    Gloria Lopez-Castejon;Nadia M. Luheshi;Vincent Compan;Stephen High

  • Quaternary ammonium compounds as water channel blockers. Specificity, potency, and site of action.

    Frank J.M. Detmers;Bert L. de Groot;E. Matthias Müller;Andrew Hinton

  • Advancing solutions to the carbohydrate sequencing challenge

    Christopher J. Gray;Lukasz G. Migas;Perdita E. Barran;Kevin Pagel

  • A recycling pathway for cyanogenic glycosides evidenced by the comparative metabolic profiling in three cyanogenic plant species

    Martina Pičmanová;Elizabeth Heather Neilson;Mohammed Saddik Motawia;Carl Erik Olsen

  • Applications of ion mobility mass spectrometry for high throughput, high resolution glycan analysis

    C.J. Gray;B. Thomas;R. Upton;L.G. Migas

  • Evidence That Bilayer Bending Rigidity Affects Membrane Protein Folding

    P J Booth;M L Riley;S L Flitsch;Richard H Templer

  • A Self-sufficient Cytochrome P450 with a Primary Structural Organization That Includes a Flavin Domain and a [2Fe-2S] Redox Center

    Gareth A. Roberts;Ayhan Çelik;Dominic J.B. Hunter;Tobias W.B. Ost

  • Glycoarrays—tools for determining protein–carbohydrate interactions and glycoenzyme specificity

    Nicolas Laurent;Josef Voglmeir;Sabine L. Flitsch

  • Intermediates in the folding of the membrane protein bacteriorhodopsin

    P J Booth;S L Flitsch;L J Stern;L J Stern;D A Greenhalgh

  • Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum.

    Benedict C. S. Cross;Craig McKibbin;Anna C. Callan;Peristera Roboti

  • Slow alpha helix formation during folding of a membrane protein.

    M L Riley;B A Wallace;S L Flitsch;P J Booth

  • Selective in vitro glycosylation of recombinant proteins: semi-synthesis of novel homogeneous glycoforms of human erythropoietin.

    Derek Macmillan;Roslyn M Bill;Karen A Sage;Dominic Fern

  • Protease-catalyzed peptide synthesis on solid support.

    Rein V Ulijn;Beatriz Baragaña;Peter J Halling;Sabine L Flitsch

  • Enzymatic Late-Stage Modifications: Better Late Than Never

    Elvira Romero;Bethan S. Jones;Bethany N. Hogg;Arnau Rué Casamajo

Frequent Co-Authors

Nicholas J. Turner
Nicholas J. Turner University of Manchester
Gideon Grogan
Gideon Grogan University of York
Rein V. Ulijn
Rein V. Ulijn City University of New York
Iain B. H. Wilson
Iain B. H. Wilson BOKU University
Peter J. Halling
Peter J. Halling University of Strathclyde
Roslyn M. Bill
Roslyn M. Bill Aston University
Perdita E. Barran
Perdita E. Barran University of Manchester
Stephen High
Stephen High University of Manchester
Malcolm D. Walkinshaw
Malcolm D. Walkinshaw University of Edinburgh
Robert A. Field
Robert A. Field University of Manchester

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