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Chemistry

D-Index
49
Citations
8013
World Ranking
14892
National Ranking
832

Overview

Gideon Grogan is a researcher affiliated with the University of York in the United Kingdom. Their work primarily spans across the fields of Biochemistry, Genetics and Molecular Biology, and Chemistry, with a strong focus on Molecular Biology and Organic Chemistry. This multidisciplinary approach supports investigations into several subfields including Inorganic Chemistry, Materials Chemistry, and Pharmacology.

The scientist's main research topics include:

  • Enzyme Catalysis and Immobilization
  • Metal-Catalyzed Oxygenation Mechanisms
  • Amino Acid Enzymes and Metabolism
  • Biochemical and Molecular Research
  • Enzyme Structure and Function
  • Synthesis and Catalytic Reactions
  • Microbial Natural Products and Biosynthesis

Recent publications by Grogan demonstrate research output in diverse areas of catalysis and enzymatic processes. Notable papers include:

  • "Multifunctional biocatalyst for conjugate reduction and reductive amination" (2022) published in Nature
  • "Reductive aminations by imine reductases: from milligrams to tons" (2022) published in Chemical Science
  • "Hemoprotein Catalyzed Oxygenations: P450s, UPOs, and Progress toward Scalable Reactions" (2021) published in JACS Au
  • "Chromoselective Photocatalysis Enables Stereocomplementary Biocatalytic Pathways" (2021) published in Angewandte Chemie International Edition
  • "Biocatalytic Synthesis of Moclobemide Using the Amide Bond Synthetase McbA Coupled with an ATP Recycling System" (2020) published in ACS Catalysis

Grogan frequently publishes in several high-impact scientific journals, with repeated contributions to:

  • ACS Catalysis
  • Angewandte Chemie International Edition
  • ChemCatChem
  • Angewandte Chemie
  • Chemical Science

Collaborations are a significant aspect of Grogan's research output. Frequent co-authors include William P. Unsworth, Jared Cartwright, Balázs Pogrányi, Aníbal Cuetos, and Tamara Mielke. These collaborations suggest extensive interdisciplinary cooperation and a broad research network.

Best Publications

  • Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products.

    Diego Ghislieri;Anthony P. Green;Marta Pontini;Simon C. Willies

  • A reductive aminase from Aspergillus oryzae

    Godwin Aleku;Henry Wing-Hong Man;Juan Mangas-Sanchez

  • Imine reductases (IREDs)

    Juan Mangas-Sanchez;Sarah L Montgomery;Godwin A Aleku

  • Identification of a New Class of Cytochrome P450 from a Rhodococcus sp.

    Gareth A. Roberts;Gideon Grogan;Andy Greter;Sabine L. Flitsch

  • Oxidoreductase-Catalyzed Synthesis of Chiral Amines

    Mahesh D. Patil;Gideon Grogan;Andreas Bommarius;Hyungdon Yun

  • An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines.

    Shahed Hussain;Friedemann Leipold;Henry Man;Elizabeth Wells

  • InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines.

    Gideon Grogan;Nicholas J. Turner

  • Recent Advances in ω-Transaminase-Mediated Biocatalysis for the Enantioselective Synthesis of Chiral Amines

    Mahesh D. Patil;Gideon Grogan;Andreas Bommarius;Hyungdon Yun

  • Cytochromes P450: exploiting diversity and enabling application as biocatalysts.

    Gideon Grogan

  • Synthesis of chiral amines using redox biocatalysis.

    Gideon Grogan

  • Multifunctional biocatalyst for conjugate reduction and reductive amination

    Unknown

  • Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis

    Godwin A. Aleku;Henry Man;Friedemann Leipold

  • Enzyme‐Catalysed Synthesis of Secondary and Tertiary Amides

    Mark R. Petchey;Gideon Grogan

  • Structure and Activity of NADPH-Dependent Reductase Q1EQE0 from Streptomyces kanamyceticus, which Catalyses the R-Selective Reduction of an Imine Substrate

    María Rodríguez‐Mata;Annika Frank;Elizabeth Wells;Friedemann Leipold

  • Glycoprotein Labeling Using Engineered Variants of Galactose Oxidase Obtained by Directed Evolution.

    Julie B. Rannes;Avgousta Ioannou;Simon C. Willies;Gideon Grogan

  • NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application.

    Mahima Sharma;Juan Mangas-Sanchez;Nicholas Turner;Gideon James Grogan

  • Ligation independent cloning (LIC) as a rapid route to families of recombinant biocatalysts from sequenced prokaryotic genomes

    Daniel Bonsor;Stephanie F. Butz;Julianna Solomons;Stephanie Grant

  • Emergent mechanistic diversity of enzyme-catalysed β-diketone cleavage

    Gideon Grogan

  • The structure of monoamine oxidase from Aspergillus niger provides a molecular context for improvements in activity obtained by directed evolution.

    K.E Atkin;R Reiss;Koehler;K.R Bailey

  • A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases

    Mahima Sharma;Juan Mangas-Sanchez;Godwin A. Aleku

  • The biocatalytic reactions of Beauveria spp.

    Gideon J Grogan;Herbert L Holland

  • Structural insights into substrate specificity and solvent tolerance in alcohol dehydrogenase ADH-'A' from Rhodococcus ruber DSM 44541.

    Martin Karabec;Andrzej L. Łyskowski;Katharina C. Tauber;Georg Steinkellner

Frequent Co-Authors

Nicholas J. Turner
Nicholas J. Turner University of Manchester
Sabine L. Flitsch
Sabine L. Flitsch University of Manchester
Wolfgang Kroutil
Wolfgang Kroutil University of Graz
Neil C. Bruce
Neil C. Bruce University of York
Bernhard Hauer
Bernhard Hauer University of Stuttgart
Ian J. S. Fairlamb
Ian J. S. Fairlamb University of York
Frank Hollmann
Frank Hollmann Delft University of Technology
Simon Parsons
Simon Parsons University of Edinburgh
Chandra S. Verma
Chandra S. Verma Agency for Science, Technology and Research
Ian J. Jackson
Ian J. Jackson University of Edinburgh

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