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Biology and Biochemistry

D-Index
61
Citations
11768
World Ranking
11479
National Ranking
875

Overview

Stephen High is a researcher affiliated with the University of Manchester in the United Kingdom. Their academic work primarily focuses on Biochemistry, Genetics and Molecular Biology, with specific contributions to Molecular Biology, Cell Biology, Immunology, Ecology, and Genetics.

Their research spans several key topics including:

  • Endoplasmic Reticulum Stress and Disease
  • Cellular transport and secretion
  • Bacteriophages and microbial interactions
  • Glycosylation and Glycoproteins Research
  • Bacterial Genetics and Biotechnology
  • SARS-CoV-2 and COVID-19 Research
  • Interferon and immune responses

Stephen High has contributed to multiple recent scientific papers, including:

  • An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum (2021) published in Communications Biology
  • Membrane protein biogenesis at the ER: the highways and byways (2021) published in FEBS Journal
  • Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor (2021) published in Journal of Cell Science
  • Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F (2020) published in The Journal of Organic Chemistry
  • Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle (2020) published in PLoS Biology

Their frequent co-authors include:

  • Sarah O'Keefe
  • Wei Shi
  • Kwabena B. Duah
  • Guanghui Zong
  • Peristera Roboti

Stephen High often publishes in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Cell Science
  • FEBS Journal
  • eLife
  • SSRN Electronic Journal

Best Publications

  • Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

    Andrew R. J. Young;Edmond Y. W. Chan;Xiao Wen Hu;Robert Köchl

  • Interaction of the thiol-dependent reductase ERp57 with nascent glycoproteins

    Jason D. Oliver;Fimme J. van der Wal;Neil J. Bulleid;Stephen High

  • ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin.

    Jason D. Oliver;H. Llewelyn Roderick;David H. Llewellyn;Stephen High

  • The complete amino acid sequence of the human erythrocyte membrane anion-transport protein deduced from the cDNA sequence.

    M J A Tanner;P G Martin;S High

  • The Escherichia coli SRP and SecB targeting pathways converge at the translocon

    Quido A. Valent;Pier A. Scotti;Stephen High;Jan Willem L De Gier

  • Early events in preprotein recognition in E. coli: interaction of SRP and trigger factor with nascent polypeptides.

    Q. A. Valent;D. A. Kendall;S. High;R. Kusters

  • An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY.

    J Luirink;C M ten Hagen-Jongman;C C van der Weijden;B Oudega

  • Signal-sequence recognition by an Escherichia coli ribonucleoprotein complex.

    Joen Luirink;Stephen High;Heather Wood;Angelika Giner

  • Delivering proteins for export from the cytosol

    Benedict C S Cross;Irmgard Sinning;Joen Luirink;Stephen High

  • Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

    Gloria Lopez-Castejon;Nadia M. Luheshi;Vincent Compan;Stephen High

  • Glycoprotein folding in the endoplasmic reticulum: a tale of three chaperones?

    Stephen High;Fabienne J.L Lecomte;Sarah J Russell;Benjamin M Abell

  • Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence.

    S High;B Martoglio;D Görlich;S S Andersen

  • The translocation, folding, assembly and redox-dependent degradation of secretory and membrane proteins in semi-permeabilized mammalian cells.

    R Wilson;A J Allen;J Oliver;J L Brookman

  • The methionine-rich domain of the 54 kDa subunit of signal recognition particle is sufficient for the interaction with signal sequences.

    Henrich Lütcke;Stephen High;Karin Römisch;Anthony J. Ashford

  • The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER.

    Belinda S. Hall;Kirsti Hill;Michael McKenna;Joy Ogbechi

  • The Thiol-dependent Reductase ERp57 Interacts Specifically with N-Glycosylated Integral Membrane Proteins

    John G. Elliott;Jason D. Oliver;Stephen High

  • The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment

    Julia J A Greenfield;Stephen High

  • Signal recognition particle mediates post-translational targeting in eukaryotes

    Benjamin M Abell;Martin R Pool;Oliver Schlenker;Irmgard Sinning

  • Bat3 promotes the membrane integration of tail-anchored proteins

    Pawel Leznicki;Anne Clancy;Blanche Schwappach;Stephen High

  • Role of calnexin in the glycan‐independent quality control of proteolipid protein

    Eileithyia Swanton;Stephen High;Philip Woodman

Frequent Co-Authors

Bernhard Dobberstein
Bernhard Dobberstein Heidelberg University
Joen Luirink
Joen Luirink Vrije Universiteit Amsterdam
Richard Zimmermann
Richard Zimmermann Saarland University
Michael J. McKenna
Michael J. McKenna Massachusetts Eye and Ear Infirmary
Sabine L. Flitsch
Sabine L. Flitsch University of Manchester
Dirk Görlich
Dirk Görlich Max Planck Society
Tom A. Rapoport
Tom A. Rapoport Harvard University
Michael J. A. Tanner
Michael J. A. Tanner University of Bristol
Caroline Demangel
Caroline Demangel Institut Pasteur
Emmanuel J. H. J. Wiertz
Emmanuel J. H. J. Wiertz Utrecht University

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