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Chemistry

D-Index
111
Citations
38237
World Ranking
789
National Ranking
316

Research.com Recognitions

  • 2005 - Member of the National Academy of Sciences
  • 2001 - Fellow of the American Academy of Arts and Sciences
  • 1973 - Fellow of Alfred P. Sloan Foundation

Overview

Wayne L. Hubbell is affiliated with the University of California, Los Angeles in the United States. Their research primarily spans biochemistry, genetics, and molecular biology, with a strong focus on molecular biology, biophysics, atomic and molecular physics, optics, immunology, and virology.

Their work encompasses various scientific topics, including:

  • Electron Spin Resonance Studies
  • Receptor Mechanisms and Signaling
  • Spectroscopy and Quantum Chemical Studies
  • Protein Structure and Dynamics
  • Lipid Membrane Structure and Behavior
  • HIV Research and Treatment
  • Lanthanide and Transition Metal Complexes

Their recent publications include the following papers:

  • "Synthetic nanobodies as angiotensin receptor blockers" (2020) in Proceedings of the National Academy of Sciences
  • "Viewing rare conformations of the β 2 adrenergic receptor with pressure-resolved DEER spectroscopy" (2020) in Proceedings of the National Academy of Sciences
  • "Ligand efficacy modulates conformational dynamics of the µ-opioid receptor" (2024) in Nature
  • "DEER Analysis of GPCR Conformational Heterogeneity" (2021) in Biomolecules
  • "Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer" (2022) in Nature Communications

Frequent publication venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Nature Communications
  • Biophysical Journal
  • Nature

Wayne L. Hubbell has collaborated frequently with several researchers, including:

  • Michael D. Bridges
  • Matthias Elgeti
  • Ruiqiong Guo
  • Heedeok Hong
  • Tobin R. Sosnick

The scientist's career includes recognition with awards such as:

  • Member of the National Academy of Sciences (2005)
  • Fellow of the American Academy of Arts and Sciences (2001)
  • Fellow of the Alfred P. Sloan Foundation (1973)

Best Publications

  • Molecular motion in spin-labeled phospholipids and membranes

    W L Hubbell;H M McConnell

  • Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin

    David L. Farrens;Christian Altenbach;Ke Yang;Wayne L. Hubbell

  • Identifying conformational changes with site-directed spin labeling.

    Wayne L. Hubbell;David S. Cafiso;Christian Altenbach

  • Motion of spin-labeled side chains in T4 lysozyme. Correlation with protein structure and dynamics.

    Hassane S. Mchaourab;Michael A. Lietzow;Kalman Hideg;Wayne L. Hubbell

  • Recent advances in site-directed spin labeling of proteins

    Wayne L Hubbell;Adrian Gross;Ralf Langen;Michael A Lietzow

  • Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

    Yanyong Kang;X. Edward Zhou;Xiang Gao;Yuanzheng He

  • Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling

    Aashish Manglik;Tae Hun Kim;Matthieu Masureel;Christian Altenbach

  • Transmembrane protein structure: spin labeling of bacteriorhodopsin mutants

    C Altenbach;T Marti;HG Khorana;WL Hubbell

  • Electrostatic interactions in membranes and proteins.

    Barry H. Honig;Wayne L. Hubbell;Ross F. Flewelling

  • A collision gradient method to determine the immersion depth of nitroxides in lipid bilayers: application to spin-labeled mutants of bacteriorhodopsin.

    C Altenbach;D A Greenhalgh;H G Khorana;W L Hubbell

  • Watching proteins move using site-directed spin labeling

    Wayne L Hubbell;Hassane S Mchaourab;Christian Altenbach;Michael A Lietzow

  • High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation

    Christian Altenbach;Ana Karin Kusnetzow;Oliver P. Ernst;Klaus Peter Hofmann

  • Investigation of structure and dynamics in membrane proteins using site-directed spin labeling

    Wayne L. Hubbell;Christian Altenbach

  • A new spin on protein dynamics.

    Linda Columbus;Wayne L Hubbell

  • The membrane dipole potential in a total membrane potential model. Applications to hydrophobic ion interactions with membranes

    R.F. Flewelling;W.L. Hubbell

  • Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors

    X. Edward Zhou;X. Edward Zhou;Yuanzheng He;Parker W. de Waal;Xiang Gao

  • Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking.

    Wayne L Hubbell;Christian Altenbach;Cheryl M Hubbell;H Gobind Khorana

  • Structural studies on transmembrane proteins. 2. Spin labeling of bacteriorhodopsin mutants at unique cysteines.

    C. Altenbach;S.L. Flitsch;H.G. Khorana;W.L. Hubbell

  • Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: a site-directed spin-labeling study.

    C Altenbach;K Yang;D L Farrens;Z T Farahbakhsh

  • Immunospecific targeting of liposomes to cells: a novel and efficient method for covalent attachment of Fab' fragments via disulfide bonds.

    Francis J. Martin;Wayne L. Hubbell;Demetrios Papahadjopoulos

Frequent Co-Authors

Christian Altenbach
Christian Altenbach University of California, Los Angeles
Vsevolod V. Gurevich
Vsevolod V. Gurevich Vanderbilt University
H. Ronald Kaback
H. Ronald Kaback University of California, Los Angeles
David S. Cafiso
David S. Cafiso University of Virginia
Judith Klein-Seetharaman
Judith Klein-Seetharaman Arizona State University
Duilio Cascio
Duilio Cascio University of California, Los Angeles
Harden M. McConnell
Harden M. McConnell Stanford University
Ralf Langen
Ralf Langen University of Southern California
Heidi E. Hamm
Heidi E. Hamm Vanderbilt University

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