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Chemistry

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81
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3274
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1080

Biology and Biochemistry

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82
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Overview

Thomas P. Sakmar is affiliated with Rockefeller University in the United States. Their research spectrum primarily encompasses the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, contributing notably with 57 and 46 publications respectively.

The scientist's work delves into several subfields including Molecular Biology, Radiology, Nuclear Medicine and Imaging, Cellular and Molecular Neuroscience, Oncology, and Infectious Diseases. Their research interests span a wide range of topics, among which Receptor Mechanisms and Signaling, Monoclonal and Polyclonal Antibodies Research, Neuropeptides and Animal Physiology, Retinal Development and Disorders, Chemical Synthesis and Analysis, SARS-CoV-2 detection and testing, and Click Chemistry and Applications are prominent.

Thomas P. Sakmar has contributed papers such as Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma (2020, Clinical Cancer Research), Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling (2020, Journal of Biological Chemistry), Autoantibodies targeting G protein-coupled receptors: An evolving history in autoimmunity. Report of the 4th international symposium (2023, Autoimmunity Reviews), Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins (2022, Pharmacological Reviews), and Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain (2021, Science Advances).

Frequent coauthors who have collaborated extensively with Thomas P. Sakmar include Thomas Huber, Emilie Ceraudo, Ilana B. Kotliar, Manija A. Kazmi, and Jordan M. Mattheisen.

Thomas P. Sakmar's publications appear regularly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Science Advances, Methods in Molecular Biology, Autoimmunity Reviews, and the Journal of Biological Chemistry.

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

  • Molecular Biology
  • Radiology, Nuclear Medicine and Imaging
  • Cellular and Molecular Neuroscience
  • Oncology
  • Infectious Diseases

  • Receptor Mechanisms and Signaling
  • Monoclonal and Polyclonal Antibodies Research
  • Neuropeptides and Animal Physiology
  • Retinal Development and Disorders
  • Chemical Synthesis and Analysis
  • SARS-CoV-2 detection and testing
  • Click Chemistry and Applications

  • Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma (2020, Clinical Cancer Research)
  • Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling (2020, Journal of Biological Chemistry)
  • Autoantibodies targeting G protein-coupled receptors: An evolving history in autoimmunity. Report of the 4th international symposium (2023, Autoimmunity Reviews)
  • Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins (2022, Pharmacological Reviews)
  • Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain (2021, Science Advances)

  • Thomas Huber
  • Emilie Ceraudo
  • Ilana B. Kotliar
  • Manija A. Kazmi
  • Jordan M. Mattheisen

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Advances
  • Methods in Molecular Biology
  • Autoimmunity Reviews
  • Journal of Biological Chemistry

Best Publications

  • Defeating Alzheimer's disease and other dementias: a priority for European science and society

    Bengt Winblad;Bengt Winblad;Philippe Amouyel;Sandrine Andrieu;Clive Ballard

  • AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

    G A Donzella;D Schols;S W Lin;J A Esté

  • Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin

    T P Sakmar;R R Franke;H G Khorana

  • A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

    Tatjana Dragic;Alexandra Trkola;Daniah A. D. Thompson;Emmanuel G. Cormier

  • Update on Alzheimer's Disease Therapy and Prevention Strategies

    W. Vallen Graham;Alessandra Bonito-Oliva;Thomas P. Sakmar

  • Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin

    S S Karnik;T P Sakmar;H B Chen;H G Khorana

  • Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F

    Søren P. Sheikh;Tatyana A. Zvyaga;Olivier Lichtarge;Thomas P. Sakmar

  • Rhodopsin mutants that bind but fail to activate transducin

    RR Franke;B Konig;TP Sakmar;HG Khorana

  • CXCR7/CXCR4 heterodimer constitutively recruits β-arrestin to enhance cell migration

    Fabien M. Décaillot;Manija A. Kazmi;Ying Lin;Sarmistha Ray-Saha

  • Rhodopsin: Structural Basis of Molecular Physiology

    Santosh T. Menon;May Han;Thomas P. Sakmar

  • Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin.

    R.R. Franke;T.P. Sakmar;R.M. Graham;H.G. Khorana

  • G protein-coupled receptors self-assemble in dynamics simulations of model bilayers.

    Xavier Periole;Thomas Huber;Siewert-Jan Marrink;Thomas P. Sakmar

  • Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

    Christopher T. Veldkamp;Christoph Seibert;Francis C. Peterson;Norberto B. De la Cruz

  • Curvature and hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes

    Ana Vitória Botelho;Thomas Huber;Thomas P. Sakmar;Michael F. Brown

  • Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants.

    Karim Fahmy;Frank Jager;Mareike Beck;Tatyana A. Zvyaga

  • A single amino acid substitution in rhodopsin (lysine 248----leucine) prevents activation of transducin.

    R R Franke;T P Sakmar;D D Oprian;H G Khorana

  • Amino-Terminal Substitutions in the CCR5 Coreceptor Impair gp120 Binding and Human Immunodeficiency Virus Type 1 Entry

    Tatjana Dragic;Alexandra Trkola;Steven W. Lin;Kirsten A. Nagashima

  • Rhodopsin: insights from recent structural studies.

    Thomas P. Sakmar;Santosh T. Menon;Ethan P. Marin;Elias S. Awad

  • Total synthesis and expression of a gene for the α-subunit of bovine rod outer segment guanine nucleotide-binding protein (transducin)

    Thomas P. Sakmar;H.Gobind Khorana

  • Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma

    Amanda R Moore;Emilie Ceraudo;Jessica J Sher;Youxin Guan

  • Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry

    Fotini Tsamis;Svetlana Gavrilov;Francis Kajumo;Christoph Seibert

Frequent Co-Authors

Friedrich Siebert
Friedrich Siebert University of Freiburg
He Tian
He Tian Zhejiang University
Steven O. Smith
Steven O. Smith Stony Brook University
John P. Moore
John P. Moore Cornell University
Mordechai Sheves
Mordechai Sheves Weizmann Institute of Science
Thue W. Schwartz
Thue W. Schwartz University of Copenhagen
Caroline Graff
Caroline Graff Karolinska University Hospital
Bengt Winblad
Bengt Winblad Karolinska Institute
Yu Chen
Yu Chen New York University

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