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Biology and Biochemistry

D-Index
43
Citations
8739
World Ranking
19372
National Ranking
7906

Overview

Ann Dean is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with contributions also intersecting Medicine.

Their subfield expertise includes Molecular Biology, Genetics, Cancer Research, Plant Science, and Physiology.

The main topics covered in their work are:

  • RNA modifications and cancer
  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing
  • Hemoglobinopathies and Related Disorders
  • Cancer-related molecular mechanisms research
  • Epigenetics and DNA Methylation
  • RNA and protein synthesis mechanisms

Ann Dean has contributed to several research articles published across various scientific venues. Recent notable publications include:

  • "The mRNA-Binding Protein IGF2BP1 Restores Fetal Hemoglobin in Cultured Erythroid Cells from Patients with β-Hemoglobin Disorders," 2020, Molecular Therapy - Methods & Clinical Development
  • "Embryonic erythropoiesis and hemoglobin switching require transcriptional repressor ETO2 to modulate chromatin organization," 2020, Nucleic Acids Research
  • "Enhancers, gene regulation, and genome organization," 2021, Genes & Development
  • "Enhancers navigate the three-dimensional genome to direct cell fate decisions," 2021, Current Opinion in Structural Biology
  • "Long noncoding RNA GATA2AS influences human erythropoiesis by transcription factor and chromatin landscape modulation," 2024, Blood

The frequent publication venues for their work include:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • Molecular Therapy - Methods & Clinical Development
  • Genes & Development

Ann Dean regularly collaborates with several researchers with multiple joint publications. Frequent co-authors include:

  • Juhyun Kim
  • Bingning Xie
  • Ivan Krivega
  • Xiang Guo

Best Publications

  • Receptor-mediated endocytosis of transferrin in K562 cells

    R D Klausner;J Van Renswoude;G Ashwell;C Kempf

  • Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.

    Wulan Deng;Wulan Deng;Jongjoo Lee;Hongxin Wang;Jeff Miller

  • Enhancers: five essential questions

    Len A. Pennacchio;Wendy Bickmore;Ann Dean;Marcelo A. Nobrega

  • Reactivation of developmentally silenced globin genes by forced chromatin looping.

    Wulan Deng;Wulan Deng;Jeremy W. Rupon;Ivan Krivega;Laura Breda

  • Identification of genetic elements that autonomously determine DNA methylation states

    Florian Lienert;Christiane Wirbelauer;Indrani Som;Ann Dean

  • Cell type specificity of chromatin organization mediated by CTCF and cohesin

    Chunhui Hou;Ryan Dale;Ann Dean

  • Enhancer and promoter interactions-long distance calls.

    Ivan Krivega;Ann Dean

  • Enhancer function: mechanistic and genome-wide insights come together.

    Jennifer L. Plank;Ann Dean

  • A Positive Role for NLI/Ldb1 in Long-Range β-Globin Locus Control Region Function

    Sang-Hyun Song;Chunhui Hou;Ann Dean

  • CTCF-dependent enhancer-blocking by alternative chromatin loop formation

    Chunhui Hou;Hui Zhao;Keiji Tanimoto;Ann Dean

  • On a chromosome far, far away: LCRs and gene expression.

    Ann Dean

  • Induction of hemoglobin accumulation in human K562 cells by hemin is reversible.

    Ann Dean;Francois Erard;Arthur B. Schneider;Alan N. Schechter

  • BRG1 requirement for long-range interaction of a locus control region with a downstream promoter.

    Shin Il Kim;Scott J. Bultman;Christine M. Kiefer;Ann Dean

  • Yeast alpha 2 repressor positions nucleosomes in TRP1/ARS1 chromatin.

    S Y Roth;A Dean;R T Simpson

  • Inducible transcription of five globin genes in K562 human leukemia cells.

    A Dean;T J Ley;R K Humphries;M Fordis

  • An insulator blocks spreading of histone acetylation and interferes with RNA polymerase II transfer between an enhancer and gene

    Hui Zhao;Ann Dean

  • Distinctive Signatures of Histone Methylation in Transcribed Coding and Noncoding Human β-Globin Sequences

    AeRi Kim;Christine M. Kiefer;Ann Dean

  • Role of LDB1 in the transition from chromatin looping to transcription activation

    Ivan Krivega;Ryan K. Dale;Ann Dean

  • Epigenetics of β-globin gene regulation

    Christine M. Kiefer;Chunhui Hou;Jane A. Little;Ann Dean

  • In the loop: long range chromatin interactions and gene regulation

    Ann Dean

Frequent Co-Authors

Gerd A. Blobel
Gerd A. Blobel Children's Hospital of Philadelphia
Alan N. Schechter
Alan N. Schechter National Institute of Diabetes and Digestive and Kidney Diseases
Mark Groudine
Mark Groudine Fred Hutchinson Cancer Research Center
Philip D. Gregory
Philip D. Gregory Sangamo BioSciences (United States)
Robert T. Simpson
Robert T. Simpson Pennsylvania State University
Dirk Schübeler
Dirk Schübeler Friedrich Miescher Institute
Wenqing Xu
Wenqing Xu University of Washington
Paul E. Love
Paul E. Love National Institutes of Health
Keji Zhao
Keji Zhao National Institutes of Health
Len A. Pennacchio
Len A. Pennacchio Lawrence Berkeley National Laboratory

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