World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
20774
World Ranking
16920
National Ranking
6972

Overview

Wenqing Xu is affiliated with the University of Washington in the United States. Their research spans several areas within medicine and biochemistry, genetics, and molecular biology, with a strong focus on molecular biology and infectious diseases.

Their recent publications include work on key topics related to viral structure and inhibition mechanisms. Some notable papers are:

  • Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors, 2020, Nature
  • Structure of the RNA-dependent RNA polymerase from COVID-19 virus, 2020, Science
  • Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase, 2020, Cell
  • Structure of Mpro from COVID-19 virus and discovery of its inhibitors, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Selective PP2A Enhancement through Biased Heterotrimer Stabilization, 2020, Cell

Wenqing Xu frequently collaborates with several co-authors, including Haitao Yang, Xiuna Yang, Luke W. Guddat, Zihe Rao, and Yao Zhao. These collaborations have contributed to a number of publications in leading journals.

Their work is commonly published in venues such as:

  • Nature Communications
  • Protein & Cell
  • Science
  • Cell
  • bioRxiv (Cold Spring Harbor Laboratory)

The primary fields Wenqing Xu covers are medicine and biochemistry, genetics, and molecular biology. Within these fields, subfields of particular focus include molecular biology, infectious diseases, oncology, genetics, and cardiology and cardiovascular medicine.

Their main research topics address critical areas in biomedical science, such as:

  • SARS-CoV-2 and COVID-19 research
  • Computational drug discovery methods
  • Peptidase inhibition and analysis
  • Glycosylation and glycoproteins research
  • Wnt/β-catenin signaling in development and cancer
  • Bacterial genetics and biotechnology
  • Viral gastroenteritis research and epidemiology

This profile reflects Wenqing Xu's contributions to understanding molecular mechanisms of viral pathogens and therapeutic targets, as well as their broader involvement in various biological research domains.

Best Publications

  • Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

    Zhenming Jin;Zhenming Jin;Xiaoyu Du;Yechun Xu;Yongqiang Deng

  • Three-dimensional structure of the tyrosine kinase c-Src

    Wenqing Xu;Stephen C. Harrison;Michael J. Eck

  • Structure of the RNA-dependent RNA polymerase from COVID-19 virus.

    Yan Gao;Yan Gao;Liming Yan;Yucen Huang;Fengjiang Liu

  • Crystal structures of c-Src reveal features of its autoinhibitory mechanism.

    Wenqing Xu;Amish Doshi;Ming Lei;Michael J Eck

  • Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.

    Quan Wang;Jiqin Wu;Haofeng Wang;Haofeng Wang;Yan Gao

  • Recognition of Antimicrobial Peptides by a Bacterial Sensor Kinase

    Martin W. Bader;Sarah Sanowar;Margaret E. Daley;Anna R. Schneider

  • beta-catenin destruction complex: insights and questions from a structural perspective.

    D Kimelman;W Xu

  • Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

    Uhn Soo Cho;Wenqing Xu

  • Crystal Structure of a β-Catenin/Tcf Complex

    Thomas A. Graham;Carole Weaver;Feng Mao;David Kimelman

  • Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding.

    H. E. Xu;M. A. Rould;Wenqing Xu;J. A. Epstein

  • Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations.

    Wenqing Xu;Mark A Rould;Susie Jun;Claude Desplan

  • Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex.

    Yi Xing;Wilson K. Clements;David Kimelman;Wenqing Xu

  • Mechanistic insights from structural studies of β-catenin and its binding partners

    Wenqing Xu;David Kimelman

  • MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex

    Tian Lin Cheng;Zhizhi Wang;Qiuming Liao;Ying Zhu

  • Targeted Disruption of the BCL9/β-Catenin Complex Inhibits Oncogenic Wnt Signaling

    Kohichi Takada;Di Zhu;Gregory H. Bird;Kumar Sukhdeo

  • Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination

    Zhizhi Wang;Gregory A. Michaud;Zhihong Cheng;Yue Zhang

  • Crystal Structure of a Full-Length beta-Catenin

    Yi Xing;Ken Ichi Takemaru;Jing Liu;Jason D. Berndt

  • Structure and function of the PP2A-shugoshin interaction

    Zheng Xu;Bulent Cetin;Martin Anger;Uhn Soo Cho

  • Crystal Structure of a β-Catenin/BCL9/Tcf4 Complex

    James Sampietro;Caroline L. Dahlberg;Uhn Soo Cho;Thomas R. Hinds

  • at 2,5 A Resolution Reveals Structural Basis for Pax Developmental Mutations

    Wenqing Xu;Mark A. Rould;Susie Jun;Claude Desplan

Frequent Co-Authors

David Kimelman
David Kimelman University of Washington
Zihe Rao
Zihe Rao Tsinghua University
Goutham Narla
Goutham Narla University of Michigan–Ann Arbor
Rachel E. Klevit
Rachel E. Klevit University of Washington
David L. Brautigan
David L. Brautigan University of Virginia
Jukka Westermarck
Jukka Westermarck Åbo Akademi University
H. Eric Xu
H. Eric Xu Chinese Academy of Sciences
Michael J. Eck
Michael J. Eck Harvard University
Karsten Melcher
Karsten Melcher Van Andel Institute

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