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Molecular Biology

D-Index
80
Citations
23596
World Ranking
998
National Ranking
527

Overview

David Kimelman is a researcher affiliated with the University of Washington in the United States. Their work primarily focuses on biochemistry, genetics, and molecular biology, with substantial contributions in molecular biology and cell biology. Their research extends into specialized areas including aging, pulmonary and respiratory medicine, and cancer research.

The scientist's research covers several main topics, highlighting an emphasis on single-cell and spatial transcriptomics, congenital heart defects, and zebrafish biomedical research applications. Other key topics include developmental biology and gene regulation, RNA modifications in cancer, pluripotent stem cells, and genetics related to aging and longevity in model organisms.

David Kimelman has published extensively, with notable papers including:

  • A single-cell time-lapse of mouse prenatal development from gastrula to birth (2024, Nature)
  • Embryo-scale reverse genetics at single-cell resolution (2023, Nature)
  • Proteostasis governs differential temperature sensitivity across embryonic cell types (2023, Cell)
  • Hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development (2020, Development)
  • Deep molecular, cellular and temporal phenotyping of developmental perturbations at whole organism scale (2022, bioRxiv [Cold Spring Harbor Laboratory])

The frequent co-authors collaborating with David Kimelman include:

  • Cole Trapnell
  • Jay Shendure
  • Madeleine Duran
  • Sanjay Srivatsan
  • Lauren M. Saunders

The venues where their research is regularly published reflect their active presence in influential scientific journals and preprint servers. These venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Development
  • Nature
  • Cell
  • SSRN Electronic Journal

Best Publications

  • The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.

    Cynthia Yost;Monica Torres;Jeffrey R. Miller;Eugene Huang

  • Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo

    David Kimelman;Marc Kirschner

  • Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.

    Junhao Mao;Junhao Mao;Jiyong Wang;Bo Liu;Bo Liu;Weijun Pan

  • A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus.

    Mark Brannon;Miranda Gomperts;Lauro Sumoy;Randall T. Moon

  • beta-catenin destruction complex: insights and questions from a structural perspective.

    D Kimelman;W Xu

  • Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway

    Carolyn A. Larabell;Monica Torres;Brian A. Rowning;Cynthia Yost

  • Role of Glycogen Synthase Kinase-3β in Neuronal Apoptosis Induced by Trophic Withdrawal

    Michal Hetman;Jane E. Cavanaugh;David Kimelman;Zhengui Xia

  • Crystal Structure of a β-Catenin/Tcf Complex

    Thomas A. Graham;Carole Weaver;Feng Mao;David Kimelman

  • Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1

    Lin Li;Huidong Yuan;Carole D. Weaver;Junhao Mao

  • A homeobox gene essential for zebrafish notochord development

    William S. Talbot;Bill Trevarrow;Bill Trevarrow;Marnie E. Halpern;Marnie E. Halpern;Anna E. Melby

  • Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes

    Kevin J. P. Griffin;Sharon L. Amacher;Charles B. Kimmel;David Kimelman

  • The presence of fibroblast growth factor in the frog egg: its role as a natural mesoderm inducer.

    David Kimelman;Judith A. Abraham;Tapio Haaparanta;Thomas M. Palisi

  • GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis

    Cynthia Yost;Gist H Farr;Sarah B Pierce;Denise M Ferkey

  • From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus

    Randall T. Moon;David Kimelman

  • The events of the midblastula transition in Xenopus are regulated by changes in the cell cycle.

    David Kimelman;Marc Kirschner;Talma Scherson

  • An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes

    David Kimelman;Marc W. Kirschner

  • XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development

    M. Brannon;J.D. Brown;R. Bates;D. Kimelman

  • Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3.

    Sarah B. Pierce;David Kimelman

  • Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex.

    Yi Xing;Wilson K. Clements;David Kimelman;Wenqing Xu

  • Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo.

    Jennifer E. Schmidt;Atsushi Suzuki;Naoto Ueno;David Kimelman

Frequent Co-Authors

Wenqing Xu
Wenqing Xu University of Washington
Randall T. Moon
Randall T. Moon University of Washington
Ethan Bier
Ethan Bier University of California, San Diego
William S. Talbot
William S. Talbot Stanford University
Mont R. Juchau
Mont R. Juchau University of Washington
Charles B. Kimmel
Charles B. Kimmel University of Oregon
Didier Y. R. Stainier
Didier Y. R. Stainier Max Planck Society
Alexander F. Schier
Alexander F. Schier University of Basel
Wolfgang Driever
Wolfgang Driever University of Freiburg
David W. Raible
David W. Raible University of Washington

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