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Medicine

D-Index
79
Citations
23381
World Ranking
17541
National Ranking
8775

Overview

Gene P. Siegal is affiliated with the University of Alabama at Birmingham in the United States. Their research spans major fields including Medicine and Biochemistry, Genetics and Molecular Biology, with a notable focus on oncology and molecular mechanisms underlying cancer.

The scientist has a body of work that includes 67 publications in Medicine and 28 in Biochemistry, Genetics and Molecular Biology. Subfields where they have been active include Oncology, Pulmonary and Respiratory Medicine, Molecular Biology, Cancer Research, and Rheumatology.

Key topics Gene P. Siegal has explored involve:

  • HER2/EGFR in Cancer Research
  • Sarcoma Diagnosis and Treatment
  • Breast Cancer Treatment Studies
  • Cancer Genomics and Diagnostics
  • Oral and Maxillofacial Pathology
  • Cancer Immunotherapy and Biomarkers
  • Bone Tumor Diagnosis and Treatments

Their recent scientific papers demonstrate a focus on breast cancer pathology and receptor dynamics. These include:

  • Receptor conversion in metastatic breast cancer: analysis of 390 cases from a single institution, 2020, Modern Pathology
  • Characterization of estrogen receptor-low-positive breast cancer, 2021, Breast Cancer Research and Treatment
  • Discordance Between Immunohistochemistry and In Situ Hybridization to Detect HER2 Overexpression/Gene Amplification in Breast Cancer in the Modern Age: A Single Institution Experience and Pooled Literature Review Study, 2021, Clinical Breast Cancer
  • Return of Individual Research Results, 2020, American Journal Of Pathology
  • The dynamics of HER2-low expression during breast cancer progression, 2023, Breast Cancer Research and Treatment

Gene P. Siegal frequently publishes in several venues with multiple contributions including:

  • Modern Pathology (6 publications)
  • UNC Libraries (5 publications)
  • Clinical Breast Cancer (4 publications)
  • Laboratory Investigation (4 publications)
  • Breast Cancer Research and Treatment (3 publications)

The scientist regularly collaborates with a set of co-authors, notable among them:

  • Shi Wei (22 co-authored works)
  • Shuko Harada (12 co-authored works)
  • Xiao Huang (8 co-authored works)
  • Brooke B. Bartow (7 co-authored works)
  • Ceren Yalnız (7 co-authored works)

Best Publications

  • Osteosarcoma: The Addition of Muramyl Tripeptide to Chemotherapy Improves Overall Survival—A Report From the Children's Oncology Group

    Paul A. Meyers;Cindy L. Schwartz;Mark D. Krailo;John H. Healey

  • Osteosarcoma: A Randomized, Prospective Trial of the Addition of Ifosfamide and/or Muramyl Tripeptide to Cisplatin, Doxorubicin, and High-Dose Methotrexate

    Paul A. Meyers;Cindy L. Schwartz;Mark Krailo;Eugenie S. Kleinerman

  • Effect of Plasminogen Activator (Urokinase), Plasmin, and Thrombin on Glycoprotein and Collagenous Components of Basement Membrane

    L A Liotta;R H Goldfarb;R Brundage;G P Siegal

  • Loss of basement membrane components by invasive tumors but not by their benign counterparts

    S H Barsky;G P Siegal;F Jannotta;L A Liotta

  • Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate.

    C. K. Goldman;R. L. Kendall;G. Cabrera;L. Soroceanu

  • Osteosarcoma: anatomic and histologic variants.

    Michael J. Klein;Gene P. Siegal

  • Stromal cell–derived factor 1 promotes angiogenesis via a heme oxygenase 1–dependent mechanism

    Jessy Deshane;Sifeng Chen;Sergio Caballero;Anna Grochot-Przeczek

  • Phase II Trial of Trastuzumab in Combination With Cytotoxic Chemotherapy for Treatment of Metastatic Osteosarcoma With Human Epidermal Growth Factor Receptor 2 Overexpression: A Report From the Children's Oncology Group

    David Ebb;Paul Meyers;Holcombe Grier;Mark Bernstein

  • Phase II/III Trial of Etoposide and High-Dose Ifosfamide in Newly Diagnosed Metastatic Osteosarcoma: A Pediatric Oncology Group Trial

    Allen M. Goorin;Michael B. Harris;Mark Bernstein;William Ferguson

  • Loss of Fibroblast Thy-1 Expression Correlates with Lung Fibrogenesis

    James S. Hagood;Priya Prabhakaran;Pallavi Kumbla;Lorena Salazar

  • Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis.

    Yan Y. Sanders;Annie Pardo;Moisés Selman;Gerard J. Nuovo

  • Breast cancer subtypes predispose the site of distant metastases.

    Abha Soni;Zhiyong Ren;Omar Hameed;Omar Hameed;Diptiman Chanda

  • Targeted Gene Delivery to Kaposi's Sarcoma Cells via the Fibroblast Growth Factor Receptor'

    Corey K. Goldman;Buck E. Rogers;Joanne T. Douglas;Barbara A. Sosnowski

  • Mesenchymal stem cells as a vehicle for targeted delivery of CRAds to lung metastases of breast carcinoma.

    Mariam A Stoff-Khalili;Angel A Rivera;J Michael Mathis;N Sanjib Banerjee

  • Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma.

    Hiroshi Sasaki;Hiroshi Nishii;Hiroyuki Takahashi;Akio Tada

  • 1 alpha,25-Dihydroxyvitamin D (calcitriol) inhibits the invasiveness of human prostate cancer cells.

    G G Schwartz;M H Wang;M Zang;R K Singh

  • Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses.

    Anna Kanerva;Minghui Wang;Gerd J. Bauerschmitz;John T. Lam

  • A cancer gene therapy approach utilizing an anti-erbB-2 single-chain antibody-encoding adenovirus (AD21): a phase I trial.

    Ronald D. Alvarez;Mack N. Barnes;Jesus Gomez-Navarro;Minghui Wang

  • Sarcomas of bone complicating osteitis deformans (Paget's disease): fifty years' experience.

    M R Wick;G P Siegal;K K Unni;R A McLeod

  • Immunohistochemistry in the evaluation of neovascularization in tumor xenografts.

    Dezhi Wang;Cecil R Stockard;Louie Harkins;Patricia Lott

Frequent Co-Authors

David T. Curiel
David T. Curiel Washington University in St. Louis
Ronald D. Alvarez
Ronald D. Alvarez Vanderbilt University Medical Center
Akseli Hemminki
Akseli Hemminki University of Helsinki
William E. Grizzle
William E. Grizzle University of Alabama at Birmingham
Selvarangan Ponnazhagan
Selvarangan Ponnazhagan University of Alabama at Birmingham
Lance A. Liotta
Lance A. Liotta George Mason University
Jay M. McDonald
Jay M. McDonald University of Alabama at Birmingham
Victor Krasnykh
Victor Krasnykh The University of Texas MD Anderson Cancer Center
Holcombe E. Grier
Holcombe E. Grier Harvard University
Jaroslaw W. Zmijewski
Jaroslaw W. Zmijewski University of Alabama at Birmingham

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