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Biology and Biochemistry

D-Index
54
Citations
8365
World Ranking
15822
National Ranking
6577

Overview

Selvarangan Ponnazhagan is affiliated with the University of Alabama at Birmingham in the United States. Their research spans several key areas in biochemistry, genetics, molecular biology, medicine, immunology, and microbiology, reflecting a multidisciplinary approach to scientific investigation.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine
  • Immunology and Microbiology

Within these main areas, Ponnazhagan has contributed extensively to specific subfields such as:

  • Molecular Biology
  • Oncology
  • Immunology
  • Genetics
  • Pulmonary and Respiratory Medicine

Their research topics focus primarily on aspects related to cancer and immune response, including:

  • Cancer Immunotherapy and Biomarkers
  • Immune cells in cancer
  • Immunotherapy and Immune Responses
  • Epigenetics and DNA Methylation
  • Extracellular vesicles in disease
  • Virus-based gene therapy research
  • Cancer Cells and Metastasis

Ponnazhagan has published research in a range of scientific journals and venues with a particular concentration in the following:

  • Cancer Research
  • Frontiers in Immunology
  • Molecular Cancer Therapeutics
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Laboratory Investigation

Among their recent papers are:

  • "Revisiting Immunotherapy: A Focus on Prostate Cancer," 2020, Cancer Research
  • "Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages," 2021, Cancer Research
  • "Mechanical strain induces phenotypic changes in breast cancer cells and promotes immunosuppression in the tumor microenvironment," 2020, Laboratory Investigation
  • "Synthetic Biology Design as a Paradigm Shift toward Manufacturing Affordable Adeno-Associated Virus Gene Therapies," 2023, ACS Synthetic Biology
  • "Runx2 Deficiency in Osteoblasts Promotes Myeloma Progression by Altering the Bone Microenvironment at New Bone Sites," 2020, Cancer Research

Ponnazhagan has frequently collaborated with the following fellow researchers:

  • Jessy S. Deshane
  • Kayla F. Goliwas
  • Kenneth P. Hough
  • Joel L. Berry
  • Joo Hyoung Lee

Best Publications

  • Cancer gene therapy using mesenchymal stem cells expressing interferon-β in a mouse prostate cancer lung metastasis model

    Changchun Ren;Sanjay Kumar;Diptiman Chanda;Lisa Kallman

  • Therapeutic Potential of Mesenchymal Stem Cells Producing Interferon-α in a Mouse Melanoma Lung Metastasis Model

    Changchun Ren;Sanjay Kumar;Diptiman Chanda;Jian Chen

  • Pulmonary angiogenesis in a rat model of hepatopulmonary syndrome.

    Junlan Zhang;Bao Luo;Liping Tang;Yongming Wang

  • Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer.

    Anandi Sawant;Jessy Deshane;Joel Jules;Carnella M. Lee

  • Bone homing of mesenchymal stem cells by ectopic α4 integrin expression

    Sanjay Kumar;Selvarangan Ponnazhagan

  • Mesenchymal stem cells expressing osteogenic and angiogenic factors synergistically enhance bone formation in a mouse model of segmental bone defect.

    Sanjay Kumar;Chao Wan;Girish Ramaswamy;Thomas L Clemens

  • Therapeutic potential of genetically modified mesenchymal stem cells

    S Kumar;D Chanda;S Ponnazhagan

  • Lack of site-specific integration of the recombinant adeno-associated virus 2 genomes in human cells.

    Selvarangan Ponnazhagan;Dana Erikson;William G. Kearns;Shang Zhen Zhou

  • Adeno-Associated Virus Type 2-Mediated Gene Transfer: Correlation of Tyrosine Phosphorylation of the Cellular Single-Stranded D Sequence-Binding Protein with Transgene Expression in Human Cells In Vitro and Murine Tissues In Vivo

    Keyun Qing;Benjawan Khuntirat;Cathryn Mah;Dagmar M. Kube

  • Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in diseases of the skeleton.

    Diptiman Chanda;Sanjay Kumar;Selvarangan Ponnazhagan

  • Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression

    Arun Srivastava;Keyun Qing;Xu-Shan Wang;Selvarangan Ponnazhagan

  • Rescue and replication of adeno-associated virus type 2 as well as vector DNA sequences from recombinant plasmids containing deletions in the viral inverted terminal repeats: selective encapsidation of viral genomes in progeny virions.

    Xu-Shan Wang;Selvarangan Ponnazhagan;Andarun Srivastava

  • Depletion of Plasmacytoid Dendritic Cells Inhibits Tumor Growth and Prevents Bone Metastasis of Breast Cancer Cells

    Anandi Sawant;Jonathan A. Hensel;Diptiman Chanda;Brittney A. Harris

  • Conjugate-based targeting of recombinant adeno-associated virus type 2 vectors by using avidin-linked ligands.

    Selvarangan Ponnazhagan;Gandham Mahendra;Sanjay Kumar;John A. Thompson

  • Revisiting Immunotherapy: A Focus on Prostate Cancer

    Ha-Ram Cha;Ha-Ram Cha;Joo Hyoung Lee;Selvarangan Ponnazhagan

  • Adeno-associated virus type 2-mediated transduction in primary human bone marrow-derived CD34+ hematopoietic progenitor cells: donor variation and correlation of transgene expression with cellular differentiation.

    Selvarangan Ponnazhagan;Pinku Mukherjee;Xu Shan Wang;Keyun Qing

  • Adeno-associated virus 2-mediated gene transfer in vivo: organ-tropism and expression of transduced sequences in mice

    Selvarangan Ponnazhagan;Pinku Mukherjee;Mervin C. Yoder;Xu-Shan Wang

  • Mobilization of bone marrow mesenchymal stem cells in vivo augments bone healing in a mouse model of segmental bone defect

    Sanjay Kumar;Selvarangan Ponnazhagan

  • Adeno-Associated Virus Type 2-Mediated Gene Transfer: Role of Epidermal Growth Factor Receptor Protein Tyrosine Kinase in Transgene Expression

    Cathryn Mah;Keyun Qing;Benjawan Khuntirat;Selvarangan Ponnazhagan

  • Evaluation of recombinant adeno-associated virus as a gene transfer vector for the retina

    Calvin A. Grant;Selvarangan Ponnazhagan;Xu-Shan Wang;Arun Srivastava

Frequent Co-Authors

Arun Srivastava
Arun Srivastava University of Florida
Gene P. Siegal
Gene P. Siegal University of Alabama at Birmingham
Mervin C. Yoder
Mervin C. Yoder Indiana University
William E. Grizzle
William E. Grizzle University of Alabama at Birmingham
David T. Curiel
David T. Curiel Washington University in St. Louis
W. Timothy Garvey
W. Timothy Garvey University of Alabama at Birmingham
Eric J. Sorscher
Eric J. Sorscher Emory University
Victor J. Thannickal
Victor J. Thannickal Tulane University
Sudhir Paul
Sudhir Paul Covalent Bioscience
Victor M. Darley-Usmar
Victor M. Darley-Usmar University of Alabama at Birmingham

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