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Christophe Guilhot

Christophe Guilhot

D-Index & Metrics

Biology and Biochemistry

D-Index
46
Citations
9480
World Ranking
18880
National Ranking
880

Overview

Christophe Guilhot is affiliated with Paul Sabatier University in France and has contributed extensively to research in medicine as well as biochemistry, genetics, and molecular biology. Their work spans various subfields including epidemiology, infectious diseases, molecular medicine, molecular biology, and pharmacology. The primary focus of their research addresses topics such as Mycobacterium research and diagnosis, tuberculosis research and epidemiology, antibiotic resistance in bacteria, microbial natural products and biosynthesis, genomics and phylogenetic studies, Pneumocystis jirovecii pneumonia detection and treatment, and advances in cystic fibrosis research.

Guilhot's publication record includes multiple frequent co-authors, highlighting collaborative efforts in their scientific work. These co-authors are Christian Chalut, Wladimir Malaga, Catherine Astarie-Dequeker, Lionel Mourey, and Serge Mazères.

Their research findings have been disseminated across a range of scientific venues. The most frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory), PLoS Pathogens, Scientific Reports, Tuberculosis, and Molecular Microbiology.

Recent papers authored or co-authored by Christophe Guilhot include the following:

  • Mycobacteria-host interactions in human bronchiolar airway organoids (2021, Molecular Microbiology)
  • The Lipid Virulence Factors of Mycobacterium tuberculosis Exert Multilayered Control over Autophagy-Related Pathways in Infected Human Macrophages (2020, Cells)
  • Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors (2020, Frontiers in Cellular and Infection Microbiology)
  • Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids (2023, PLoS Pathogens)
  • Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli (2021, Nature Microbiology)

Best Publications

  • Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature‐tagged transposon mutagenesis

    Luis Reinaldo Camacho;Danielle Ensergueix;Esther Perez;Brigitte Gicquel

  • Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis

    Vladimir Pelicic;Mary Jackson;Jean Marc Reyrat;William R. Jacobs

  • An essential role for phoP in Mycobacterium tuberculosis virulence.

    Esther Pérez;Sofía Samper;Yann Bordas;Christophe Guilhot

  • A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms

    Damien Portevin;Célia de Sousa-D'Auria;Christine Houssin;Christine Grimaldi

  • Analysis of the Phthiocerol Dimycocerosate Locus ofMycobacterium tuberculosis EVIDENCE THAT THIS LIPID IS INVOLVED IN THE CELL WALL PERMEABILITY BARRIER

    Luis R. Camacho;Patricia Constant;Catherine Raynaud;Marie Antoinette Lanéelle

  • Inactivation of the antigen 85C gene profoundly affects the mycolate content and alters the permeability of the Mycobacterium tuberculosis cell envelope.

    Mary Jackson;Catherine Raynaud;Marie‐Antoinette Lanéelle;Christophe Guilhot

  • Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene.

    Patricia Constant;Esther Perez;Wladimir Malaga;Marie-Antoinette Lanéelle

  • Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials.

    Ainhoa Arbues;Ainhoa Arbues;Juan I. Aguilo;Juan I. Aguilo;Jesus Gonzalo-Asensio;Jesus Gonzalo-Asensio;Dessislava Marinova;Dessislava Marinova

  • Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids.

    Catherine Astarie-Dequeker;Laurent Le Guyader;Wladimir Malaga;Fam-Ky Seaphanh

  • Phospholipases C are involved in the virulence of Mycobacterium tuberculosis.

    Catherine Raynaud;Christophe Guilhot;Jean Rauzier;Yann Bordat

  • Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator

    Jesús Gonzalo-Asensio;Wladimir Malaga;Alexandre Pawlik;Catherine Astarie-Dequeker;Catherine Astarie-Dequeker

  • ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis.

    Jacques Augenstreich;Ainhoa Arbues;Roxane Simeone;Evert Haanappel

  • The Acyl-AMP Ligase FadD32 and AccD4-containing Acyl-CoA Carboxylase Are Required for the Synthesis of Mycolic Acids and Essential for Mycobacterial Growth IDENTIFICATION OF THE CARBOXYLATION PRODUCT AND DETERMINATION OF THE ACYL-CoA CARBOXYLASE COMPONENTS

    Damien Portevin;Célia de Sousa-D'Auria;Henri Montrozier;Christine Houssin

  • Persistence and Protective Efficacy of a Mycobacterium tuberculosis Auxotroph Vaccine

    Mary Jackson;Susan W. Phalen;Micheline Lagranderie;Danielle Ensergueix

  • Efficient transposition in mycobacteria: construction of Mycobacterium smegmatis insertional mutant libraries.

    C Guilhot;I Otal;I Van Rompaey;C Martìn

  • The phenolic glycolipid of Mycobacterium tuberculosis differentially modulates the early host cytokine response but does not in itself confer hypervirulence.

    Daniel Sinsimer;Gaelle Huet;Claudia Manca;Liana Tsenova

  • Mycobacterium tuberculosis lineage influences innate immune response and virulence and is associated with distinct cell envelope lipid profiles.

    Nitya Krishnan;Wladimir Malaga;Wladimir Malaga;Patricia Constant;Patricia Constant;Maxine Caws

  • The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis.

    Luis Solans;Jesús Gonzalo-Asensio;Claudia Sala;Andrej Benjak

  • Recent advances in deciphering the contribution of Mycobacterium tuberculosis lipids to pathogenesis.

    Olivier Neyrolles;Olivier Neyrolles;Christophe Guilhot;Christophe Guilhot

  • Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis.

    Virginie Puech;Christophe Guilhot;Esther Perez;Marielle Tropis

Frequent Co-Authors

Brigitte Gicquel
Brigitte Gicquel Institut Pasteur
Mamadou Daffé
Mamadou Daffé Centre national de la recherche scientifique, CNRS
Mary Jackson
Mary Jackson Colorado State University
Carlos Martín
Carlos Martín Instituto de Salud Carlos III
Lionel Mourey
Lionel Mourey Federal University of Toulouse Midi-Pyrénées
Roland Brosch
Roland Brosch Institut Pasteur
Olivier Neyrolles
Olivier Neyrolles Paul Sabatier University
Odile Burlet-Schiltz
Odile Burlet-Schiltz Federal University of Toulouse Midi-Pyrénées
Caroline Demangel
Caroline Demangel Institut Pasteur
Allan J. Hance
Allan J. Hance Université Paris Cité

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