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Roland Brosch

Roland Brosch

D-Index & Metrics

Microbiology

D-Index
89
Citations
40358
World Ranking
706
National Ranking
37

Overview

Roland Brosch is affiliated with the Institut Pasteur in France and has contributed extensively to research in medicine, particularly focusing on infectious diseases and tuberculosis. Their body of work spans multiple subfields including infectious diseases, epidemiology, surgery, immunology, and molecular biology.

The scientist's research concentrates on topics such as tuberculosis research and epidemiology, Mycobacterium research and diagnosis, antibiotic resistance in bacteria, and infectious diseases related to tuberculosis. Other important areas include diagnosis and treatment of tuberculosis, immune responses and vaccinations, as well as genomics and phylogenetic studies.

Frequent collaborators in Roland Brosch's research include Wafa Frigui, Fadel Sayes, Alexandre Pawlik, Mickael Orgeur, and Jan Madacki. Their work has been published in several prominent venues, with multiple contributions to bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Proceedings of the National Academy of Sciences, EBioMedicine, and Frontiers in Cellular and Infection Microbiology.

Selected recent papers by Roland Brosch include:

  • The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection, 2020, eLife
  • TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages, 2020, Nature Communications
  • Evolution and emergence of Mycobacterium tuberculosis, 2024, FEMS Microbiology Reviews
  • The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence, 2022, Proceedings of the National Academy of Sciences
  • Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro-American genetic background confers optimal vaccine potential, 2020, EBioMedicine

Best Publications

  • Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

    S. T. Cole;R. Brosch;J. Parkhill;T. Garnier

  • A new evolutionary scenario for the Mycobacterium tuberculosis complex

    R. Brosch;S. V. Gordon;M. Marmiesse;P. Brodin

  • Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti.

    Alexander S. Pym;Priscille Brodin;Roland Brosch;Michel Huerre

  • Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis.

    M. Cristina Gutierrez;Sylvain Brisse;Roland Brosch;Michel Fabre

  • Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

    Vadim Makarov;Giulia Manina;Katarina Mikusova;Ute Möllmann

  • Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis.

    Alexander S. Pym;Alexander S. Pym;Priscille Brodin;Laleh Majlessi;Roland Brosch

  • Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays.

    Stephen V. Gordon;Roland Brosch;Alain Billault;Thierry Garnier

  • Genome plasticity of BCG and impact on vaccine efficacy.

    Roland Brosch;Stephen V. Gordon;Thierry Garnier;Karin Eiglmeier

  • Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

    Timothy P. Stinear;Torsten Seemann;Paul F. Harrison;Grant A. Jenkin

  • Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death.

    Roxane Simeone;Alexandre Bobard;Juliane Lippmann;Wilbert Bitter

  • ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria

    Diane Houben;Caroline Demangel;Jakko Van Ingen;Jorge Perez

  • Non Mycobacterial Virulence Genes in the Genome of the Emerging Pathogen Mycobacterium abscessus

    Fabienne Ripoll;Sophie Pasek;Chantal Schenowitz;Carole Dossat

  • Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.

    Timothy Paul Stinear;Armand Mve-Obiang;Pamela L C Small;Wafa Frigui

  • ESX secretion systems: mycobacterial evolution to counter host immunity

    Matthias I. Gröschel;Fadel Sayes;Roxane Simeone;Laleh Majlessi

  • ESAT-6 proteins: protective antigens and virulence factors?

    Priscille Brodin;Ida Rosenkrands;Peter Andersen;Stewart T. Cole

  • Dissection of ESAT-6 System 1 of Mycobacterium tuberculosis and Impact on Immunogenicity and Virulence

    Priscille Brodin;Laleh Majlessi;Laurent Marsollier;Marien I. de Jonge

  • ESAT-6 from Mycobacterium tuberculosis Dissociates from Its Putative Chaperone CFP-10 under Acidic Conditions and Exhibits Membrane-Lysing Activity

    Marien I. de Jonge;Gérard Pehau-Arnaudet;Marjan M. Fretz;Felix Romain

  • High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors.

    Thierry Christophe;Mary Jackson;Hee Kyoung Jeon;Denis Fenistein

  • Analysis of the proteome of Mycobacterium tuberculosis in silico.

    F. Tekaia;S.V. Gordon;T. Garnier;R. Brosch

  • Rapid and Simple Approach for Identification of Mycobacterium tuberculosis Complex Isolates by PCR-Based Genomic Deletion Analysis

    Linda M. Parsons;Linda M. Parsons;Roland Brosch;Stewart T. Cole;Ákos Somoskövi;Ákos Somoskövi

Frequent Co-Authors

Stewart T. Cole
Stewart T. Cole Institut Pasteur
Priscille Brodin
Priscille Brodin University of Lille
Stephen V. Gordon
Stephen V. Gordon University College Dublin
Carmen Buchrieser
Carmen Buchrieser Institut Pasteur
Jean-Louis Herrmann
Jean-Louis Herrmann Versailles Saint-Quentin-en-Yvelines University
Timothy P. Stinear
Timothy P. Stinear University of Melbourne
Wilbert Bitter
Wilbert Bitter Vrije Universiteit Amsterdam
Laurent Kremer
Laurent Kremer Institut de Recherche en Infectiologie de Montpellier
Christiane Bouchier
Christiane Bouchier Institut Pasteur

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