World's Best Scientists 2026 revealed!
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Best Female Scientists
2025

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Best Female Scientists

D-Index
108
Citations
55950
World Ranking
962
National Ranking
587

Immunology

D-Index
115
Citations
60554
World Ranking
391
National Ranking
241

Medicine

D-Index
115
Citations
60920
World Ranking
4469
National Ranking
2433

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award
  • 2019 - Member of the National Academy of Medicine (NAM)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Elizabeth M. Jaffee is affiliated with Johns Hopkins University in the United States. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology, with substantial contributions in oncology and immunology. Their work addresses the mechanisms and treatments in cancer, particularly pancreatic and hepatic oncology.

Jaffee has published extensively across multiple fields, emphasizing cancer immunotherapy, biomarkers, genomics, and diagnostics. Their research intersects with molecular biology techniques and immune system interactions within cancerous environments.

Frequent co-authors include Elana J. Fertig, Won Jin Ho, Mark Yarchoan, Luciane T. Kagohara, and Robert A. Anders. Their collaboration reflects an interdisciplinary approach spanning oncology and immunology.

Jaffee's recent notable papers include the following:

  • The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities (2020, Nature Reviews Clinical Oncology)
  • Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment (2022, Gastroenterology)
  • Neoadjuvant cabozantinib and nivolumab convert locally advanced hepatocellular carcinoma into resectable disease with enhanced antitumor immunity (2021, Nature Cancer)
  • Current and emerging therapies for patients with advanced pancreatic ductal adenocarcinoma: a bright future (2020, The Lancet Oncology)
  • Priority COVID-19 Vaccination for Patients with Cancer while Vaccine Supply Is Limited (2020, Cancer Discovery)

Their publications appear frequently in respected venues, including Cancer Research, Journal of Clinical Oncology, bioRxiv (Cold Spring Harbor Laboratory), Clinical Cancer Research, and Regular and Young Investigator Award Abstracts.

Key research topics developed by Jaffee encompass:

  • Cancer Immunotherapy and Biomarkers
  • Pancreatic and Hepatic Oncology Research
  • Cancer Genomics and Diagnostics
  • Immunotherapy and Immune Responses
  • Single-cell and spatial transcriptomics
  • Immune cells in cancer
  • Cancer Cells and Metastasis

Subfields of study related to their work include oncology, immunology, molecular biology, cancer research, and pulmonary and respiratory medicine.

Jaffee has been recognized by professional organizations with awards such as being named a Member of the National Academy of Medicine in 2019 and membership in the Association of American Physicians.

Best Publications

  • Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

    Siân Jones;Xiaosong Zhang;D. Williams Parsons;D. Williams Parsons;Jimmy Cheng Ho Lin

  • Vaccination with Irradiated Tumor Cells Engineered to Secrete Murine Granulocyte-Macrophage Colony-Stimulating Factor Stimulates Potent, Specific, and Long-Lasting Anti-Tumor Immunity

    Glenn Dranoff;Elizabeth Jaffee;Audrey Lazenby;Paul Golumbek

  • Tumor Mutational Burden and Response Rate to PD-1 Inhibition

    Mark Yarchoan;Alexander Hopkins;Elizabeth M. Jaffee

  • Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic

    T.A. Chan;M. Yarchoan;E. Jaffee;C. Swanton

  • Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

    Ela Elyada;Ela Elyada;Mohan Bolisetty;Pasquale Laise;William F. Flynn

  • Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance.

    Francesco M. Marincola;Elizabeth M. Jaffee;Daniel J. Hicklin;Soldano Ferrone

  • Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens

    Alex Y. C. Huang;Paul Golumbek;Mojgan Ahmadzadeh;Elizabeth Jaffee

  • The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

    Won Jin Ho;Elizabeth M. Jaffee;Lei Zheng

  • Targeting neoantigens to augment antitumour immunity

    Mark Yarchoan;Burles A. Johnson;Eric R. Lutz;Daniel A. Laheru

  • Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

    Siân Jones;Siân Jones;Ralph H. Hruban;Mihoko Kamiyama;Michael Borges

  • Mechanisms of immune evasion by tumors.

    Charles G. Drake;Elizabeth Jaffee;Drew M. Pardoll

  • Mesothelin Is Overexpressed in the Vast Majority of Ductal Adenocarcinomas of the Pancreas: Identification of a New Pancreatic Cancer Marker by Serial Analysis of Gene Expression (SAGE)

    Pedram Argani;Christine Iacobuzio-Donahue;Byungwoo Ryu;Christophe Rosty

  • Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice.

    Jean Pascal H. Machiels;R. Todd Todd Reilly;Leisha A. Emens;Anne M. Ercolini

  • Novel Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Tumor Vaccine for Pancreatic Cancer: A Phase I Trial of Safety and Immune Activation

    Elizabeth M. Jaffee;Ralph H. Hruban;Barbara Biedrzycki;Daniel Laheru

  • Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer

    Dung T. Le;Andrea Wang-Gillam;Vincent Picozzi;Tim F. Greten

  • Compromised HOXA5 function can limit p53 expression in human breast tumours

    Venu Raman;Shelby A. Martensen;David Reisman;Ella Evron

  • Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer.

    Dung T. Le;Eric Lutz;Jennifer N. Uram;Elizabeth A. Sugar

  • Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays.

    Christine A. Iacobuzio-Donahue;Anirban Maitra;Mari Olsen;Anson W. Lowe

  • Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis

    Takahiro Tsujikawa;Sushil Kumar;Rohan N. Borkar;Vahid Azimi

  • Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation

    Eric R. Lutz;Annie A. Wu;Elaine Bigelow;Rajni Sharma

  • Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by Ex Vivo Granulocyte-Macrophage Colony-Stimulating Factor Gene Transfer

    J.W. Simons;E.M. Jaffee;C.E. Weber;H.J. Levitsky

Frequent Co-Authors

Ralph H. Hruban
Ralph H. Hruban Johns Hopkins University School of Medicine
Robert A. Anders
Robert A. Anders Johns Hopkins University School of Medicine
Christopher L. Wolfgang
Christopher L. Wolfgang New York University
Drew M. Pardoll
Drew M. Pardoll Johns Hopkins University School of Medicine
Charles J. Yeo
Charles J. Yeo Thomas Jefferson University
Thomas W. Dubensky
Thomas W. Dubensky Tempest Therapeutics
Hyam I. Levitsky
Hyam I. Levitsky Johns Hopkins University
Anirban Maitra
Anirban Maitra The University of Texas MD Anderson Cancer Center
Matthew J. Weiss
Matthew J. Weiss Johns Hopkins University School of Medicine
Joseph M. Herman
Joseph M. Herman National Cancer Institute

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