World's Best Scientists 2026 revealed!
Thomas W. Dubensky

Thomas W. Dubensky

D-Index & Metrics

Microbiology

D-Index
60
Citations
14419
World Ranking
3103
National Ranking
1226

Overview

Thomas W. Dubensky is affiliated with Tempest Therapeutics in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a focus on pharmacology, cancer research, genetics, immunology, and oncology.

The scientist has contributed extensively to topics such as inflammatory mediators and NSAID effects, estrogen and related hormone effects, interferon and immune responses, cytokine signaling pathways and interactions, eicosanoids and hypertension pharmacology, as well as cancer metabolism related to hypoxia and lipids.

Recent publications highlight active involvement in clinical trials and cancer immunotherapy, including:

  • Phase I Dose-Escalation Trial of MIW815 (ADU-S100), an Intratumoral STING Agonist, in Patients with Advanced/Metastatic Solid Tumors or Lymphomas (2021, Clinical Cancer Research)
  • Dual Blockade of EP2 and EP4 Signaling is Required for Optimal Immune Activation and Antitumor Activity Against Prostaglandin-Expressing Tumors (2023, Cancer Research Communications)
  • First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors (2024, Cancer Research Communications)
  • A phase 1 study of TPST-1495 as a single agent and in combination with pembrolizumab in patients with advanced solid tumors. (2023, Journal of Clinical Oncology)
  • A phase 1 study of TPST-1120 as a single agent and in combination with nivolumab in subjects with advanced solid tumors. (2022, Journal of Clinical Oncology)

Frequent coauthorship collaborations include researchers such as Sam H. Whiting, Peppi Prasit, Brian J. Francica, Anja Holtz, and Nathan Standifer. These collaborations indicate a sustained engagement with a network of scientists working on similar or complementary research topics.

Thomas W. Dubensky has published repeatedly in prominent venues, with notable frequent publication outlets including:

  • Cancer Research
  • Regular and Young Investigator Award Abstracts
  • Journal of Clinical Oncology
  • Clinical Cancer Research
  • Cancer Research Communications

The profile of research undertaken reveals a multidisciplinary approach with an emphasis on the molecular and immunological mechanisms involved in cancer therapy and pharmacology, aligning with ongoing advancements in targeted clinical interventions and immunotherapies.

Best Publications

  • Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

    Leticia Corrales;Laura Hix Glickman;Sarah M. McWhirter;David B. Kanne

  • STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

    Juan Fu;David B. Kanne;Meredith Leong;Laura Hix Glickman

  • Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer

    Dung T. Le;Andrea Wang-Gillam;Vincent Picozzi;Tim F. Greten

  • Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity.

    Camie W. Chan;Emily Crafton;Hong Ni Fan;James Flook

  • The host STING pathway at the interface of cancer and immunity

    Leticia Corrales;Sarah M. McWhirter;Thomas W. Dubensky;Thomas F. Gajewski

  • Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

    Kelsey E. Sivick;Anthony L. Desbien;Laura Hix Glickman;Gabrielle L. Reiner

  • Listeria-based cancer vaccines that segregate immunogenicity from toxicity

    Dirk G. Brockstedt;Martin A. Giedlin;Meredith L. Leong;Keith S. Bahjat

  • Eukaryotic layered vector initiation systems

    Thomas W. Dubensky;John M. Polo;Carlos E. Ibanez;Stephen M. W. Chang

  • Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways

    Wolfgang W. Leitner;Leroy N. Hwang;Michael J. deVeer;Aimin Zhou

  • A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: phase I studies of safety and immune induction.

    Dung T. Le;Dirk G. Brockstedt;Ran Nir-Paz;Johannes Hampl

  • Adjuvants for cancer vaccines.

    Thomas W. Dubensky;Steven G. Reed

  • An alphavirus replicon particle chimera derived from venezuelan equine encephalitis and sindbis viruses is a potent gene-based vaccine delivery vector.

    Silvia Perri;Catherine E. Greer;Kent Thudium;Barbara Doe

  • DNA Immunization against Herpes Simplex Virus: Enhanced Efficacy Using a Sindbis Virus-Based Vector

    Mangala J. Hariharan;David A. Driver;Kay Townsend;Duane Brumm

  • VSV-G pseudotyped lentiviral vector particles produced in human cells are inactivated by human serum.

    Nicholas J. DePolo;Joyce D. Reed;Philip L. Sheridan;Kay Townsend

  • Sindbis virus DNA-based expression vectors: utility for in vitro and in vivo gene transfer.

    T. W. Dubensky;D. A. Driver;J. M. Polo;B. A. Belli

  • Recombinant alphavirus vectors

    Thomas W. Jr. Del Mar Dubensky;Carlos E. San Diego Ibanez;Stephen M.W. San Diego Chang;Douglas J. Leucadia Jolly

  • Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors

    Jason R. Baird;David Friedman;Benjamin Cottam;Thomas W. Dubensky

  • Enhancement of tumor-specific immune response with plasmid DNA replicon vectors.

    Wolfgang W. Leitner;Han Ying;David A. Driver;Thomas W. Dubensky

  • Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells

    Monica V. Goldberg;Charles H. Maris;Edward L. Hipkiss;Andrew S. Flies

  • Feline immunodeficiency virus vectors persistently transduce nondividing airway epithelia and correct the cystic fibrosis defect

    Guoshun Wang;Vladimir Slepushkin;Joseph Zabner;Shaf Keshavjee

Frequent Co-Authors

Elizabeth M. Jaffee
Elizabeth M. Jaffee Johns Hopkins University
Daniel A. Portnoy
Daniel A. Portnoy University of California, Berkeley
Russell E. Vance
Russell E. Vance University of California, Berkeley
Michael A. Morse
Michael A. Morse Duke University
Herbert J. Zeh
Herbert J. Zeh The University of Texas Southwestern Medical Center
Charles G. Drake
Charles G. Drake Columbia University
Thomas F. Gajewski
Thomas F. Gajewski University of Chicago
Drew M. Pardoll
Drew M. Pardoll Johns Hopkins University School of Medicine
Nina Bhardwaj
Nina Bhardwaj Icahn School of Medicine at Mount Sinai
Michael J. Gough
Michael J. Gough Providence Portland Medical Center

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring related online degrees can open diverse career pathways for those interested in the health sciences. For students wanting to combine microbiology knowledge with healthcare data management, pursuing a cahiim accredited him degree online is a strategic choice that ensures quality education aligned with industry standards.

For quicker entry into health administration roles, earning an online medical billing and coding certificate fast can be ideal. This certification opens doors to essential billing roles that support the healthcare system.

Additionally, students interested in clinical or specialized health professions can investigate what medical degrees can i get online. This resource offers insight into reputable programs available virtually, accommodating various career goals.

Finally, if public health appeals to you, considering the fastest and easiest online mph programs may provide a pathway to advance in epidemiology or health policy, complementing your microbiology background.

Best Scientists Citing Thomas W. Dubensky

Trending Scientists