World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
112
Citations
86820
World Ranking
442
National Ranking
271

Medicine

D-Index
112
Citations
86821
World Ranking
5039
National Ranking
2730

Overview

Charles G. Drake is affiliated with Columbia University in the United States and has contributed extensively to the fields of medicine and immunology. Their research encompasses oncology, pulmonary and respiratory medicine, immunology, molecular biology, and surgery, with a significant focus on cancer and immune-related topics.

The scientist's main areas of study include:

  • Medicine
  • Immunology and Microbiology

Within these broader disciplines, their subfields of expertise are:

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Immunology
  • Molecular Biology
  • Surgery

Drake's research topics concentrate on cancer and immunotherapy, specifically:

  • Cancer Immunotherapy and Biomarkers
  • Prostate Cancer Treatment and Research
  • Immunotherapy and Immune Responses
  • Renal cell carcinoma treatment
  • Immune cells in cancer
  • Bladder and Urothelial Cancer Treatments
  • CAR-T cell therapy research

The scientist has published in several frequent venues, indicating a consistent presence in prominent journals:

  • Journal of Clinical Oncology
  • Cancer Research
  • The Prostate
  • Clinical Cancer Research
  • European Urology

Noteworthy recent papers authored or co-authored by Drake include:

  • Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019 (2020, European Urology)
  • Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages (2021, Cell)
  • Peptide-TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens (2020, Nature Biotechnology)
  • Defining tumor resistance to PD-1 pathway blockade: recommendations from the first meeting of the SITC Immunotherapy Resistance Taskforce (2020, Journal for ImmunoTherapy of Cancer)
  • Prostate carcinogenesis: inflammatory storms (2020, Nature reviews. Cancer)

The scientist maintains collaborative relationships with several frequent co-authors including:

  • Aleksandar Obradović
  • Andrea Califano
  • Matthew G. Chaimowitz
  • Matthew C. Dallos
  • Angelo M. De Marzo

Drake's publication record reflects a sustained focus on cancer immunotherapy, prostate cancer, and immune-based treatment strategies, contributing both to clinical and molecular understandings of cancer biology. Their work spans fundamental studies of tumor microenvironments and immune responses to translational research aimed at improving therapeutic interventions.

Best Publications

  • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.

    Suzanne L. Topalian;F. Stephen Hodi;Julie R. Brahmer;Scott N. Gettinger

  • Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

    Julie R. Brahmer;Scott S. Tykodi;Scott S. Tykodi;Laura Q.M. Chow;Wen Jen Hwu

  • Immune checkpoint blockade: a common denominator approach to cancer therapy

    Suzanne L. Topalian;Charles G. Drake;Drew M. Pardoll

  • Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

    Julie R. Brahmer;Charles G. Drake;Ira Wollner;John D. Powderly

  • A draft map of the human proteome

    Min Sik Kim;Sneha M. Pinto;Derese Getnet;Raja Sekhar Nirujogi

  • Inflammation in prostate carcinogenesis

    Angelo M. De Marzo;Angelo M. De Marzo;Elizabeth A. Platz;Siobhan Sutcliffe;Jianfeng Xu

  • Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial

    Eugene D. Kwon;Charles G. Drake;Howard I. Scher;Karim Fizazi

  • Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

    Seng Ryong Woo;Meghan E Turnis;Monica V Goldberg;Jaishree Bankoti

  • Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity.

    Suzanne L Topalian;Charles G Drake;Drew M Pardoll

  • Role of LAG-3 in regulatory T cells.

    Ching Tai Huang;Creg J. Workman;Dallas Flies;Xiaoyu Pan

  • Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma

    Diana Miao;Diana Miao;Claire A. Margolis;Claire A. Margolis;Wenhua Gao;Martin H. Voss;Martin H. Voss

  • LAG3 (CD223) as a cancer immunotherapy target.

    Lawrence P. Andrews;Ariel E. Marciscano;Charles G. Drake;Dario A. A. Vignali

  • Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas.

    Jing Zeng;Alfred P. See;Jillian Phallen;Christopher M. Jackson

  • Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy

    Andrew B Sharabi;Andrew B Sharabi;Michael Lim;Michael Lim;Theodore L DeWeese;Theodore L DeWeese;Charles G Drake;Charles G Drake

  • Randomized, Double-Blind, Phase III Trial of Ipilimumab Versus Placebo in Asymptomatic or Minimally Symptomatic Patients With Metastatic Chemotherapy-Naive Castration-Resistant Prostate Cancer

    Tomasz M. Beer;Eugene D. Kwon;Charles G. Drake;Karim Fizazi

  • Mechanisms of immune evasion by tumors.

    Charles G. Drake;Elizabeth Jaffee;Drew M. Pardoll

  • Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma

    Sofia Lyford-Pike;Shiwen Peng;Geoffrey D. Young;Janis M. Taube

  • Cutting Edge: An In Vivo Requirement for STAT3 Signaling in TH17 Development and TH17-Dependent Autoimmunity

    Timothy J. Harris;Joseph F. Grosso;Hung Rong Yen;Hong Xin

  • Mechanisms of Resistance to Immune Checkpoint Blockade: Why Does Checkpoint Inhibitor Immunotherapy Not Work for All Patients?

    Charlene M Fares;Eliezer M Van Allen;Charles G Drake;James P Allison

  • Durable Cancer Regression Off-Treatment and Effective Reinduction Therapy with an Anti-PD-1 Antibody

    Evan J. Lipson;William H. Sharfman;Charles G. Drake;Ira Wollner

  • Prostate cancer

    Unknown

Frequent Co-Authors

Emmanuel S. Antonarakis
Emmanuel S. Antonarakis University of Minnesota
Angelo M. De Marzo
Angelo M. De Marzo Johns Hopkins University School of Medicine
Drew M. Pardoll
Drew M. Pardoll Johns Hopkins University School of Medicine
George J. Netto
George J. Netto University of Alabama at Birmingham
Elizabeth A. Platz
Elizabeth A. Platz Johns Hopkins University
Janis M. Taube
Janis M. Taube Johns Hopkins University
Phuoc T. Tran
Phuoc T. Tran Johns Hopkins University School of Medicine
Tullia C. Bruno
Tullia C. Bruno University of Pittsburgh
Toni K. Choueiri
Toni K. Choueiri Harvard University
Michael A. Carducci
Michael A. Carducci Johns Hopkins University

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