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Immunology

D-Index
50
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12349
World Ranking
4206
National Ranking
1920

Overview

Tullia C. Bruno is a researcher affiliated with the University of Pittsburgh in the United States. Their work primarily focuses on the fields of Medicine and Immunology and Microbiology, with a strong emphasis on oncology and immune-related studies within cancer research.

The scientist's main subfields of study include:

  • Oncology
  • Immunology
  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

The topics most frequently addressed in their research involve:

  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Immune cells in cancer
  • T-cell and B-cell Immunology
  • Sarcoma Diagnosis and Treatment

Some of Bruno's notable recent papers include:

  • "Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer," 2020, published in Immunity
  • "Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment," 2023, published in Cell
  • "B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma," 2021, published in Nature Communications
  • "Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing," 2021, published in Nature Communications
  • "Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer," 2021, published in Immunity

Bruno has frequently collaborated with several co-authors, most notably:

  • Dario A.A. Vignali
  • Anthony R. Cillo
  • Sheryl Kunning
  • Robert L. Ferris
  • Riyue Bao

Their research has been published extensively in venues such as:

  • Regular and Young Investigator Award Abstracts
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Journal of Clinical Oncology
  • Journal for ImmunoTherapy of Cancer

Best Publications

  • Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma

    Sofia Lyford-Pike;Shiwen Peng;Geoffrey D. Young;Janis M. Taube

  • LAG-3 regulates CD8 + T cell accumulation and effector function in murine self- and tumor-tolerance systems

    Joseph F. Grosso;Cristin C. Kelleher;Timothy J. Harris;Charles H. Maris

  • Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer

    Anthony R. Cillo;Cornelius H.L. Kürten;Cornelius H.L. Kürten;Tracy Tabib;Zengbiao Qi

  • Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity

    Abigail E. Overacre-Delgoffe;Abigail E. Overacre-Delgoffe;Maria Chikina;Rebekah E. Dadey;Hiroshi Yano

  • Phenotypic Analysis of Prostate-Infiltrating Lymphocytes Reveals TH17 and Treg Skewing

    Karen Sandell Sfanos;Tullia C. Bruno;Charles H. Maris;Lauren Xu

  • STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients

    David Vasquez-Dunddel;Fan Pan;Qi Zeng;Mikhail Gorbounov

  • Adaptive plasticity of IL-10 + and IL-35 + T reg cells cooperatively promotes tumor T cell exhaustion

    Deepali V Sawant;Deepali V Sawant;Hiroshi Yano;Maria Chikina;Qianxia Zhang;Qianxia Zhang

  • Lymphocyte-activation gene 3 (LAG3): The next immune checkpoint receptor

    Elisa Ruffo;Richard C. Wu;Tullia C. Bruno;Creg J. Workman

  • Human prostate-infiltrating CD8+ T lymphocytes are oligoclonal and PD-1+.

    Karen S. Sfanos;Tullia C. Bruno;Alan K. Meeker;Alan K. Meeker;Angelo M. De Marzo;Angelo M. De Marzo

  • B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

    Ayana T. Ruffin;Anthony R. Cillo;Tracy Tabib;Angen Liu

  • Antigen-presenting intratumoral B cells affect CD4+ TIL phenotypes in non-small cell lung cancer patients

    Tullia C. Bruno;Peggy J. Ebner;Brandon L. Moore;Olivia G. Squalls

  • Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells

    Joseph F. Grosso;Monica V. Goldberg;Derese Getnet;Tullia C. Bruno

  • A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

    Derese Getnet;Joseph F. Grosso;Monica V. Goldberg;Timothy J. Harris

  • Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer.

    Abigail E. Overacre-Delgoffe;Hannah J. Bumgarner;Anthony R. Cillo;Ansen H.P. Burr

  • Tc17 CD8 T cells: functional plasticity and subset diversity.

    Hung Rong Yen;Timothy J. Harris;Satoshi Wada;Joseph F. Grosso

  • Therapeutic targeting of regulatory T cells in cancer

    Unknown

  • LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

    Unknown

  • The Great Immune Escape: Understanding the Divergent Immune Response in Breast Cancer Subtypes

    Unknown

  • Phenotypic and Functional Properties of Helios+ Regulatory T Cells

    Daniel J. Zabransky;Christopher J. Nirschl;Nicholas M. Durham;Ben V. Park

  • Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes

    A. Nicole Desch;A. Nicole Desch;A. Nicole Desch;Sophie L. Gibbings;Rajni Goyal;Raivo Kolde;Raivo Kolde

  • COVID-19 versus Non-COVID-19 Acute Respiratory Distress Syndrome: Comparison of Demographics, Physiologic Parameters, Inflammatory Biomarkers, and Clinical Outcomes.

    William Bain;William Bain;Haopu Yang;Haopu Yang;Faraaz Ali Shah;Faraaz Ali Shah;Tomeka Suber

  • Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study.

    Matthew K Hensley;William G Bain;William G Bain;Jana Jacobs;Sham Nambulli

  • Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity.

    Paula Araya;Paula Araya;Katherine A. Waugh;Kelly D. Sullivan;Nicolás G. Núñez

  • A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma

    Lisa I Greene;Tullia C Bruno;Jessica L Christenson;Angelo D'Alessandro

Frequent Co-Authors

Dario A. A. Vignali
Dario A. A. Vignali University of Pittsburgh
Charles G. Drake
Charles G. Drake Columbia University
Drew M. Pardoll
Drew M. Pardoll Johns Hopkins University School of Medicine
Robert L. Ferris
Robert L. Ferris University of Pittsburgh
Robert Lafyatis
Robert Lafyatis University of Pittsburgh
Creg J. Workman
Creg J. Workman University of Pittsburgh
Martin D. McCarter
Martin D. McCarter University of Colorado Anschutz Medical Campus
Anuradha Ray
Anuradha Ray University of Pittsburgh
Janet S. Lee
Janet S. Lee University of Pittsburgh
Prabir Ray
Prabir Ray University of Pittsburgh

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