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Immunology

D-Index
56
Citations
28539
World Ranking
3660
National Ranking
1689

Overview

Creg J. Workman is affiliated with the University of Pittsburgh in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, focusing on subfields including Immunology, Oncology, Neurology, Molecular Biology, and Infectious Diseases.

The scientist's research topics cover several areas, detailed as follows:

  • Cancer Immunotherapy and Biomarkers
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • COVID-19 Clinical Research Studies
  • Neuroblastoma Research and Treatments

Workman has a substantial record of publication in multiple venues with recurring contributions to the following journals:

  • The Journal of Immunology
  • Regular and Young Investigator Award Abstracts
  • Nature Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell

The scientist's recent notable papers include:

  • "Interferon-γ: teammate or opponent in the tumour microenvironment?" (2021), published in Nature Reviews. Immunology
  • "LAG-3 as the third checkpoint inhibitor" (2023), published in Nature Immunology
  • "Therapeutic targeting of regulatory T cells in cancer" (2022), published in Trends in Cancer
  • "LAG3 associates with TCR-CD3 complexes and suppresses signaling by driving co-receptor-Lck dissociation" (2022), published in Nature Immunology
  • "Regulatory T Cells: Barriers of Immune Infiltration Into the Tumor Microenvironment" (2021), published in Frontiers in Immunology

Frequent collaborators in Workman's research include:

  • Dario A.A. Vignali
  • Anthony R. Cillo
  • Tullia C. Bruno
  • Carly Cardello
  • Lawrence P. Andrews

Best Publications

  • How regulatory T cells work.

    Dario A. A. Vignali;Lauren W. Collison;Creg J. Workman

  • The inhibitory cytokine IL-35 contributes to regulatory T-cell function

    Lauren W. Collison;Creg J. Workman;Timothy T. Kuo;Kelli Boyd

  • Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

    Shawn D Blackburn;Haina Shin;W Nicholas Haining;W Nicholas Haining;Tao Zou

  • Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

    Seng Ryong Woo;Meghan E Turnis;Monica V Goldberg;Jaishree Bankoti

  • Role of LAG-3 in regulatory T cells.

    Ching Tai Huang;Creg J. Workman;Dallas Flies;Xiaoyu Pan

  • Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector.

    Andrea L Szymczak;Andrea L Szymczak;Creg J Workman;Yao Wang;Kate M Vignali

  • IL-35-mediated induction of a potent regulatory T cell population

    Lauren W Collison;Vandana Chaturvedi;Abigail L Henderson;Abigail L Henderson;Paul R Giacomin

  • Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3

    Xiaobo Mao;Michael Tianhao Ou;Senthilkumar S. Karuppagounder;Tae In Kam

  • Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

    Greg M. Delgoffe;Seng-Ryong Woo;Meghan E. Turnis;David M. Gravano

  • Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity

    Abigail E. Overacre-Delgoffe;Abigail E. Overacre-Delgoffe;Maria Chikina;Rebekah E. Dadey;Hiroshi Yano

  • Interferon-γ: teammate or opponent in the tumour microenvironment?

    Angela M Gocher;Creg J Workman;Dario A A Vignali

  • Adaptive plasticity of IL-10 + and IL-35 + T reg cells cooperatively promotes tumor T cell exhaustion

    Deepali V Sawant;Deepali V Sawant;Hiroshi Yano;Maria Chikina;Qianxia Zhang;Qianxia Zhang

  • Cutting Edge: Molecular Analysis of the Negative Regulatory Function of Lymphocyte Activation Gene-3

    Creg J. Workman;Kari J. Dugger;Dario A. A. Vignali

  • The Development and Function of Regulatory T Cells

    Creg J. Workman;Andrea L. Szymczak-Workman;Lauren W. Collison;Meenu R. Pillai

  • Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223).

    Creg J. Workman;Dario A. A. Vignali

  • The CD4‐related molecule, LAG‐3 (CD223), regulates the expansion of activated T cells

    Creg J. Workman;Dario A. A. Vignali

  • Lymphocyte Activation Gene-3 (CD223) Regulates the Size of the Expanding T Cell Population Following Antigen Activation In Vivo

    Creg J. Workman;Linda S. Cauley;In-Jeong Kim;Marcia A. Blackman

  • Lymphocyte-activation gene 3 (LAG3): The next immune checkpoint receptor

    Elisa Ruffo;Richard C. Wu;Tullia C. Bruno;Creg J. Workman

  • Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ

    Chang Liu;Maria Chikina;Rahul Deshpande;Ashley V. Menk

  • Generation of T-cell receptor retrogenic mice

    Jeff Holst;Andrea L Szymczak-Workman;Kate M Vignali;Amanda R Burton

  • Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria

    Tapio Lönnberg;Tapio Lönnberg;Valentine Svensson;Kylie R. James;Daniel Fernandez-Ruiz

  • Metalloproteases regulate T-cell proliferation and effector function via LAG-3

    Nianyu Li;Yao Wang;Karen Forbes;Kate M Vignali

Frequent Co-Authors

Dario A. A. Vignali
Dario A. A. Vignali University of Pittsburgh
Drew M. Pardoll
Drew M. Pardoll Johns Hopkins University School of Medicine
Charles G. Drake
Charles G. Drake Columbia University
Tullia C. Bruno
Tullia C. Bruno University of Pittsburgh
Peter Vogel
Peter Vogel St. Jude Children's Research Hospital
Kelli L. Boyd
Kelli L. Boyd Vanderbilt University Medical Center
David Finkelstein
David Finkelstein St. Jude Children's Research Hospital
Richard J. Smeyne
Richard J. Smeyne Thomas Jefferson University
Roland Tisch
Roland Tisch University of North Carolina at Chapel Hill
Prabir Ray
Prabir Ray University of Pittsburgh

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