World's Best Scientists 2026 revealed!

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Immunology

D-Index
88
Citations
29815
World Ranking
1162
National Ranking
72

Medicine

D-Index
88
Citations
29815
World Ranking
13120
National Ranking
699

Overview

Tim Sparwasser is affiliated with Johannes Gutenberg University of Mainz in Germany. Their research primarily focuses on immunology and microbiology, with a total of 69 publications in these fields, as well as medicine with 34 publications. Sparwasser's work engages deeply with immunology, molecular biology, oncology, pulmonary and respiratory medicine, and epidemiology subfields.

The scientist's research topics cover immune cell function and interaction, T-cell and B-cell immunology, immune response and inflammation, immune cells in cancer, immunotherapy and immune responses, interferon and immune responses, as well as IL-33, ST2, and ILC pathways.

Frequent publication venues for Sparwasser's work include:

  • European Journal of Immunology
  • Cell Reports
  • The Journal of Immunology
  • Journal of Allergy and Clinical Immunology
  • PLoS Pathogens

Notable recent papers authored or co-authored by Sparwasser are:

  • "Regulating T-cell differentiation through the polyamine spermidine" (2020) published in Journal of Allergy and Clinical Immunology
  • "CD4+ T-cell differentiation and function: Unifying glycolysis, fatty acid oxidation, polyamines NAD mitochondria" (2021) published in Journal of Allergy and Clinical Immunology
  • "Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis" (2020) published in Immunity
  • "Notch and TLR signaling coordinate monocyte cell fate and inflammation" (2020) published in eLife
  • "The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis" (2020) published in Cell Reports

Frequent co-authors in Sparwasser's research include:

  • Luciana Berod
  • Luís Almeida
  • Ayesha Dhillon-LaBrooy
  • Luis Eduardo Alves Damasceno
  • Matthias Lochner

Best Publications

  • Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.

    Katharina Lahl;Christoph Loddenkemper;Cathy Drouin;Jennifer Freyer

  • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells

    Tim Sparwasser;Eva Sophie Koch;Ramunas M. Vabulas;Klaus Heeg

  • Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity

    Olaf Gross;Andreas Gewies;Katrin Finger;Martin Schäfer

  • Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria

    Usriansyah Hadis;Benjamin Wahl;Olga Schulz;Matthias Hardtke-Wolenski

  • De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

    Luciana Berod;Christin Friedrich;Amrita Nandan;Jenny Freitag

  • CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation.

    Hans Häcker;Harald Mischak;Thomas Miethke;Susanne Liptay

  • T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

    Naganari Ohkura;Naganari Ohkura;Masahide Hamaguchi;Masahide Hamaguchi;Hiromasa Morikawa;Hiromasa Morikawa;Kyoko Sugimura

  • A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult

    Ziad Al Nabhani;Ziad Al Nabhani;Sophie Dulauroy;Sophie Dulauroy;Rute Marques;Rute Marques;Clara Cousu;Clara Cousu

  • An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation

    Christoph Wilhelm;Keiji Hirota;Benjamin Stieglitz;Jacques Van Snick

  • Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock.

    Tim Sparwasser;Thomas Miethke;Grayson Lipford;Andreas Erdmann

  • Metabolic pathways in T cell activation and lineage differentiation.

    Luís Almeida;Matthias Lochner;Luciana Berod;Tim Sparwasser

  • Bacterial DNA causes septic shock

    Tim Sparwasser;Thomas Miethke;Grayson Lipford;Katrin Borschert

  • Fatty acid metabolism in the regulation of T cell function

    Matthias Lochner;Luciana Berod;Tim Sparwasser

  • Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.

    B-H Yang;S Hagemann;P Mamareli;U Lauer

  • CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis

    John Stagg;Upulie Divisekera;Helene Duret;Tim Sparwasser

  • Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis.

    Roland Klingenberg;Norbert Gerdes;Robert M. Badeau;Anton Gisterå

  • Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature

    Christoph Kleinschnitz;Peter Kraft;Angela Dreykluft;Ina Hagedorn

  • IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

    Marc Pellegrini;Thomas Calzascia;Jesse G. Toe;Simon P. Preston

  • Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation.

    Brenda Raud;Dominic G. Roy;Ajit S. Divakaruni;Tatyana N. Tarasenko

  • PD-L1hi B cells are critical regulators of humoral immunity

    Adnan R. Khan;Emily Hams;Achilleas Floudas;Tim Sparwasser

  • Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells

    Thomas Decker;Folker Schneller;Tim Sparwasser;Theresa Tretter

  • Immunostimulatory DNA: Sequence‐dependent production of potentially harmful or useful cytokines

    Grayson B. Lipford;Tim Sparwasser;Marc Bauer;Stefan Zimmermann

Frequent Co-Authors

Jochen Huehn
Jochen Huehn Helmholtz Centre for Infection Research
Hermann Wagner
Hermann Wagner Technical University of Munich
Grayson B. Lipford
Grayson B. Lipford Janus Biotherapeutics (United States)
Shimon Sakaguchi
Shimon Sakaguchi Osaka University
Anja A. Kühl
Anja A. Kühl Humboldt-Universität zu Berlin
Christoph Loddenkemper
Christoph Loddenkemper Charité - University Medicine Berlin
Gérard Eberl
Gérard Eberl Université Paris Cité
Volker Thiel
Volker Thiel University of Bern
Jan Buer
Jan Buer University of Duisburg-Essen
Klaus Heeg
Klaus Heeg University Hospital Heidelberg

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