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Microbiology

D-Index
72
Citations
19103
World Ranking
1748
National Ranking
128

Overview

Klaus Heeg is affiliated with the University Hospital Heidelberg in Germany. Their research spans multiple fields within medicine and biochemistry, genetics, and molecular biology, focusing heavily on infectious diseases and molecular medicine.

The main research topics covered by Klaus Heeg include:

  • Antibiotic Resistance in Bacteria
  • Antimicrobial Resistance in Staphylococcus
  • Bacterial Identification and Susceptibility Testing
  • Antibiotics Pharmacokinetics and Efficacy
  • Bacterial biofilms and quorum sensing
  • Antibiotic Use and Resistance
  • Vibrio bacteria research studies

Their research contributions have appeared frequently in several venues, including:

  • Journal of Antimicrobial Chemotherapy (4 publications)
  • Journal of Hospital Infection (4 publications)
  • Clinical Infectious Diseases (2 publications)
  • Frontiers in Immunology (2 publications)
  • Scientific Reports (2 publications)

Klaus Heeg has collaborated often with several coauthors, mainly:

  • Dennis Nurjadi (30 joint publications)
  • Sébastien Boutin (27 joint publications)
  • Sabrina Klein (12 joint publications)
  • Dagmar Hildebrand (8 joint publications)
  • Kaan Kocer (7 joint publications)

Selected recent publications by Klaus Heeg illustrate their focus on antibiotic resistance and infectious disease dynamics. These include:

  • Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA, 2021, Clinical Infectious Diseases
  • Surveillance for Colonization, Transmission, and Infection With Methicillin-Susceptible Staphylococcus aureus in a Neonatal Intensive Care Unit, 2021, JAMA Network Open
  • Inflammatory Response Against Staphylococcus aureus via Intracellular Sensing of Nucleic Acids in Keratinocytes, 2022, Frontiers in Immunology
  • Entry of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus into the hospital: prevalence and population structure in Heidelberg, Germany 2015-2018, 2020, Scientific Reports
  • Integrative Analysis of Whole Genome Sequencing and Phenotypic Resistance Toward Prediction of Trimethoprim-Sulfamethoxazole Resistance in Staphylococcus aureus, 2021, Frontiers in Microbiology

Their publication record shows an emphasis on antimicrobial resistance mechanisms, bacterial pathogen surveillance in healthcare settings, and molecular approaches to understanding infection biology. The combination of clinical and molecular research methods is evident throughout Klaus Heeg's work.

Best Publications

  • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells

    Tim Sparwasser;Eva Sophie Koch;Ramunas M. Vabulas;Klaus Heeg

  • CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation.

    Hans Häcker;Harald Mischak;Thomas Miethke;Susanne Liptay

  • CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis.

    Stefan Zimmermann;Oliver Egeter;Susanne Hausmann;Grayson B. Lipford

  • T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor.

    Thomas Miethke;Claudia Wahl;Klaus Heeg;Bernd Echtenacher

  • Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock.

    Tim Sparwasser;Thomas Miethke;Grayson Lipford;Andreas Erdmann

  • CpG‐containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants

    Grayson B. Lipford;Marc Bauer;Christian Blank;Rudi Reiter

  • Bacterial DNA causes septic shock

    Tim Sparwasser;Thomas Miethke;Grayson Lipford;Katrin Borschert

  • Distinct mechanisms of immunosuppression as a consequence of major surgery.

    T Hensler;H Hecker;K Heeg;C D Heidecke

  • IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice.

    Tilo Biedermann;Stephan Zimmermann;Stephan Zimmermann;Hayo Himmelrich;Alain Gumy

  • PD-L1 expression on tolerogenic APCs is controlled by STAT-3

    Sabine J. Wölfle;Julia Strebovsky;Holger Bartz;Aline Sähr

  • Immunostimulatory DNA: Sequence‐dependent production of potentially harmful or useful cytokines

    Grayson B. Lipford;Tim Sparwasser;Marc Bauer;Stefan Zimmermann

  • Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells.

    Andrea Baetz;Markus Frey;Klaus Heeg;Alexander H. Dalpke

  • Suppressors of Cytokine Signaling (SOCS)-1 and SOCS-3 Are Induced by CpG-DNA and Modulate Cytokine Responses in APCs

    Alexander H. Dalpke;Sandra Opper;Stefan Zimmermann;Klaus Heeg

  • The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype.

    Parviz Ahmad-Nejad;Salima Mrabet-Dahbi;Kristine Breuer;Martina Klotz

  • T-T cell interactions during cytotoxic T lymphocyte (CTL) responses: T cell derived helper factor (Interleukin 2) as a probe to analyze CTL responsiveness and thymic maturation of CTL progenitors.

    Hermann Wagner;Conny Hardt;Klaus Heeg;Klaus Pfizenmaier

  • T-cell-derived helper factor allows in vivo induction of cytotoxic T cells in nu/nu mice.

    Hermann Wagner;Conny Hardt;Klaus Heeg;Martin Röllinghoff

  • PHARMACEUTICAL COMPOSITION COMPRISING POLYNUCLEOTIDE AND OPTIONALLY ANTIGEN ESPECIALLY FOR VACCINATION

    Wagner Hermann;Lipford Grayson B;Heeg Klaus

  • Activation of Toll-Like Receptor 9 by DNA from Different Bacterial Species

    Alexander Dalpke;Alexander Dalpke;Jutta Frank;Mirjam Peter;Klaus Heeg

  • Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells.

    Anja K. Mayer;Mario Muehmer;Jörg Mages;Katja Gueinzius

  • Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins.

    Alexander Dalpke;Klaus Heeg;Holger Bartz;Andrea Baetz

  • DNA activates human immune cells through a CpG sequence-dependent manner.

    M Bauer;K Heeg;H Wagner;G B Lipford

Frequent Co-Authors

Hermann Wagner
Hermann Wagner Technical University of Munich
Alexander H. Dalpke
Alexander H. Dalpke Heidelberg University
Grayson B. Lipford
Grayson B. Lipford Janus Biotherapeutics (United States)
Tim Sparwasser
Tim Sparwasser Johannes Gutenberg University of Mainz
Stefan Bauer
Stefan Bauer Philipp University of Marburg
Roland Lang
Roland Lang University of Erlangen-Nuremberg
Martin Röllinghoff
Martin Röllinghoff University of Erlangen-Nuremberg
Harald Renz
Harald Renz Philipp University of Marburg
Klaus Pfeffer
Klaus Pfeffer Heinrich Heine University Düsseldorf
Paul Schnitzler
Paul Schnitzler University Hospital Heidelberg

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