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Alexander H. Dalpke

Alexander H. Dalpke

D-Index & Metrics

Immunology

D-Index
63
Citations
12804
World Ranking
3051
National Ranking
206

Overview

Alexander H. Dalpke is affiliated with Heidelberg University in Germany. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a significant focus on infectious diseases and molecular biology.

The scientist has contributed extensively to subfields such as Infectious Diseases, Molecular Biology, Pulmonary and Respiratory Medicine, Immunology, and Epidemiology. Their work covers a diverse range of topics encompassing SARS-CoV-2 and COVID-19 research, SARS-CoV-2 detection and testing, cystic fibrosis research advances, COVID-19 clinical research studies, COVID-19 epidemiological studies, gut microbiota and health, as well as respiratory viral infections research.

Selected recent papers authored or coauthored by Alexander H. Dalpke include:

  • Effects of Lumacaftor-Ivacaftor on Lung Clearance Index, Magnetic Resonance Imaging, and Airway Microbiome in Phe508del Homozygous Patients with Cystic Fibrosis, 2021, Annals of the American Thoracic Society
  • Bacterial tRNA 2'-O-methylation is dynamically regulated under stress conditions and modulates innate immune response, 2020, Nucleic Acids Research
  • Changes in the Cystic Fibrosis Airway Microbiome in Response to CFTR Modulator Therapy, 2021, Frontiers in Cellular and Infection Microbiology
  • Inflammation induces pro-NETotic neutrophils via TNFR2 signaling, 2022, Cell Reports
  • Simultaneous Detection of SARS-CoV-2 and Influenza Virus in Wastewater of Two Cities in Southeastern Germany, January to May 2022, 2022, International Journal of Environmental Research and Public Health

Frequent coauthors collaborating with Dalpke include:

  • Sébastien Boutin
  • Buqing Yi
  • Christian Lück
  • Reinhard Berner
  • Jakob Armann

Their publications are often featured in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Research Square (Research Square)
  • Frontiers in Cellular and Infection Microbiology
  • SSRN Electronic Journal

Alexander H. Dalpke's research encompasses clinical and molecular aspects of respiratory and infectious diseases, with strong contributions to understanding microbiomes, immune responses, and viral epidemiology, particularly related to COVID-19 and cystic fibrosis.

Best Publications

  • Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke.

    Arthur Liesz;Wei Zhou;Éva Mracskó;Simone Karcher

  • PD-L1 expression on tolerogenic APCs is controlled by STAT-3

    Sabine J. Wölfle;Julia Strebovsky;Holger Bartz;Aline Sähr

  • DAMP signaling is a key pathway inducing immune modulation after brain injury.

    Arthur Liesz;Arthur Liesz;Alexander Dalpke;Eva Mracsko;Daniel J. Antoine

  • Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells.

    Andrea Baetz;Markus Frey;Klaus Heeg;Alexander H. Dalpke

  • Suppressors of Cytokine Signaling (SOCS)-1 and SOCS-3 Are Induced by CpG-DNA and Modulate Cytokine Responses in APCs

    Alexander H. Dalpke;Sandra Opper;Stefan Zimmermann;Klaus Heeg

  • Infarct Volume is a Major Determiner of Post-Stroke Immune Cell Function and Susceptibility to Infection

    Andreas Hug;Alexander Dalpke;Nina Wieczorek;Thomas Giese

  • Activation of Toll-Like Receptor 9 by DNA from Different Bacterial Species

    Alexander Dalpke;Alexander Dalpke;Jutta Frank;Mirjam Peter;Klaus Heeg

  • Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells.

    Anja K. Mayer;Mario Muehmer;Jörg Mages;Katja Gueinzius

  • Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins.

    Alexander Dalpke;Klaus Heeg;Holger Bartz;Andrea Baetz

  • Suppressor of cytokine signaling 1 (SOCS1) limits NFκB signaling by decreasing p65 stability within the cell nucleus

    Julia Strebovsky;Patrick Walker;Roland Lang;Alexander H. Dalpke

  • Immunostimulatory CpG-DNA activates murine microglia.

    Alexander H. Dalpke;Martin K.-H. Schäfer;Markus Frey;Stefan Zimmermann

  • Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment

    Konrad A. Bode;Kate Schroder;David A. Hume;Timothy Ravasi

  • Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transcription of IL-6 in macrophages

    Peter J. Hanley;Boris Musset;Vijay Renigunta;Sven H. Limberg

  • Microbial DNA induces a host defense reaction of human respiratory epithelial cells.

    Juliane Platz;Christoph Beisswenger;Alexander Dalpke;Rembert Koczulla

  • Pharmacologic cholinesterase inhibition improves survival in experimental sepsis.

    Stefan Hofer;Christoph Eisenbach;Ivan K. Lukic;Ivan K. Lukic;Lutz Schneider

  • Phosphodiester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivo.

    Alexander H Dalpke;Stefan Zimmermann;Inka Albrecht;Klaus Heeg

  • The Spectrum of Systemic Immune Alterations After Murine Focal Ischemia Immunodepression Versus Immunomodulation

    Arthur Liesz;Sebastien Hagmann;Carolin Zschoche;Johanna Adamek

  • Lack of Neutrophil Elastase Reduces Inflammation, Mucus Hypersecretion, and Emphysema, but Not Mucus Obstruction, in Mice with Cystic Fibrosis–like Lung Disease

    Stefanie Gehrig;Julia Duerr;Michael Weitnauer;Claudius J. Wagner

  • Comparison of Microbiomes from Different Niches of Upper and Lower Airways in Children and Adolescents with Cystic Fibrosis

    Sébastien Boutin;Simon Y. Graeber;Michael Weitnauer;Jessica Panitz

  • Cutting Edge: TLR13 Is a Receptor for Bacterial RNA

    Asa Hidmark;Antonia von Saint Paul;Alexander H. Dalpke

  • Induction of Suppressor of Cytokine Signaling-1 by Toxoplasma gondii Contributes to Immune Evasion in Macrophages by Blocking IFN-γ Signaling

    Stefan Zimmermann;Peter J. Murray;Klaus Heeg;Alexander H. Dalpke

  • Airway epithelial cells modify immune responses by inducing an anti-inflammatory microenvironment.

    Anja K. Mayer;Holger Bartz;Fabian Fey;Lotte M. Schmidt

  • Modifications in Small Interfering RNA That Separate Immunostimulation from RNA Interference

    Florian Eberle;Kerstin Giessler;Christopher Deck;Klaus Heeg

  • Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I)

    Marco Binder;Florian Eberle;Stefan Seitz;Norbert Mücke

  • QuantiFERON TB-Gold--a new test strengthening long-suspected tuberculous involvement in serpiginous-like choroiditis.

    Friederike Mackensen;Matthias D. Becker;Ute Wiehler;Regina Max

  • The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis

    Salima Mrabet-Dahbi;Alexander H. Dalpke;Margarete Niebuhr;Markus Frey

Frequent Co-Authors

Klaus Heeg
Klaus Heeg University Hospital Heidelberg
Roland Veltkamp
Roland Veltkamp Imperial College London
Mark Helm
Mark Helm Johannes Gutenberg University of Mainz
Marcus A. Mall
Marcus A. Mall Charité - University Medicine Berlin
Arthur Liesz
Arthur Liesz Ludwig-Maximilians-Universität München
Kate Schroder
Kate Schroder University of Queensland
Matthew J. Sweet
Matthew J. Sweet University of Queensland
David A. Hume
David A. Hume University of Queensland
Peter P. Nawroth
Peter P. Nawroth Heidelberg University
Timothy Ravasi
Timothy Ravasi Okinawa Institute of Science and Technology

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