World's Best Scientists 2026 revealed!
Shimon Sakaguchi

Shimon Sakaguchi

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Immunology
Japan
2026
Award Badge
Medicine
Japan
2023

D-Index & Metrics

Immunology

D-Index
136
Citations
137253
World Ranking
180
National Ranking
10

Medicine

D-Index
136
Citations
137258
World Ranking
1927
National Ranking
36

Shimon Sakaguchi publication distribution in Immunology in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Immunology in 2026. The highlighted bar marks where Shimon Sakaguchi sits on this spectrum.

62–71 publications: 9 scientists 72–81 publications: 23 scientists 82–91 publications: 40 scientists 92–101 publications: 72 scientists 102–111 publications: 86 scientists 112–121 publications: 108 scientists 122–131 publications: 150 scientists 132–141 publications: 160 scientists 142–151 publications: 159 scientists 152–161 publications: 189 scientists 162–171 publications: 166 scientists 172–181 publications: 181 scientists 182–191 publications: 188 scientists 192–201 publications: 187 scientists 202–211 publications: 178 scientists 212–221 publications: 158 scientists 222–231 publications: 168 scientists 232–241 publications: 159 scientists 242–251 publications: 160 scientists 252–261 publications: 148 scientists 262–271 publications: 116 scientists 272–281 publications: 125 scientists 282–291 publications: 115 scientists 292–301 publications: 111 scientists 302–311 publications: 95 scientists 312–321 publications: 97 scientists 322–331 publications: 97 scientists 332–341 publications: 99 scientists 342–351 publications: 96 scientists 352–361 publications: 68 scientists 362–371 publications: 76 scientists 372–381 publications: 71 scientists 382–391 publications: 71 scientists 392–401 publications: 62 scientists 402–411 publications: 54 scientists 412–421 publications: 41 scientists 422–431 publications: 63 scientists 432–441 publications: 53 scientists 442–451 publications: 31 scientists 452–461 publications: 42 scientists 462–471 publications: 40 scientists 472–481 publications: 29 scientists 482–491 publications: 34 scientists 492–501 publications: 30 scientists 502–511 publications: 23 scientists 512–521 publications: 41 scientists 522–531 publications: 29 scientists 532–541 publications: 28 scientists 542–551 publications: 16 scientists 552–561 publications: 18 scientists 562–571 publications: 18 scientists 572–581 publications: 17 scientists 582–591 publications: 17 scientists 592–601 publications: 17 scientists 602–611 publications: 19 scientists 612–621 publications: 13 scientists 622–631 publications: 12 scientists 632–641 publications: 11 scientists 642–651 publications: 16 scientists 652–661 publications: 9 scientists 662–671 publications: 5 scientists 672–681 publications: 13 scientists 682–691 publications: 12 scientists 692–701 publications: 6 scientists 702–711 publications: 6 scientists 712–721 publications: 9 scientists 722–731 publications: 9 scientists 732–741 publications: 6 scientists 742–751 publications: 11 scientists 752–761 publications: 10 scientists 762–771 publications: 7 scientists 772–781 publications: 12 scientists 782–791 publications: 7 scientists 792–801 publications: 5 scientists 802–806 publications: 1 scientists 807+ publications: 100 scientists
62 publications 807+

This scientist: 482 publications — 88th percentile

88% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 807 publications or more.

Shimon Sakaguchi D-index placement in Immunology in 2026

The chart shows the D-index (discipline H-index) distribution of Immunology scientists ranked by Research.com in 2026. The highlighted bar marks where Shimon Sakaguchi sits on this spectrum.

40–41 D-Index: 28 scientists 42–43 D-Index: 91 scientists 44–45 D-Index: 157 scientists 46–47 D-Index: 192 scientists 48–49 D-Index: 175 scientists 50–51 D-Index: 188 scientists 52–53 D-Index: 177 scientists 54–55 D-Index: 155 scientists 56–57 D-Index: 194 scientists 58–59 D-Index: 201 scientists 60–61 D-Index: 197 scientists 62–63 D-Index: 201 scientists 64–65 D-Index: 173 scientists 66–67 D-Index: 167 scientists 68–69 D-Index: 172 scientists 70–71 D-Index: 199 scientists 72–73 D-Index: 184 scientists 74–75 D-Index: 133 scientists 76–77 D-Index: 162 scientists 78–79 D-Index: 127 scientists 80–81 D-Index: 121 scientists 82–83 D-Index: 125 scientists 84–85 D-Index: 121 scientists 86–87 D-Index: 102 scientists 88–89 D-Index: 96 scientists 90–91 D-Index: 75 scientists 92–93 D-Index: 72 scientists 94–95 D-Index: 74 scientists 96–97 D-Index: 66 scientists 98–99 D-Index: 68 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 60 scientists 104–105 D-Index: 54 scientists 106–107 D-Index: 36 scientists 108–109 D-Index: 23 scientists 110–111 D-Index: 52 scientists 112–113 D-Index: 41 scientists 114–115 D-Index: 34 scientists 116–117 D-Index: 25 scientists 118–119 D-Index: 28 scientists 120–121 D-Index: 11 scientists 122–123 D-Index: 20 scientists 124–125 D-Index: 27 scientists 126–127 D-Index: 19 scientists 128–129 D-Index: 20 scientists 130–131 D-Index: 16 scientists 132–133 D-Index: 17 scientists 134–135 D-Index: 14 scientists 136–137 D-Index: 15 scientists 138–139 D-Index: 9 scientists 140–141 D-Index: 11 scientists 142–143 D-Index: 9 scientists 144–145 D-Index: 9 scientists 146–147 D-Index: 7 scientists 148–149 D-Index: 7 scientists 150–151 D-Index: 7 scientists 152–153 D-Index: 5 scientists 154–155 D-Index: 8 scientists 156 D-Index: 6 scientists 157+ D-Index: 96 scientists
40 D-Index 157+

This scientist: 136 D-Index — 96th percentile

96% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 157 D-Index or more.

Research.com Recognitions

  • 2026 - Research.com Immunology in Japan Leader Award
  • 2025 - Research.com Immunology in Japan Leader Award
  • 2023 - Research.com Immunology in Japan Leader Award
  • 2023 - Research.com Medicine in Japan Leader Award
  • 2022 - Research.com Immunology in Japan Leader Award
  • 2020 - Paul Ehrlich and Ludwig Darmstaedter Prize
  • 2020 - Robert Koch Prize
  • 2015 - Canada Gairdner International Award
  • 2012 - Member of the National Academy of Sciences
  • 2008 - Keio Medical Science Prize, Keio University, Tokyo, Japan

Overview

Shimon Sakaguchi is affiliated with Osaka University in Japan and has an extensive research portfolio primarily in the field of Immunology and Microbiology, with 180 publications. Their work spans subfields including Immunology, Molecular Biology, Oncology, Genetics, and Infectious Diseases.

The scientist's research topics focus on immune cell function and interaction, T-cell and B-cell immunology, immunotherapy and immune responses, single-cell and spatial transcriptomics, cancer immunotherapy and biomarkers, diabetes and associated disorders, and CAR-T cell therapy research.

Major publication venues for Shimon Sakaguchi include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • The Journal of Experimental Medicine
  • Immunity
  • European Journal of Immunology

Notable recent papers by or involving this scientist include:

  • Regulatory T Cells and Human Disease, 2020, Annual Review of Immunology
  • Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells, 2021, Nature Biotechnology
  • Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy, 2023, Cancer Cell
  • Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells, 2021, Proceedings of the National Academy of Sciences
  • Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases, 2020, Cell Research

Frequent co-authors collaborating with Sakaguchi include:

  • Naganari Ohkura
  • James B. Wing
  • Norihisa Mikami
  • Yamami Nakamura
  • Ryoji Kawakami

Shimon Sakaguchi has been recognized with a number of awards, reflecting their contributions across the immunology landscape. Awards include:

  • Paul Ehrlich and Ludwig Darmstaedter Prize, 2020
  • Robert Koch Prize, 2020
  • Canada Gairdner International Award, 2015
  • Member of the National Academy of Sciences, 2012
  • Keio Medical Science Prize, Keio University, Tokyo, Japan, 2008

Best Publications

  • Control of Regulatory T Cell Development by the Transcription Factor Foxp3

    Shohei Hori;Takashi Nomura;Shimon Sakaguchi

  • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

    Shimon Sakaguchi;Noriko Sakaguchi;Masanao Asano;Misako Itoh

  • Regulatory T Cells and Immune Tolerance

    Shimon Sakaguchi;Shimon Sakaguchi;Tomoyuki Yamaguchi;Takashi Nomura;Masahiro Ono

  • Naturally Arising CD4+ Regulatory T Cells for Immunologic Self-Tolerance and Negative Control of Immune Responses

    Shimon Sakaguchi

  • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.

    Shimon Sakaguchi

  • CTLA-4 Control over Foxp3+ Regulatory T Cell Function

    Kajsa Wing;Yasushi Onishi;Yasushi Onishi;Paz Prieto-Martin;Tomoyuki Yamaguchi

  • Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

    Koji Atarashi;Takeshi Tanoue;Kenshiro Oshima;Wataru Suda

  • FOXP3 + regulatory T cells in the human immune system

    Shimon Sakaguchi;Makoto Miyara;Makoto Miyara;Cristina M. Costantino;Cristina M. Costantino;David A. Hafler;David A. Hafler

  • Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

    Takeshi Takahashi;Tomoyuki Tagami;Sayuri Yamazaki;Toshimitsu Uede

  • Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

    Makoto Miyara;Yumiko Yoshioka;Akihiko Kitoh;Tomoko Shima

  • Stimulation of CD25 + CD4 + regulatory T cells through GITR breaks immunological self-tolerance

    Jun Shimizu;Sayuri Yamazaki;Takeshi Takahashi;Yasumasa Ishida

  • Regulatory T cells: key controllers of immunologic self-tolerance.

    Shimon Sakaguchi

  • Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance.

    Shimon Sakaguchi;Noriko Sakaguchi;Jun Shimizu;Sayuri Yamazaki

  • Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

    Takeshi Takahashi;Yuhshi Kuniyasu;Masaaki Toda;Noriko Sakaguchi

  • A promoter-level mammalian expression atlas

    Alistair R.R. Forrest;Hideya Kawaji;Michael Rehli;J. Kenneth Baillie

  • Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

    Shimon Sakaguchi;Masahiro Ono;Ruka Setoguchi;Haruhiko Yagi

  • Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity.

    Jun Shimizu;Sayuri Yamazaki;Shimon Sakaguchi

  • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

    Masanao Asano;Masaaki Toda;Noriko Sakaguchi;Shimon Sakaguchi

  • Regulatory T cells in cancer immunotherapy

    Atsushi Tanaka;Shimon Sakaguchi

  • Regulatory T cells in transplantation tolerance.

    Kathryn J. Wood;Shimon Sakaguchi

  • Regulatory T cells: Meden Agan

    Shimon Sakaguchi

Frequent Co-Authors

Hiroyoshi Nishikawa
Hiroyoshi Nishikawa Nagoya University
Takashi Nomura
Takashi Nomura Kyoto University
Kathryn J. Wood
Kathryn J. Wood University of Oxford
Shohei Hori
Shohei Hori University of Tokyo
Shinji Uemoto
Shinji Uemoto Kyoto University
Nagahiro Minato
Nagahiro Minato Kyoto University
Yoshiki Miyachi
Yoshiki Miyachi Kyoto University
Kiyoshi Takeda
Kiyoshi Takeda Osaka University
Atsushi Kumanogoh
Atsushi Kumanogoh Osaka University
Alan N. Houghton
Alan N. Houghton Memorial Sloan Kettering Cancer Center

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