D-Index & Metrics Best Publications
Immunology
Japan
2022

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 128 Citations 112,091 339 World Ranking 85 National Ranking 6
Medicine D-index 130 Citations 114,530 354 World Ranking 998 National Ranking 14

Research.com Recognitions

Awards & Achievements

2022 - Research.com Immunology in Japan Leader Award

2020 - Paul Ehrlich and Ludwig Darmstaedter Prize

2020 - Robert Koch Prize

2015 - Canada Gairdner International Award

2012 - Member of the National Academy of Sciences

2008 - Keio Medical Science Prize, Keio University, Tokyo, Japan

Overview

What is he best known for?

The fields of study he is best known for:

  • Immune system
  • Gene
  • Cancer

Immunology, IL-2 receptor, FOXP3, Immune system and Cytotoxic T cell are his primary areas of study. His is doing research in Antigen, Autoimmunity, T cell, Immunotherapy and Self Tolerance, both of which are found in Immunology. His IL-2 receptor research incorporates themes from Interleukin 21, CD8 and Autoimmune disease.

His biological study spans a wide range of topics, including Immune homeostasis, CTLA-4, Epigenetics and Cell biology. The concepts of his Immune system study are interwoven with issues in Monoclonal antibody, Function and In vivo. His work in Cytotoxic T cell covers topics such as Molecular biology which are related to areas like Streptamer, CD1 and microRNA.

His most cited work include:

  • Control of Regulatory T Cell Development by the Transcription Factor Foxp3 (6828 citations)
  • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. (5288 citations)
  • Regulatory T Cells and Immune Tolerance (3409 citations)

What are the main themes of his work throughout his whole career to date?

Shimon Sakaguchi mainly focuses on Immunology, FOXP3, IL-2 receptor, Immune system and Cell biology. His Immunology and T cell, Antigen, Autoimmunity, Autoimmune disease and Regulatory T cell investigations all form part of his Immunology research activities. The various areas that Shimon Sakaguchi examines in his FOXP3 study include Cancer research, Transcription factor, Immune tolerance, CTLA-4 and Epigenetics.

Shimon Sakaguchi interconnects Natural killer T cell, Interleukin 21 and Antigen-presenting cell in the investigation of issues within IL-2 receptor. He has included themes like Monoclonal antibody and Effector in his Immune system study. His studies deal with areas such as Receptor, Cell and CD40 as well as Cell biology.

He most often published in these fields:

  • Immunology (84.31%)
  • FOXP3 (57.30%)
  • IL-2 receptor (42.05%)

What were the highlights of his more recent work (between 2015-2021)?

  • FOXP3 (57.30%)
  • Immunology (84.31%)
  • Immune system (39.65%)

In recent papers he was focusing on the following fields of study:

FOXP3, Immunology, Immune system, Cell biology and IL-2 receptor are his primary areas of study. His FOXP3 study combines topics in areas such as Cancer research, Epigenetics, Transcription factor, Gene and Effector. His Immunology study frequently involves adjacent topics like Cell.

His work deals with themes such as Disease and Antigen, which intersect with Immune system. His Cell biology research incorporates themes from CD28, Germinal center, Immune tolerance and T-cell receptor. His studies link CD40 with IL-2 receptor.

Between 2015 and 2021, his most popular works were:

  • Regulatory T cells in cancer immunotherapy (499 citations)
  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) (345 citations)
  • Two FOXP3 + CD4 + T cell subpopulations distinctly control the prognosis of colorectal cancers (332 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Cancer

Shimon Sakaguchi mostly deals with FOXP3, Immunology, Immune system, Autoimmunity and Cell biology. His FOXP3 study combines topics from a wide range of disciplines, such as Cancer research, T cell, CTLA-4, Transcription factor and Effector. His study in Immunology concentrates on Regulatory T cell, IL-2 receptor, Arthritis, Immune tolerance and Autoimmune disease.

In his work, Cytometry, Immunophenotyping, Immunologic Technique, Mass cytometry and Flow cytometry is strongly intertwined with Monoclonal antibody, which is a subfield of Immune system. His Autoimmunity study integrates concerns from other disciplines, such as Inflammation and Cancer. His work on Homeostasis as part of general Cell biology research is often related to Branched-chain amino acid, thus linking different fields of science.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

Shimon Sakaguchi;Noriko Sakaguchi;Masanao Asano;Misako Itoh.
Journal of Immunology (1995)

9259 Citations

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

Shohei Hori;Takashi Nomura;Shimon Sakaguchi.
Science (2003)

9012 Citations

Naturally Arising CD4+ Regulatory T Cells for Immunologic Self-Tolerance and Negative Control of Immune Responses

Shimon Sakaguchi.
Annual Review of Immunology (2004)

5151 Citations

Regulatory T Cells and Immune Tolerance

Shimon Sakaguchi;Shimon Sakaguchi;Tomoyuki Yamaguchi;Takashi Nomura;Masahiro Ono.
Cell (2008)

4542 Citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.

Shimon Sakaguchi.
Nature Immunology (2005)

3851 Citations

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

Kajsa Wing;Yasushi Onishi;Yasushi Onishi;Paz Prieto-Martin;Tomoyuki Yamaguchi.
Science (2008)

2992 Citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

Takeshi Takahashi;Tomoyuki Tagami;Sayuri Yamazaki;Toshimitsu Uede.
Journal of Experimental Medicine (2000)

2968 Citations

Regulatory T cells: key controllers of immunologic self-tolerance.

Shimon Sakaguchi.
Cell (2000)

2701 Citations

Stimulation of CD25 + CD4 + regulatory T cells through GITR breaks immunological self-tolerance

Jun Shimizu;Sayuri Yamazaki;Takeshi Takahashi;Yasumasa Ishida.
Nature Immunology (2002)

2544 Citations

Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance.

Shimon Sakaguchi;Noriko Sakaguchi;Jun Shimizu;Sayuri Yamazaki.
Immunological Reviews (2001)

2295 Citations

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