World's Best Scientists 2026 revealed!
Shimon Sakaguchi

Shimon Sakaguchi

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Immunology
Japan
2026
Award Badge
Medicine
Japan
2023

D-Index & Metrics

Immunology

D-Index
136
Citations
137253
World Ranking
180
National Ranking
10

Medicine

D-Index
136
Citations
137258
World Ranking
1927
National Ranking
36

Research.com Recognitions

  • 2026 - Research.com Immunology in Japan Leader Award
  • 2025 - Research.com Immunology in Japan Leader Award
  • 2023 - Research.com Immunology in Japan Leader Award
  • 2023 - Research.com Medicine in Japan Leader Award
  • 2022 - Research.com Immunology in Japan Leader Award
  • 2020 - Paul Ehrlich and Ludwig Darmstaedter Prize
  • 2020 - Robert Koch Prize
  • 2015 - Canada Gairdner International Award
  • 2012 - Member of the National Academy of Sciences
  • 2008 - Keio Medical Science Prize, Keio University, Tokyo, Japan

Overview

Shimon Sakaguchi is affiliated with Osaka University in Japan and has an extensive research portfolio primarily in the field of Immunology and Microbiology, with 180 publications. Their work spans subfields including Immunology, Molecular Biology, Oncology, Genetics, and Infectious Diseases.

The scientist's research topics focus on immune cell function and interaction, T-cell and B-cell immunology, immunotherapy and immune responses, single-cell and spatial transcriptomics, cancer immunotherapy and biomarkers, diabetes and associated disorders, and CAR-T cell therapy research.

Major publication venues for Shimon Sakaguchi include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • The Journal of Experimental Medicine
  • Immunity
  • European Journal of Immunology

Notable recent papers by or involving this scientist include:

  • Regulatory T Cells and Human Disease, 2020, Annual Review of Immunology
  • Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells, 2021, Nature Biotechnology
  • Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy, 2023, Cancer Cell
  • Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells, 2021, Proceedings of the National Academy of Sciences
  • Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases, 2020, Cell Research

Frequent co-authors collaborating with Sakaguchi include:

  • Naganari Ohkura
  • James B. Wing
  • Norihisa Mikami
  • Yamami Nakamura
  • Ryoji Kawakami

Shimon Sakaguchi has been recognized with a number of awards, reflecting their contributions across the immunology landscape. Awards include:

  • Paul Ehrlich and Ludwig Darmstaedter Prize, 2020
  • Robert Koch Prize, 2020
  • Canada Gairdner International Award, 2015
  • Member of the National Academy of Sciences, 2012
  • Keio Medical Science Prize, Keio University, Tokyo, Japan, 2008

Best Publications

  • Control of Regulatory T Cell Development by the Transcription Factor Foxp3

    Shohei Hori;Takashi Nomura;Shimon Sakaguchi

  • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

    Shimon Sakaguchi;Noriko Sakaguchi;Masanao Asano;Misako Itoh

  • Regulatory T Cells and Immune Tolerance

    Shimon Sakaguchi;Shimon Sakaguchi;Tomoyuki Yamaguchi;Takashi Nomura;Masahiro Ono

  • Naturally Arising CD4+ Regulatory T Cells for Immunologic Self-Tolerance and Negative Control of Immune Responses

    Shimon Sakaguchi

  • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.

    Shimon Sakaguchi

  • CTLA-4 Control over Foxp3+ Regulatory T Cell Function

    Kajsa Wing;Yasushi Onishi;Yasushi Onishi;Paz Prieto-Martin;Tomoyuki Yamaguchi

  • Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

    Koji Atarashi;Takeshi Tanoue;Kenshiro Oshima;Wataru Suda

  • FOXP3 + regulatory T cells in the human immune system

    Shimon Sakaguchi;Makoto Miyara;Makoto Miyara;Cristina M. Costantino;Cristina M. Costantino;David A. Hafler;David A. Hafler

  • Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

    Takeshi Takahashi;Tomoyuki Tagami;Sayuri Yamazaki;Toshimitsu Uede

  • Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

    Makoto Miyara;Yumiko Yoshioka;Akihiko Kitoh;Tomoko Shima

  • Stimulation of CD25 + CD4 + regulatory T cells through GITR breaks immunological self-tolerance

    Jun Shimizu;Sayuri Yamazaki;Takeshi Takahashi;Yasumasa Ishida

  • Regulatory T cells: key controllers of immunologic self-tolerance.

    Shimon Sakaguchi

  • Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance.

    Shimon Sakaguchi;Noriko Sakaguchi;Jun Shimizu;Sayuri Yamazaki

  • Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

    Takeshi Takahashi;Yuhshi Kuniyasu;Masaaki Toda;Noriko Sakaguchi

  • A promoter-level mammalian expression atlas

    Alistair R.R. Forrest;Hideya Kawaji;Michael Rehli;J. Kenneth Baillie

  • Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

    Shimon Sakaguchi;Masahiro Ono;Ruka Setoguchi;Haruhiko Yagi

  • Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity.

    Jun Shimizu;Sayuri Yamazaki;Shimon Sakaguchi

  • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

    Masanao Asano;Masaaki Toda;Noriko Sakaguchi;Shimon Sakaguchi

  • Regulatory T cells in cancer immunotherapy

    Atsushi Tanaka;Shimon Sakaguchi

  • Regulatory T cells in transplantation tolerance.

    Kathryn J. Wood;Shimon Sakaguchi

  • Regulatory T cells: Meden Agan

    Shimon Sakaguchi

Frequent Co-Authors

Hiroyoshi Nishikawa
Hiroyoshi Nishikawa Nagoya University
Takashi Nomura
Takashi Nomura Kyoto University
Kathryn J. Wood
Kathryn J. Wood University of Oxford
Shohei Hori
Shohei Hori University of Tokyo
Shinji Uemoto
Shinji Uemoto Kyoto University
Nagahiro Minato
Nagahiro Minato Kyoto University
Yoshiki Miyachi
Yoshiki Miyachi Kyoto University
Kiyoshi Takeda
Kiyoshi Takeda Osaka University
Atsushi Kumanogoh
Atsushi Kumanogoh Osaka University
Alan N. Houghton
Alan N. Houghton Memorial Sloan Kettering Cancer Center

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