D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 91 Citations 29,890 297 World Ranking 408 National Ranking 36
Medicine D-index 97 Citations 34,167 351 World Ranking 4315 National Ranking 406

Research.com Recognitions

Awards & Achievements

Fellow of The Academy of Medical Sciences, United Kingdom

Overview

What is he best known for?

The fields of study he is best known for:

  • Immune system
  • Gene
  • Internal medicine

His main research concerns Immunology, IL-2 receptor, Transplantation, T cell and Immune system. Robert I. Lechler usually deals with Immunology and limits it to topics linked to Cytotoxic T cell and Cell biology. His studies in IL-2 receptor integrate themes in fields like Interleukin 21 and FOXP3.

The various areas that he examines in his Transplantation study include Immunosuppression, Allograft Tolerance and Bioinformatics. His T cell research incorporates elements of Epitope, Molecular biology and Receptor. Robert I. Lechler interconnects Endocrinology, Internal medicine and Histocompatibility in the investigation of issues within Immune system.

His most cited work include:

  • Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression (1835 citations)
  • Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency (1210 citations)
  • Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. (706 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Immunology, Transplantation, T cell, Cell biology and Immune system. His research on Immunology frequently connects to adjacent areas such as Cytotoxic T cell. Robert I. Lechler has researched Transplantation in several fields, including Regulatory T cell, Immunosuppression, Immune tolerance and Cell therapy.

His T cell study incorporates themes from Molecular biology, Cell culture, CD8 and Major histocompatibility complex. His Cell biology course of study focuses on CD80 and CD86. His IL-2 receptor research is multidisciplinary, incorporating elements of Interleukin 21, Cancer research, FOXP3 and Adoptive cell transfer.

He most often published in these fields:

  • Immunology (58.79%)
  • Transplantation (30.86%)
  • T cell (23.24%)

What were the highlights of his more recent work (between 2012-2021)?

  • Immunology (58.79%)
  • Transplantation (30.86%)
  • Immune system (18.16%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Immunology, Transplantation, Immune system, Regulatory T cell and Cell biology. His works in Immune tolerance, Adoptive cell transfer, Antigen, FOXP3 and Allorecognition are all subjects of inquiry into Immunology. His Antigen research includes elements of Transplant rejection and Antigen-presenting cell.

His Transplantation research includes themes of Tolerance induction, Immunosuppression, Major histocompatibility complex and Cell therapy. His study looks at the intersection of Major histocompatibility complex and topics like CD8 with T cell. The Cell biology study combines topics in areas such as Inflammation, Dendritic cell and IL-2 receptor.

Between 2012 and 2021, his most popular works were:

  • Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation (201 citations)
  • Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection. (127 citations)
  • Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection. (127 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Internal medicine

His scientific interests lie mostly in Immunology, Transplantation, Regulatory T cell, Immune system and Immunosuppression. His work in Immune tolerance, Adoptive cell transfer, Antigen, Immunity and Humanized mouse are all subfields of Immunology research. His Transplantation research integrates issues from Cell therapy, FOXP3 and Immunotherapy.

His work carried out in the field of Immune system brings together such families of science as Microvesicles, microRNA and Cell biology. His research in Immunosuppression intersects with topics in Organ transplantation, Clinical trial, Liver transplantation and Kidney transplantation. Robert I. Lechler has included themes like T cell and Leukapheresis in his Liver transplantation study.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

Graham M. Lord;Giuseppe Matarese;Jane K. Howard;Richard J. Baker.
Nature (1998)

2563 Citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

I. Sadaf Farooqi;Giuseppe Matarese;Graham M. Lord;Julia M. Keogh.
Journal of Clinical Investigation (2002)

1704 Citations

Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells.

R. I. Lechler;Ji R. Batchelor.
Journal of Experimental Medicine (1982)

1102 Citations

The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease

Ben Afzali;Giovanna Lombardi;Robert Lechler;Graham Lord.
Clinical and Experimental Immunology (2007)

883 Citations

Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.

Wan Fai Ng;Phillip J. Duggan;Frederique Ponchel;Giuseppe Matarese.
Blood (2001)

719 Citations

Identification of a B cell signature associated with renal transplant tolerance in humans

Kenneth A. Newell;Adam Asare;Allan D. Kirk;Trang D. Gisler.
Journal of Clinical Investigation (2010)

629 Citations

Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice

Jane K. Howard;Graham M. Lord;Giuseppe Matarese;Silvia Vendetti.
Journal of Clinical Investigation (1999)

619 Citations

Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells.

Marina I. Garín;Chung-Ching Chu;Dela Golshayan;Dela Golshayan;Eva Cernuda-Morollón.
Blood (2007)

583 Citations

Anergic T cells as suppressor cells in vitro.

Giovanna Lombardi;Sid Sidhu;Richard Batchelor;Robert Lechler.
Science (1994)

543 Citations

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

Pervinder Sagoo;Esperanza Perucha;Birgit Sawitzki;Stefan Tomiuk.
Journal of Clinical Investigation (2010)

504 Citations

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