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Immunology

D-Index
104
Citations
41180
World Ranking
612
National Ranking
56

Medicine

D-Index
104
Citations
41295
World Ranking
7031
National Ranking
687

Research.com Recognitions

  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Robert I. Lechler is affiliated with King's College London in the United Kingdom. Their research primarily focuses on the fields of Medicine and Immunology and Microbiology, with significant contributions in Immunology, Transplantation, and Oncology. Other subfields addressed include Public Health, Environmental and Occupational Health, as well as Physiology.

The main topics of their work cover T-cell and B-cell Immunology, Immune Cell Function and Interaction, Renal Transplantation Outcomes and Treatments, CAR-T cell therapy research, Immunotherapy and Immune Responses, Health and Medical Research Impacts, and Organ Donation and Transplantation.

The scientist has published papers in a variety of journals, frequently appearing in the European Journal of Immunology, American Journal of Transplantation, Frontiers in Immunology, EBioMedicine, and The Lancet.

Recent papers include:

  • Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials, 2020, The Lancet
  • Feasibility, long-term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients, 2020, American Journal of Transplantation
  • The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology, 2020, Frontiers in Immunology
  • PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype, 2021, PLoS Biology
  • Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive, 2021, European Journal of Immunology

Frequent co-authors include:

  • Giovanna Lombardi
  • Cristiano Scottà
  • Qi Peng
  • Lesley A. Smyth
  • Gilbert O. Fruhwirth

Lechler's research spans numerous aspects of immune regulation, transplantation, and cell therapy, reflecting sustained engagement with emerging techniques such as CAR-T cell applications and regulatory T cell function.

The scientist has been recognized as a Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

    Graham M. Lord;Giuseppe Matarese;Jane K. Howard;Richard J. Baker

  • Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

    I. Sadaf Farooqi;Giuseppe Matarese;Graham M. Lord;Julia M. Keogh

  • Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells.

    R. I. Lechler;Ji R. Batchelor

  • The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease

    Ben Afzali;Giovanna Lombardi;Robert Lechler;Graham Lord

  • Identification of a B cell signature associated with renal transplant tolerance in humans

    Kenneth A. Newell;Adam Asare;Allan D. Kirk;Trang D. Gisler

  • Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.

    Wan Fai Ng;Phillip J. Duggan;Frederique Ponchel;Giuseppe Matarese

  • Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice

    Jane K. Howard;Graham M. Lord;Giuseppe Matarese;Silvia Vendetti

  • Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells

    Marina I. Garín;Chung-Ching Chu;Dela Golshayan;Dela Golshayan;Eva Cernuda-Morollón

  • Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

    Pervinder Sagoo;Esperanza Perucha;Birgit Sawitzki;Stefan Tomiuk

  • Organ transplantation—how much of the promise has been realized?

    Robert I Lechler;Megan Sykes;Angus W Thomson;Laurence A Turka

  • Anergic T cells as suppressor cells in vitro.

    Giovanna Lombardi;Sid Sidhu;Richard Batchelor;Robert Lechler

  • A Novel Pathway of Alloantigen Presentation by Dendritic Cells

    Osquel Barroso Herrera;Dela Golshayan;Rebecca Tibbott;Francisco Salcido Ochoa

  • Requirement for Leptin in the Induction and Progression of Autoimmune Encephalomyelitis

    Giuseppe Matarese;Antonio Di Giacomo;Veronica Sanna;Graham M. Lord

  • Characterization and Clinical Application of Human CD34+ Stem/Progenitor Cell Populations Mobilized into the Blood by Granulocyte Colony-Stimulating Factor

    Myrtle Y. Gordon;Nataša Levičar;Madhava Pai;Philippe Bachellier

  • Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

    Pervinder Sagoo;Niwa Ali;Garima Garg;Frank O. Nestle

  • Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses

    Veronica Sanna;Antonio Di Giacomo;Antonio La Cava;Robert I. Lechler

  • Splicing by overlap extension by PCR using asymmetric amplification: an improved technique for the generation of hybrid proteins of immunological interest

    Anthony N Warrens;Michael D Jones;Robert I Lechler

  • Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.

    Birgit Sawitzki;Paul N Harden;Petra Reinke;Aurélie Moreau

  • Dendritic Cells in Transplantation—Friend or Foe?

    Robert Lechler;Wan Fai Ng;Ralph M. Steinman

  • The molecular basis of alloreactivity.

    Robert I Lechler;Giovanna Lombardi;J Richard Batchelor;Nancy Reinsmoen

  • In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance.

    Dela Golshayan;Shuiping Jiang;Shuiping Jiang;Julia Tsang;Julia Tsang;Marina I. Garin;Marina I. Garin

Frequent Co-Authors

Giovanna Lombardi
Giovanna Lombardi King's College London
Graham M. Lord
Graham M. Lord University of Manchester
Federica M. Marelli-Berg
Federica M. Marelli-Berg Queen Mary University of London
Andrew J. T. George
Andrew J. T. George Imperial College London
John H. McVey
John H. McVey University of Surrey
Giuseppe Matarese
Giuseppe Matarese Yale University
Kathryn J. Wood
Kathryn J. Wood University of Oxford
Edward G. D. Tuddenham
Edward G. D. Tuddenham University College London
Kristian Riesbeck
Kristian Riesbeck Lund University
Alan D. Salama
Alan D. Salama University College London

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