World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
124
Citations
67740
World Ranking
294
National Ranking
187

Medicine

D-Index
125
Citations
68406
World Ranking
3049
National Ranking
1683

Overview

David H. Sachs is affiliated with Columbia University in the United States and has a significant body of research primarily in the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work spans various subfields including Surgery, Genetics, Molecular Biology, Immunology, and Transplantation.

The scientist's research contributions focus on several main topics such as xenotransplantation and immune response, organ transplantation techniques and outcomes, virus-based gene therapy research, tissue engineering and regenerative medicine, animal genetics and reproduction, T-cell and B-cell immunology, and CRISPR and genetic engineering.

Frequent co-authors include Megan Sykes, Joshua Weiner, Kazuhiko Yamada, Dilrukshi Ekanayake-Alper, and Daniel J. Garry, with collaborative counts ranging from 6 to 12 publications each.

Their publications have appeared in multiple venues with the highest number of contributions in the journal Transplantation, followed by Xenotransplantation, American Journal of Transplantation, Circulation, and Frontiers in Immunology.

Recent papers include:

  • CD2 Immunobiology, 2020, Frontiers in Immunology
  • Progress in xenotransplantation: overcoming immune barriers, 2022, Nature Reviews Nephrology
  • Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig-to-baboon xenotransplantation, 2021, Xenotransplantation
  • Antibody reactivity with new antigens revealed in multi-transgenic triple knockout pigs may cause early loss of pig kidneys in baboons, 2020, Xenotransplantation
  • Cutaneous leukocyte lineages in tolerant large animal and immunosuppressed clinical vascularized composite allograft recipients, 2020, American Journal of Transplantation

Best Publications

  • Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.

    Daniel Blanco-Melo;Benjamin E. Nilsson-Payant;Wen Chun Liu;Skyler Uhl

  • Identification of a monoclonal antibody specific for a murine T3 polypeptide

    Oberdan Leo;Michele Foo;David H. Sachs;Lawrence E. Samelson

  • International standardization of criteria for the histologic diagnosis of renal allograft rejection : the Banff working classification of kidney transplant pathology

    K.i.m. Solez;Roy A. Axelsen;Hallgrimur Benediktsson;James F. Burdick

  • Epidermal Langerhans cells are derived from cells originating in bone marrow.

    Stephen I. Katz;Kunihiko Tamaki;David H. Sachs

  • HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression

    Tatsuo Kawai;A. Benedict Cosimi;Thomas Richard Spitzer;Nina Ellen Tolkoff-Rubin

  • Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

    K Ozato;N Mayer;D H Sachs

  • Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts

    Suzanne T. Ildstad;David H. Sachs

  • Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen.

    Y Sharabi;D H Sachs

  • Establishment and Characterization of BALB/c Lymphoma Lines with B Cell Properties

    K J Kim;C Kanellopoulos-Langevin;R M Merwin;D H Sachs

  • Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

    Kazuhiko Yamada;Koji Yazawa;Akira Shimizu;Takehiro Iwanaga

  • Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience.

    Kenji Kuwaki;Yau Lin Tseng;Frank J.M.F. Dor;Akira Shimizu

  • Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.

    K Ozato;D H Sachs

  • Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand.

    Kawai T;Andrews D;Colvin Rb;Sachs Dh

  • Transplantation in miniature swine. I. Fixation of the major histocompatibility complex.

    David H. Sachs;George Leight;James Cone;Susan Schwarz

  • Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys.

    T Kawai;A B Cosimi;R B Colvin;J Powelson

  • Monoclonal antibodies to mouse major histocompatibility complex antigens.

    Keiko Ozato;Nanci M. Mayer;David H. Sachs

  • Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism.

    T R Spitzer;F Delmonico;N Tolkoff-Rubin;S McAfee

  • Production of α-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations

    Donna Kolber-Simonds;Liangxue Lai;Steven R. Watt;Maria Denaro

  • The promise of organ and tissue preservation to transform medicine

    Sebastian Giwa;Jedediah K Lewis;Luis Alvarez;Luis Alvarez;Luis Alvarez;Robert Langer

  • Preparation and characterization of monoclonal antibodies reactive with porcine PBL.

    M D Pescovitz;J K Lunney;D H Sachs

Frequent Co-Authors

Megan Sykes
Megan Sykes Columbia University
Robert B. Colvin
Robert B. Colvin Harvard University
David K. C. Cooper
David K. C. Cooper University of Pittsburgh
Jay A. Fishman
Jay A. Fishman Harvard University
Cosimi Ab
Cosimi Ab Harvard University
Keiko Ozato
Keiko Ozato Eunice Kennedy Shriver National Institute of Child Health and Human Development
John C. Wain
John C. Wain Harvard University
Jeffrey A. Bluestone
Jeffrey A. Bluestone University of California, San Francisco
Joan K. Lunney
Joan K. Lunney Agricultural Research Service
Simon C. Robson
Simon C. Robson Beth Israel Deaconess Medical Center

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