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Medicine

D-Index
99
Citations
36300
World Ranking
8592
National Ranking
4428

Overview

John C. Wain is a researcher affiliated with Harvard University in the United States. Their work primarily focuses on the field of Medicine, with specific interests in Oncology and Neurology. The research contributions span several specialized topics including Cancer Immunotherapy and Biomarkers, Neuroblastoma Research and Treatments, and Lung Cancer Research Studies.

Their recent publication record includes a notable paper titled "Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies", published in 2025 in the journal Cancer Immunology Research. This paper has contributed to the ongoing exploration of immune checkpoint therapies and cellular immunotherapy strategies.

Frequent coauthors on their publications encompass a range of collaborators, reflecting a multidisciplinary approach. These include:

  • Michael Wichroski
  • Si-Qi Liu
  • Lauren M. Zasadil
  • Joseph L. Benci
  • Patrick C. Gedeon

John C. Wain's research outputs are predominantly published in venues associated with cancer immunology, notably Cancer Immunology Research, which is the primary venue for their publications.

The main fields and subfields that define their scientific contributions are:

  • Medicine
  • Oncology
  • Neurology

The core topics addressed in their work focus on:

  • Cancer Immunotherapy and Biomarkers
  • Neuroblastoma Research and Treatments
  • Lung Cancer Research Studies

This profile outlines John C. Wain's active engagement in cutting-edge biomedical research, emphasizing immunotherapy and targeted cancer treatment research. Their network of collaborators and choice of specialized journals indicate a focus on advancing understanding and therapeutic approaches within oncology and related neurological conditions.

Best Publications

  • Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

    Lecia V. Sequist;Belinda A. Waltman;Dora Dias-Santagata;Subba Digumarthy

  • Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

    Ryohei Katayama;Alice T. Shaw;Alice T. Shaw;Tahsin M. Khan;Tahsin M. Khan;Mari Mino-Kenudson

  • Inhaled Nitric Oxide: A Selective Pulmonary Vasodilator Reversing Hypoxic Pulmonary Vasoconstriction

    C. Frostell;M. D. Fratacci;J. C. Wain;R. Jones

  • Lymphatic metastasis in the absence of functional intratumor lymphatics.

    Timothy P. Padera;Ananth Kadambi;Emmanuelle di Tomaso;Carla Mouta Carreira

  • The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.

    Andrew M Tager;Peter LaCamera;Barry S Shea;Gabriele S Campanella

  • Bronchogenic carcinoma: analysis of staging in the mediastinum with CT by correlative lymph node mapping and sampling.

    Theresa C. McLoud;Pierre M. Bourgouin;Pierre M. Bourgouin;Rona W. Greenberg;Rona W. Greenberg;John P. Kosiuk

  • Postintubation tracheal stenosis ☆ ☆☆ ★ ★★ ♢: Treatment and results

    Hermes C. Grillo;Dean M. Donahue;Douglas J. Mathisen;John C. Wain

  • Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells

    Eric J. Duell;John K. Wiencke;Tsun-Jen Cheng;Andrea Varkonyi

  • Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease: Risk to relatives for airflow obstruction and chronic bronchitis

    Edwin K. Silverman;Harold A. Chapman;Jeffrey M. Drazen;Scott T. Weiss

  • Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice

    L. V. Sequist;R. S. Heist;A. T. Shaw;P. Fidias

  • Anastomotic complications after tracheal resection: prognostic factors and management.

    Cameron D. Wright;Hermes C. Grillo;John C. Wain;Daniel R. Wong

  • p16INK4a and Histology-specific Methylation of CpG Islands by Exposure to Tobacco Smoke in Non-Small Cell Lung Cancer

    Duk Hwan Kim;Heather H. Nelson;John K. Wiencke;Shichun Zheng

  • XPD and XRCC1 Genetic Polymorphisms Are Prognostic Factors in Advanced Non—Small-Cell Lung Cancer Patients Treated With Platinum Chemotherapy

    Sarada Gurubhagavatula;Geoffrey Liu;Sohee Park;Wei Zhou

  • Vaccination With Irradiated Autologous Tumor Cells Engineered to Secrete Granulocyte-Macrophage Colony-Stimulating Factor Augments Antitumor Immunity in Some Patients With Metastatic Non–Small-Cell Lung Carcinoma

    Ravi Salgia;Thomas Lynch;Arthur Skarin;Joan Lucca

  • Excision Repair Cross-Complementation Group 1 Polymorphism Predicts Overall Survival in Advanced Non-Small Cell Lung Cancer Patients Treated With Platinum-Based Chemotherapy

    Wei Zhou;Sarada Gurubhagavatula;Geoffrey Liu;Sohee Park

  • Potential impact on survival of improved tumor downstaging and resection rate by preoperative twice-daily radiation and concurrent chemotherapy in stage IIIA non-small-cell lung cancer

    N C Choi;R W Carey;W Daly;D Mathisen

  • The Relationship of the 6-Min Walk Test to Maximal Oxygen Consumption in Transplant Candidates With End-Stage Lung Disease

    Lawrence Cahalin;Paul Pappagianopoulos;Stella Prevost;John Wain

  • Long-term survival after resection of primary adenoid cystic and squamous cell carcinoma of the trachea and carina.

    Henning A. Gaissert;Hermes C. Grillo;M.Behgam Shadmehr;Cameron D. Wright

  • Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs

    Hongmei Mou;Rui Zhao;Richard Sherwood;Tim Ahfeldt

  • Early Age at Smoking Initiation and Tobacco Carcinogen DNA Damage in the Lung

    John K. Wiencke;Sally W. Thurston;Karl T. Kelsey;Andrea Varkonyi

Frequent Co-Authors

Douglas J. Mathisen
Douglas J. Mathisen Harvard University
David C. Christiani
David C. Christiani Harvard University
Cameron D. Wright
Cameron D. Wright Harvard University
Geoffrey Liu
Geoffrey Liu Princess Margaret Cancer Centre
Thomas J. Lynch
Thomas J. Lynch Johns Hopkins University
Hermes C. Grillo
Hermes C. Grillo Harvard University
Eugene J. Mark
Eugene J. Mark Harvard University
David H. Sachs
David H. Sachs Columbia University
Donna Neuberg
Donna Neuberg Harvard University
John K. Wiencke
John K. Wiencke University of California, San Francisco

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