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David C. Christiani

David C. Christiani

D-Index & Metrics

Medicine

D-Index
134
Citations
87776
World Ranking
2113
National Ranking
1194

Overview

David C. Christiani is affiliated with Harvard University in the United States. Their research spans multiple domains within medicine and biochemistry, genetics, and molecular biology. The scientist has a significant focus on pulmonary and respiratory medicine, molecular biology, health, toxicology and mutagenesis, genetics, and cancer research.

Their work covers numerous topics including RNA modifications and cancer, epigenetics and DNA methylation, genetic associations and epidemiology, lung cancer treatments and mutations, heavy metal exposure and toxicity, lung cancer diagnosis and treatment, as well as air quality and health impacts.

David C. Christiani's recent publications illustrate the breadth of their research interests. Notable papers include:

  • Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society (2020) published in The Lancet Respiratory Medicine
  • Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies (2021) published in Molecular Cancer
  • Association of High Tumor Mutation Burden in Non-Small Cell Lung Cancers With Increased Immune Infiltration and Improved Clinical Outcomes of PD-L1 Blockade Across PD-L1 Expression Levels (2022) published in JAMA Oncology
  • Work-related COVID-19 transmission in six Asian countries/areas: A follow-up study (2020) published in PLoS ONE
  • Deep learning classification of lung cancer histology using CT images (2021) published in Scientific Reports

The scientist collaborates frequently with other researchers in their field. Among their most frequent co-authors are Rayjean J. Hung, Geoffrey Liu, Christopher I. Amos, Matthew B. Schabath, and John K. Field.

David C. Christiani has contributed extensively to various publication venues. The most common venues for their work include:

  • Cancer Research
  • Journal of Thoracic Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • UNC Libraries

Throughout their career, Christiani has focused on advancing knowledge in lung diseases, cancer biomarkers, and the impact of environmental factors on health. Their multidisciplinary approach integrates molecular biology techniques with epidemiological studies and clinical data analysis, reflecting a broad and impactful research portfolio.

Best Publications

  • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

    Thomas J Lynch;Daphne W Bell;Raffaella Sordella;Sarada Gurubhagavatula

  • LKB1 modulates lung cancer differentiation and metastasis

    Hongbin Ji;Matthew R. Ramsey;D. Neil Hayes;Cheng Fan

  • Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures

    Jennifer F. Bobb;Linda Valeri;Birgit Claus Henn;David C. Christiani

  • Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies.

    Seunggeun Lee;Mary J. Emond;Michael J. Bamshad;Kathleen C. Barnes

  • A SNP in a let-7 microRNA Complementary Site in the KRAS 3′ Untranslated Region Increases Non–Small Cell Lung Cancer Risk

    Lena J. Chin;Elena Ratner;Shuguang Leng;Rihong Zhai

  • Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

    James D McKay;Rayjean J Hung;Younghun Han;Xuchen Zong

  • Emergency Duties and Deaths from Heart Disease among Firefighters in the United States

    Stefanos N. Kales;Elpidoforos S. Soteriades;Costas A. Christophi;David C. Christiani

  • An Integrated View of Copy Number and Allelic Alterations in the Cancer Genome Using Single Nucleotide Polymorphism Arrays

    Xiaojun Zhao;Cheng Li;J. Guillermo Paez;Koei Chin

  • Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study

    Robert Carreras-Torres;Mattias Johansson;Philip C. Haycock;Kaitlin H. Wade

  • Phthalate exposure and human semen parameters.

    Susan M. Duty;Manori J. Silva;Dana B. Barr;John W. Brock

  • Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans.

    Samir M Parikh;Tadanori Mammoto;Aylit Schultz;Hai-Tao Yuan

  • Inflammasome-regulated cytokines are critical mediators of acute lung injury.

    Tamás Dolinay;Young Sam Kim;Judie Howrylak;Gary M. Hunninghake

  • Respiratory Health Hazards in Agriculture

    MB Schenker;David Christiani;Y Cormier;H Dimich-Ward

  • Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells

    Eric J. Duell;John K. Wiencke;Tsun-Jen Cheng;Andrea Varkonyi

  • Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes

    Joseph G. Allen;Skye S. Flanigan;Mallory LeBlanc;Jose Vallarino

  • Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion.

    Michelle Ng Gong;B Taylor Thompson;Paige Williams;Lucille Pothier

  • Gamma-glutamyltransferase and diabetes - a 4 year follow-up study

    D. H. Lee;M. H. Ha;J. H. Kim;D. C. Christiani

  • Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

    Yufei Wang;James D McKay;Thorunn Rafnar;Zhaoming Wang

  • Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta

    Heather H. Nelson;John K. Wiencke;David C. Christiani;T. J. Cheng

  • The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay.

    Susan M. Duty;Narendra P Singh;Manori J Silva;Dana B Barr

Frequent Co-Authors

Geoffrey Liu
Geoffrey Liu Princess Margaret Cancer Centre
Xihong Lin
Xihong Lin Harvard University
Rayjean J. Hung
Rayjean J. Hung Lunenfeld-Tanenbaum Research Institute
John C. Wain
John C. Wain Harvard University
Christopher I. Amos
Christopher I. Amos Baylor College of Medicine
Paul Brennan
Paul Brennan International Agency For Research On Cancer
John K. Field
John K. Field University of Liverpool
Maria Teresa Landi
Maria Teresa Landi National Institutes of Health
Angela Risch
Angela Risch University of Salzburg
Thomas J. Lynch
Thomas J. Lynch Johns Hopkins University

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