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Biology and Biochemistry

D-Index
65
Citations
18133
World Ranking
9035
National Ranking
4018

Overview

David Ayares is affiliated with the University of Maryland, Baltimore in the United States. Their research expertise spans Medicine and Biochemistry, Genetics, and Molecular Biology, with a significant focus on Surgery, Genetics, Molecular Biology, Pathology and Forensic Medicine, and Immunology as subfields.

Their scholarly contributions cover a range of topics including:

  • Xenotransplantation and immune response
  • Organ transplantation techniques and outcomes
  • Virus-based gene therapy research
  • Animal genetics and reproduction
  • Transplantation: methods and outcomes
  • Tissue engineering and regenerative medicine
  • CRISPR and genetic engineering

David Ayares has published extensively in journals specializing in transplantation and related areas. Frequent publication venues include:

  • Transplantation
  • Xenotransplantation
  • American Journal of Transplantation
  • The Journal of Heart and Lung Transplantation
  • Nature Medicine

Among the recent papers associated with their field of study are:

  • Genetically Modified Porcine-to-Human Cardiac Xenotransplantation, 2022, New England Journal of Medicine
  • Results of Two Cases of Pig-to-Human Kidney Xenotransplantation, 2022, New England Journal of Medicine
  • Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report, 2023, The Lancet
  • Pig-to-human heart xenotransplantation in two recently deceased human recipients, 2023, Nature Medicine
  • Immune response after pig-to-human kidney xenotransplantation: a multimodal phenotyping study, 2023, The Lancet

David Ayares collaborates regularly with several researchers, including:

  • David K. C. Cooper
  • Hidetaka Hara
  • Avneesh K. Singh
  • Bartley P. Griffith
  • Muhammad M. Mohiuddin

In addition to journal articles, they have contributed to book publications, including a forthcoming title:

  • MOLECULAR AND GENETIC ANALYSIS OF HOMOLOGOUS RECOMBINATION AND DEOXYRIBONUCLEIC ACID REPAIR IN MAMMALIAN CELLS., expected 2025, published by La Trobe University

Best Publications

  • Cloned pigs produced by nuclear transfer from adult somatic cells

    Irina A. Polejaeva;Shu-Hung Chen;Todd D. Vaught;Raymond L. Page

  • Production of α1,3-Galactosyltransferase-Deficient Pigs

    Carol J. Phelps;Chihiro Koike;Todd D. Vaught;Jeremy Boone

  • Targeted disruption of the α1,3-galactosyltransferase gene in cloned pigs

    Yifan Dai;Todd D. Vaught;Jeremy Boone;Shu-Hung Chen

  • Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

    Muhammad M. Mohiuddin;Avneesh K. Singh;Philip C. Corcoran;Marvin L. Thomas

  • Consistent success in life-supporting porcine cardiac xenotransplantation

    Matthias Längin;Tanja Mayr;Bruno Reichart;Sebastian Michel

  • Pig kidney graft survival in a baboon for 136 days: longest life‐supporting organ graft survival to date

    Hayato Iwase;Hong Liu;Hong Liu;Martin Wijkstrom;Huidong Zhou;Huidong Zhou

  • A porcine-derived acellular dermal scaffold that supports soft tissue regeneration: removal of terminal galactose-alpha-(1,3)-galactose and retention of matrix structure.

    Hui Xu;Hua Wan;Wenqi Zuo;Wendell Sun

  • The role of genetically engineered pigs in xenotransplantation research.

    David K.C. Cooper;Burcin Ekser;Jagdeece Ramsoondar;Carol Phelps

  • Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts.

    Hayato Iwase;Hidetaka Hara;Mohamed Ezzelarab;Tao Li;Tao Li

  • Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs.

    Jagdeece Ramsoondar;Todd Vaught;Suyapa Ball;Michael Mendicino

  • Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model.

    Kerry A. Daly;Ann M. Stewart-Akers;Hidetaka Hara;Mohamed Ezzelarab

  • Production and characterization of transgenic pigs expressing porcine CTLA4-Ig.

    Carol J. Phelps;Suyapa F. Ball;Todd D. Vaught;Amy M. Vance

  • B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months.

    M. M. Mohiuddin;P. C. Corcoran;A. K. Singh;A. Azimzadeh

  • Justification of specific genetic modifications in pigs for clinical organ xenotransplantation.

    David K. C. Cooper;Hidetaka Hara;Hayato Iwase;Takayuki Yamamoto

  • Current status of xenotransplantation and prospects for clinical application.

    Richard N. Pierson;Richard N. Pierson;Anthony Dorling;David Ayares;Michael Kenneth Rees

  • THE INNATE IMMUNE RESPONSE AND ACTIVATION OF COAGULATION IN α1,3-GALACTOSYLTRANSFERASE GENE-KNOCKOUT XENOGRAFT RECIPIENTS

    Mohamed Ezzelarab;Bertha Garcia;Agnes Azimzadeh;Hongtao Sun

  • Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation.

    Muhammad M. Mohiuddin;Avneesh K. Singh;Philip C. Corcoran;Robert F. Hoyt

  • Human dominant‐negative class II transactivator transgenic pigs – effect on the human anti‐pig T‐cell immune response and immune status

    Hidetaka Hara;William Witt;Tanner Crossley;Cassandra Long

  • Pig-to-baboon heterotopic heart transplantation - Exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

    Hayato Iwase;Burcin Ekser;Vikas Satyananda;Jay Bhama

  • Clinical Islet Xenotransplantation How Close Are We

    Dirk J. van der Windt;Rita Bottino;Goutham Kumar;Martin Wijkstrom

Frequent Co-Authors

David K. C. Cooper
David K. C. Cooper University of Pittsburgh
Richard N. Pierson
Richard N. Pierson Columbia University
Eckhard Wolf
Eckhard Wolf Ludwig-Maximilians-Universität München
Bruno Reichart
Bruno Reichart Ludwig-Maximilians-Universität München
Keith A. Reimann
Keith A. Reimann Harvard Medical School
Jorg Dieter Seebach
Jorg Dieter Seebach University of Geneva
David H. Sachs
David H. Sachs Columbia University
Michael Eckhaus
Michael Eckhaus National Institutes of Health
Massimo Trucco
Massimo Trucco Carnegie Mellon University
Megan Sykes
Megan Sykes Columbia University

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