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Hiroshi Nagashima

Hiroshi Nagashima

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
9606
World Ranking
14035
National Ranking
5922

Overview

Hiroshi Nagashima is affiliated with United Way in the United States and conducts research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans multiple subfields such as Molecular Biology, Surgery, Genetics, Physiology, and Biomedical Engineering.

The scientist's main areas of expertise focus on several topics including:

  • Xenotransplantation and immune response
  • Pluripotent Stem Cells Research
  • Muscle Physiology and Disorders
  • Animal Genetics and Reproduction
  • Pancreatic function and diabetes
  • Tissue Engineering and Regenerative Medicine
  • Virus-based gene therapy research

Nagashima has contributed to various scientific venues, frequently publishing in:

  • Regenerative Therapy
  • Laboratory Investigation
  • Journal of Clinical Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Development

Their recent publications include the following works:

  • "Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species," 2021, Development
  • "Deficiency of Circulating Monocytes Ameliorates the Progression of Myxomatous Valve Degeneration in Marfan Syndrome," 2020, Circulation
  • "A scalable, clinically severe pig model for Duchenne muscular dystrophy," 2021, Disease Models & Mechanisms
  • "The Innate Cellular Immune Response in Xenotransplantation," 2022, Frontiers in Immunology
  • "Investigation of Clinical Safety of Human iPS Cell-Derived Liver Organoid Transplantation to Infantile Patients in Porcine Model," 2020, Cell Transplantation

Among Nagashima's frequent co-authors are:

  • Hitomi Matsunari, with 24 joint publications
  • Kazuaki Nakano, with 23 joint publications
  • Ayuko Uchikura, with 17 joint publications
  • Kazuhiro Umeyama, with 15 joint publications
  • Masahito Watanabe, with 13 joint publications

Overall, Nagashima's research encompasses experimental and clinical approaches within regenerative medicine, genetic models of disease, and immune mechanisms relevant to transplantation and tissue engineering.

Best Publications

  • Birth of offspring following transplantation of cryopreserved immature testicular pieces and in-vitro microinsemination

    T. Shinohara;K. Inoue;N. Ogonuki;M. Kanatsu-Shinohara

  • Cryopreservation of porcine embryos

    Hiroshi Nagashima;Mark Brenton Nottle;Naomi Kashiwazaki

  • Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs

    Hitomi Matsunari;Hitomi Matsunari;Hiroshi Nagashima;Hiroshi Nagashima;Masahito Watanabe;Masahito Watanabe;Kazuhiro Umeyama;Kazuhiro Umeyama

  • Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle

    Nikolai Klymiuk;Andreas Blutke;Alexander Graf;Sabine Krause

  • Cysteamine enhances in vitro development of porcine oocytes matured and fertilized in vitro.

    C G Grupen;H Nagashima;M B Nottle

  • Generation of Naive-Like Porcine-Induced Pluripotent Stem Cells Capable of Contributing to Embryonic and Fetal Development

    Shuh-hei Fujishiro;Kazuaki Nakano;Yoshihisa Mizukami;Takuya Azami

  • Production of alpha 1,3-galactosyltransferase gene knockout pigs expressing both human decay-accelerating factor and N-acetylglucosaminyltransferase III.

    Yoichi Takahagi;Tatsuya Fujimura;Shuji Miyagawa;Hiroshi Nagashima

  • Remodeling of the Major Pig Xenoantigen by N-Acetylglucosaminyltransferase III in Transgenic Pig

    Shuji Miyagawa;Hiroshi Murakami;Yoichi Takahagi;Rie Nakai

  • Evolution of the Turtle Body Plan by the Folding and Creation of New Muscle Connections

    Hiroshi Nagashima;Fumiaki Sugahara;Masaki Takechi;Rolf Ericsson

  • Cryopreservation of Porcine Embryos Derived from In Vitro-Matured Oocytes

    Ritsuko Esaki;Hideto Ueda;Mayuko Kurome;Kazumasa Hirakawa

  • Xenografted Islet Cell Clusters From INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice

    Nikolai Klymiuk;Lelia van Buerck;Andrea Bähr;Monika Offers

  • Production of Transgenic-clone Pigs by the Combination of ICSI-mediated Gene Transfer with Somatic Cell Nuclear Transfer

    Mayuko Kurome;Hideto Ueda;Ryo Tomii;Katsutoshi Naruse

  • Completion of the swine genome will simplify the production of swine as a large animal biomedical model.

    Eric M Walters;Eckhard Wolf;Jeffery J Whyte;Jiude Mao

  • Dominant-negative mutant hepatocyte nuclear factor 1α induces diabetes in transgenic-cloned pigs

    Kazuhiro Umeyama;Masahito Watanabe;Hitoshi Saito;Mayuko Kurome

  • Generation of Interleukin-2 Receptor Gamma Gene Knockout Pigs from Somatic Cells Genetically Modified by Zinc Finger Nuclease-Encoding mRNA

    Masahito Watanabe;Kazuaki Nakano;Hitomi Matsunari;Hitomi Matsunari;Taisuke Matsuda

  • Permanent Neonatal Diabetes in INSC94Y Transgenic Pigs

    Simone Renner;Christina Braun-Reichhart;Andreas Blutke;Nadja Herbach

  • Knockout of exogenous EGFP gene in porcine somatic cells using zinc-finger nucleases.

    Masahito Watanabe;Kazuhiro Umeyama;Hitomi Matsunari;Shuko Takayanagi

  • Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis

    N. Klymiuk;L. Mundhenk;K. Kraehe;A. Wuensch

  • Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set

    Mayuko Kurome;Ludwig Geistlinger;Barbara Kessler;Valeri Zakhartchenko

  • Production of Live Piglets Following Cryopreservation of Embryos Derived from In Vitro-Matured Oocytes

    Hiroshi Nagashima;Katsumi Hiruma;Hitoshi Saito;Ryo Tomii

Frequent Co-Authors

Eckhard Wolf
Eckhard Wolf Ludwig-Maximilians-Universität München
Hiromitsu Nakauchi
Hiromitsu Nakauchi Stanford University
Valeri Zakhartchenko
Valeri Zakhartchenko Ludwig-Maximilians-Universität München
Masaru Okabe
Masaru Okabe Osaka University
Atsuo Ogura
Atsuo Ogura University of Tsukuba
Helmut Blum
Helmut Blum Ludwig-Maximilians-Universität München
Hanns Lochmüller
Hanns Lochmüller University of Freiburg
Benedikt Schoser
Benedikt Schoser Ludwig-Maximilians-Universität München
Eiji Kobayashi
Eiji Kobayashi Keio University
Suong-Hyu Hyon
Suong-Hyu Hyon Kagoshima University

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