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Molecular Biology

D-Index
69
Citations
18619
World Ranking
1467
National Ranking
31

Overview

Liangxue Lai is affiliated with the Guangzhou Institutes of Biomedicine and Health in China and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology and Genetics. Their research encompasses several sub-disciplines including Surgery, Immunology, and Cellular and Molecular Neuroscience.

The main research topics covered by Liangxue Lai include:

  • CRISPR and Genetic Engineering
  • RNA and protein synthesis mechanisms
  • Pluripotent Stem Cells Research
  • Advanced biosensing and bioanalysis techniques
  • RNA regulation and disease
  • Virus-based gene therapy research
  • RNA Interference and Gene Delivery

Liangxue Lai has published in various academic venues, with frequent contributions to:

  • Molecular Therapy - Nucleic Acids
  • Journal of Genetics and Genomics
  • BMC Biology
  • Nucleic Acids Research
  • Nature Communications

Their notable published papers include:

  • "A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR," 2020, Cell Death and Disease
  • "Large-Fragment Deletions Induced by Cas9 Cleavage while Not in the BEs System," 2020, Molecular Therapy - Nucleic Acids
  • "ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems," 2020, BMC Biology
  • "AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns," 2022, Nucleic Acids Research
  • "Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease," 2023, Nature Biomedical Engineering

Frequent co-authors of Liangxue Lai include:

  • Zhanjun Li
  • Shixue Gou
  • Quanjun Zhang
  • Kepin Wang
  • Zhiquan Liu

Liangxue Lai's work predominantly explores genetic engineering techniques with emphasis on CRISPR technology and base editing tools, contributing to advancements in gene therapy, RNA regulation, and molecular biology applications. Their research has addressed complex genetic modifications including base substitutions and chromosome editing in mammalian systems.

Best Publications

  • Production of α-1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning

    Liangxue Lai;Donna Kolber-Simonds;Kwang-Wook Park;Hee-Tae Cheong

  • A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

    Ronghui Li;Jialiang Liang;Su Ni;Ting Zhou

  • Generation of cloned transgenic pigs rich in omega-3 fatty acids.

    Liangxue Lai;Jing X Kang;Rongfeng Li;Jingdong Wang

  • Production of α-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations

    Donna Kolber-Simonds;Liangxue Lai;Steven R. Watt;Maria Denaro

  • Generation of Induced Pluripotent Stem Cell Lines from Tibetan Miniature Pig

    Miguel Angel Esteban;Jianyong Xu;Jiayin Yang;Meixiu Peng

  • Translocation of active mitochondria during pig oocyte maturation, fertilization and early embryo development in vitro

    QY Sun;GM Wu;L Lai;KW Park

  • MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition.

    Baojian Liao;Xichen Bao;Xichen Bao;Longqi Liu;Shipeng Feng

  • Establishment of porcine and human expanded potential stem cells

    Xuefei Gao;Xuefei Gao;Monika Nowak-Imialek;Monika Nowak-Imialek;Xi Chen;Dongsheng Chen

  • A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington's Disease.

    Sen Yan;Zhuchi Tu;Zhaoming Liu;Nana Fan

  • Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer

    Xiaoqing Zhou;Jige Xin;Jige Xin;Nana Fan;Qingjian Zou

  • Production of nuclear transfer-derived swine that express the enhanced green fluorescent protein.

    Kwang-Wook Park;Hee-Tae Cheong;Liangxue Lai;Gi-Sun Im

  • Transgenic swine for biomedicine and agriculture

    R.S Prather;R.J Hawley;D.B Carter;L Lai

  • Transgenic pig expressing the enhanced green fluorescent protein produced by nuclear transfer using colchicine‐treated fibroblasts as donor cells

    Liangxue Lai;Kwang-Wook Park;Hee-Tae Cheong;Hee-Tae Cheong;Birgit Kühholzer

  • Production of cloned pigs by using somatic cells as donors.

    Liangxue Lai;Randall S. Prather

  • Expression of Huntington’s disease protein results in apoptotic neurons in the brains of cloned transgenic pigs

    Dongshan Yang;Chuan En Wang;Bentian Zhao;Wei Li

  • Generation of PPARγ mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning

    Dongshan Yang;Huaqiang Yang;Wei Li;Bentian Zhao

  • Effective gene targeting in rabbits using RNA-guided Cas9 nucleases

    Dongshan Yang;Jie Xu;Tianqing Zhu;Jianglin Fan

  • Dynamic Events Are Differently Mediated by Microfilaments, Microtubules, and Mitogen-Activated Protein Kinase During Porcine Oocyte Maturation and Fertilization In Vitro

    Qing-Yuan Sun;Qing-Yuan Sun;Liangxue Lai;Kwang-Wook Park;Birgit Kühholzer

  • Cytoplasmic changes in relation to nuclear maturation and early embryo developmental potential of porcine oocytes: effects of gonadotropins, cumulus cells, follicular size, and protein synthesis inhibition.

    Qing-Yuan Sun;Liangxue Lai;Aaron Bonk;Randall S. Prather

  • Mosaic Gene Expression in Nuclear Transfer-Derived Embryos and the Production of Cloned Transgenic Pigs from Ear-Derived Fibroblasts

    Kwang-Wook Park;Liangxue Lai;Hee-Tae Cheong;Hee-Tae Cheong;Ryan Cabot

Frequent Co-Authors

Randall S. Prather
Randall S. Prather University of Missouri
Duanqing Pei
Duanqing Pei Westlake University
Miguel A. Esteban
Miguel A. Esteban Guangzhou Institutes of Biomedicine and Health
Heide Schatten
Heide Schatten University of Missouri
Billy N. Day
Billy N. Day University of Missouri
Xiao-Jiang Li
Xiao-Jiang Li Jinan University
Pentao Liu
Pentao Liu University of Hong Kong
Jiekai Chen
Jiekai Chen Guangzhou Institutes of Biomedicine and Health
Shihua Li
Shihua Li Southeast University
Donghai Wu
Donghai Wu Cornell University

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