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Molecular Biology

D-Index
51
Citations
11910
World Ranking
2491
National Ranking
69

Overview

Jiekai Chen is affiliated with the Guangzhou Institutes of Biomedicine and Health in China. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, encompassing a total of 164 publications in these fields.

The subfields of study represented in their work include:

  • Molecular Biology (140 publications)
  • Infectious Diseases (16 publications)
  • Immunology (12 publications)
  • Plant Science (11 publications)
  • Genetics (8 publications)

Their research covers a diverse range of topics, with significant contributions in:

  • CRISPR and Genetic Engineering (40 publications)
  • Pluripotent Stem Cells Research (40 publications)
  • RNA modifications and cancer (32 publications)
  • Single-cell and spatial transcriptomics (30 publications)
  • Chromosomal and Genetic Variations (22 publications)
  • Epigenetics and DNA Methylation (22 publications)
  • COVID-19 Clinical Research Studies (18 publications)

Jiekai Chen has published frequently in several venues, prominently including:

  • bioRxiv (Cold Spring Harbor Laboratory) with 13 publications
  • Nature Communications with 10 publications
  • Cell with 4 publications
  • Nucleic Acids Research with 4 publications
  • Cell Research with 3 publications

Their recent scientific papers include:

  • COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas, 2021, Cell
  • Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment, 2020, Cell
  • The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity, 2021, Nature
  • SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, 2021, Cell Research
  • COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas, 2021, Cell

Jiekai Chen frequently collaborates with several co-authors, including:

  • Duanqing Pei (29 joint publications)
  • Jiangping He (27 joint publications)
  • Lihui Lin (13 joint publications)
  • Andrew P. Hutchins (12 joint publications)
  • Kaixin Wu (10 joint publications)

Best Publications

  • A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

    Ronghui Li;Jialiang Liang;Su Ni;Ting Zhou

  • Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells

    Miguel Angel Esteban;Tao Wang;Baoming Qin;Jiayin Yang

  • COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas.

    Xianwen Ren;Wen Wen;Xiaoying Fan;Wenhong Hou

  • H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs

    Jiekai Chen;He Liu;Jing Liu;Jing Qi

  • Generation of Induced Pluripotent Stem Cell Lines from Tibetan Miniature Pig

    Miguel Angel Esteban;Jianyong Xu;Jiayin Yang;Meixiu Peng

  • Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming.

    Xiao Hu;Lei Zhang;Shi Qing Mao;Zheng Li

  • Vitamin C modulates TET1 function during somatic cell reprogramming

    Jiekai Chen;Lin Guo;Lei Zhang;Haoyu Wu;Haoyu Wu

  • Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming.

    Xiaopeng Liu;Hao Sun;Hao Sun;Jing Qi;Linli Wang

  • Rapamycin and other longevity‐promoting compounds enhance the generation of mouse induced pluripotent stem cells

    Taotao Chen;Li Shen;Jie Yu;Hongjiang Wan

  • The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity.

    Jiadong Liu;Jiadong Liu;Mingwei Gao;Mingwei Gao;Jiangping He;Kaixin Wu;Kaixin Wu;Kaixin Wu

  • Chromatin Accessibility Dynamics during iPSC Reprogramming

    Dongwei Li;Jing Liu;Xuejie Yang;Chunhua Zhou

  • The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters.

    Xichen Bao;Haitao Wu;Xihua Zhu;Xihua Zhu;Xiangpeng Guo;Xiangpeng Guo

  • SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target.

    Bingqing Xia;Xurui Shen;Yang He;Xiaoyan Pan

  • BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone.

    Jiekai Chen;Jing Liu;Jiaqi Yang;You Chen

  • The oncogene c-Jun impedes somatic cell reprogramming

    Jing Liu;Qingkai Han;Tianran Peng;Meixiu Peng

  • Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells.

    Quan Wang;Xinxiu Xu;Jun Li;Jing Liu

  • Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE.

    Jiangping He;Isaac A. Babarinde;Li Sun;Shuyang Xu

  • Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells.

    Jiangping He;Xiuling Fu;Meng Zhang;Fangfang He

  • PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs.

    Yongli Shan;Yongli Shan;Zechuan Liang;Zechuan Liang;Qi Xing;Qi Xing;Tian Zhang;Tian Zhang

  • Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics.

    Jiekai Chen;Jing Liu;You Chen;Jiaqi Yang

Frequent Co-Authors

Duanqing Pei
Duanqing Pei Westlake University
Miguel A. Esteban
Miguel A. Esteban Guangzhou Institutes of Biomedicine and Health
Liangxue Lai
Liangxue Lai Guangzhou Institutes of Biomedicine and Health
Li Shen
Li Shen University of Pennsylvania
Jincun Zhao
Jincun Zhao Guangzhou Medical University
Demin Wang
Demin Wang Medical College of Wisconsin
Ying Wang
Ying Wang Shanghai Jiao Tong University
Hao Wu
Hao Wu Harvard University
Guoliang Xu
Guoliang Xu Fudan University
Norbert Perrimon
Norbert Perrimon Harvard University

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