World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
105
Citations
45044
World Ranking
1187
National Ranking
707

Overview

Li Shen is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these areas, their work focuses extensively on subfields including Molecular Biology, Immunology, Cancer Research, Cell Biology, and Pulmonary and Respiratory Medicine.

The scientist's research themes include a range of topics such as Epigenetics and DNA Methylation, Genomics and Chromatin Dynamics, RNA modifications and cancer, RNA Research and Splicing, Single-cell and spatial transcriptomics, Hippo pathway signaling and YAP/TAZ, and Cancer-related gene regulation.

Li Shen has contributed to several recent publications, including:

  • Challenges of photocatalysis and their coping strategies, 2022, Chem Catalysis
  • A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis, 2022, Nature Cell Biology
  • Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses, 2022, Nature Cell Biology
  • Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota, 2024, Nature Metabolism
  • YAP drives fate conversion and chemoresistance of small cell lung cancer, 2021, Science Advances

The venues in which Li Shen frequently publishes include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • arXiv (Cornell University)
  • Nucleic Acids Research
  • Science Advances
  • Nature Cell Biology

Among frequent collaborators, Li Shen has worked with:

  • Yezhang Zhu
  • Xin-Hua Feng
  • Heng-Yu Fan
  • Pinglong Xu
  • Yun-Wen Wu

Best Publications

  • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

    Shinsuke Ito;Li Shen;Qing Dai;Susan C. Wu

  • Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

    Y. Iturria-Medina;R. C. Sotero;P. J. Toussaint;J. M. Mateos-Pérez

  • Distinct epigenomic landscapes of pluripotent and lineage-committed human cells

    R. David Hawkins;Gary C. Hon;Leonard K. Lee;QueMinh Ngo

  • Common genetic variants influence human subcortical brain structures.

    Derrek P. Hibar;Jason L. Stein;Jason L. Stein;Miguel E. Renteria;Alejandro Arias-Vasquez

  • ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases

    Li Shen;Ningyi Shao;Xiaochuan Liu;Eric J. Nestler

  • The genetic architecture of the human cerebral cortex

    Katrina L. Grasby;Neda Jahanshad;Jodie N. Painter;Lucía Colodro-Conde

  • The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

    Paul M. Thompson;Jason L. Stein;Sarah E. Medland;Derrek P. Hibar

  • Deep Learning to Improve Breast Cancer Detection on Screening Mammography

    Li Shen;Laurie R. Margolies;Joseph H. Rothstein;Eugene Fluder

  • Identification of common variants associated with human hippocampal and intracranial volumes

    Jason L Stein;Sarah E Medland;Sarah E Medland;Alejandro Arias Vasquez;Alejandro Arias Vasquez;Derrek P Hibar

  • Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort.

    Shannon L. Risacher;Andrew J. Saykin;John D. Wes;Li Shen

  • Genome-wide Analysis Reveals TET- and TDG-Dependent 5-Methylcytosine Oxidation Dynamics

    Li Shen;Hao Wu;Dinh Diep;Shinpei Yamaguchi;Shinpei Yamaguchi

  • Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans.

    Andrew J. Saykin;Li Shen;Tatiana M. Foroud;Steven G. Potkin

  • Metabolic network failures in Alzheimer's disease: A biochemical road map

    Jon B. Toledo;Jon B. Toledo;Matthias Arnold;Gabi Kastenmüller;Rui Chang

  • Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation

    Shogo Matoba;Shogo Matoba;Shogo Matoba;Yuting Liu;Yuting Liu;Yuting Liu;Falong Lu;Falong Lu;Falong Lu;Kumiko A. Iwabuchi;Kumiko A. Iwabuchi;Kumiko A. Iwabuchi

  • Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3

    Lorna A. Farrelly;Robert E. Thompson;Shuai Zhao;Ashley E. Lepack

  • Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort

    Li Shen;Sungeun Kim;Shannon L. Risacher;Kwangsik Nho

  • diffReps: detecting differential chromatin modification sites from ChIP-seq data with biological replicates.

    Li Shen;Ning-Yi Shao;Xiaochuan Liu;Ian Maze

  • Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress

    Georgia E. Hodes;Madeline L. Pfau;Immanuel Purushothaman;H. Francisca Ahn

  • A multi-model deep convolutional neural network for automatic hippocampus segmentation and classification in Alzheimer's disease.

    Manhua Liu;Fan Li;Hao Yan;Kundong Wang

  • Epigenetic regulation of brain region-specific microglia clearance activity

    Pinar Ayata;Ana Badimon;Hayley J. Strasburger;Mary Kaye Duff

Frequent Co-Authors

Andrew J. Saykin
Andrew J. Saykin Indiana University
Shannon L. Risacher
Shannon L. Risacher Indiana University
Kwangsik Nho
Kwangsik Nho Indiana University
Tatiana Foroud
Tatiana Foroud Indiana University
Eric J. Nestler
Eric J. Nestler Icahn School of Medicine at Mount Sinai
Heng Huang
Heng Huang University of Pittsburgh
Robert C. Green
Robert C. Green Brigham and Women's Hospital
Paul M. Thompson
Paul M. Thompson University of Southern California
Fillia Makedon
Fillia Makedon The University of Texas at Arlington
Michael W. Weiner
Michael W. Weiner University of California, San Francisco

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Li Shen

Trending Scientists

Recently Published Articles