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D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
17471
World Ranking
6344
National Ranking
486

Overview

Oreste Acuto is affiliated with the University of Oxford in the United Kingdom and specializes in research that intersects immunology, molecular biology, and medicine. Their work spans multiple subfields including immunology, molecular biology, radiology, nuclear medicine and imaging, oncology, and epidemiology. The focus of their research centers primarily on immune cell function and interaction, T-cell and B-cell immunology, and monoclonal and polyclonal antibodies research.

The scientist has a substantial record of publications, with a notable presence in journals such as bioRxiv (Cold Spring Harbor Laboratory), where they have published six papers, Journal of Clinical Immunology with four papers, Cell Reports and Translational Oncology with two papers each, and Nature Communications contributing to one paper in their portfolio.

Among recent papers authored or co-authored by Acuto are the following:

  • "Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles" (2020, Nature Communications)
  • "Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation" (2021, Cell Reports)
  • "Gene Editing Rescues In vitro T Cell Development of RAG2-Deficient Induced Pluripotent Stem Cells in an Artificial Thymic Organoid System" (2021, Journal of Clinical Immunology)
  • "Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells" (2020, Science Signaling)
  • "Multi-scale simulations of the T cell receptor reveal its lipid interactions, dynamics and the arrangement of its cytoplasmic region" (2021, PLoS Computational Biology)

The research topics covered by Acuto include:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Monoclonal and Polyclonal Antibodies Research
  • Lipid Membrane Structure and Behavior
  • Immune Response and Inflammation
  • Mosquito-borne diseases and control
  • HIV Research and Treatment

Collaborations in Acuto's research are frequently with several coauthors, including Dheeraj Prakaash, Antreas C. Kalli, Anna-Lisa Lanz, Graham P. Cook, and Giulia Masi. These associations indicate a collaborative approach in advancing understanding within their fields of expertise.

Best Publications

  • A modified procedure for the rapid preparation of efficiently transporting vesicles from small intestinal brush border membranes. Their use in investigating some properties of D-glucose and choline transport systems

    Markus Kessler;Oreste Acuto;Carlo Storelli;Heini Murer

  • An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

    Stefan C. Meuer;Rebecca E. Hussey;Marina Fabbi;David Fox

  • CD28-mediated co-stimulation: a quantitative support for TCR signalling

    Oreste Acuto;Frédérique Michel

  • Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor

    Stefan C. Meuer;Oreste Acuto;Rebecca E. Hussey;James C. Hodgdon

  • Constitutively active Lck kinase in T cells drives antigen receptor signal transduction.

    Konstantina Nika;Cristiana Soldani;Mogjiborahman Salek;Wolfgang Paster

  • T Cell Activation and the Cytoskeleton

    Oreste Acuto;Doreen Cantrell

  • The human T cell receptor: Appearance in ontogeny and biochemical relationship of α and β subunits on IL-2 dependent clones and T cell tumors

    Oreste Acuto;Rebecca E. Hussey;Kathleen A. Fitzgerald;Jeffrey P. Protentis

  • Tailoring T-cell receptor signals by proximal negative feedback mechanisms.

    Oreste Acuto;Vincenzo Di Bartolo;Frédérique Michel

  • Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody.

    D A Fox;R E Hussey;K A Fitzgerald;O Acuto

  • The Membrane-Microfilament Linker Ezrin Is Involved in the Formation of the Immunological Synapse and in T Cell Activation

    Anne Roumier;Jean C Olivo-Marin;Monique Arpin;Frédérique Michel

  • The human T-cell receptor.

    S C Meuer;O Acuto;T Hercend;S F Schlossman

  • CD28 as a molecular amplifier extending TCR ligation and signaling capabilities.

    Frédérique Michel;Géraldine Attal-Bonnefoy;Giorgio Mangino;Setsuko Mise-Omata

  • The Human T-Cell Receptor

    Oreste Acuto;Marina Fabbi;Armand Bensussan;Claudio Milanese

  • p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells.

    L Tuosto;F Michel;O Acuto

  • CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

    Claudine Irles;Antony Symons;Frédérique Michel;Talitha R. Bakker

  • Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

    Sophie V. Pageon;Thibault Tabarin;Yui Yamamoto;Yuanqing Ma

  • Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. II. Studies of B73.1 antibody-antigen interaction on the lymphocyte membrane.

    B Perussia;O Acuto;C Terhorst;J Faust

  • p56lck interacts via its src homology 2 domain with the ZAP-70 kinase.

    P Duplay;M Thome;F Hervé;O Acuto

  • Preferential V beta gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition.

    B Boitel;M Ermonval;P Panina-Bordignon;R A Mariuzza

  • Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination (vol 113, pg E5454, 2016)

    S V Pageon;T Tabarin;Y Yamamoto;Y Ma

Frequent Co-Authors

Ellis L. Reinherz
Ellis L. Reinherz Harvard University
Stuart F. Schlossman
Stuart F. Schlossman Harvard University
Nicholas R. J. Gascoigne
Nicholas R. J. Gascoigne National University of Singapore
Stefan Meuer
Stefan Meuer Heidelberg University
Rebecca E. Hussey
Rebecca E. Hussey Dana-Farber Cancer Institute
Andrés Alcover
Andrés Alcover Institut Pasteur
Cosima T. Baldari
Cosima T. Baldari University of Siena
Donna L. Farber
Donna L. Farber Columbia University
Armand Bensussan
Armand Bensussan Hôpital Saint-Louis
Nunzio Bottini
Nunzio Bottini University of California, San Diego

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