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Nicholas R. J. Gascoigne

Nicholas R. J. Gascoigne

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
12905
World Ranking
11382
National Ranking
46

Overview

Nicholas R. J. Gascoigne is affiliated with the National University of Singapore. Their research primarily spans the fields of Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. Within these disciplines, Gascoigne has contributed extensively to the subfields of Immunology, Oncology, Molecular Biology, Radiology, Nuclear Medicine and Imaging, and Spectroscopy.

The scientist's work focuses on several key topics including CAR-T cell therapy research, Immune Cell Function and Interaction, T-cell and B-cell Immunology, Monoclonal and Polyclonal Antibodies Research, Immunotherapy and Immune Responses, Mass Spectrometry Techniques and Applications, as well as Single-cell and spatial transcriptomics.

Gascoigne has published articles in various scientific venues with a notable frequency in:

  • Regular and Young Investigator Award Abstracts
  • Frontiers in Immunology
  • Cellular and Molecular Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology

Their recent publications include the following papers:

  • "New insights into the interactions between Blastocystis, the gut microbiota, and host immunity" (2021, PLoS Pathogens)
  • "Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells" (2020, Cellular and Molecular Immunology)
  • "Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling" (2021, Science)
  • "DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death" (2021, Nature Communications)
  • "Deciphering spatial domains from spatial multi-omics with SpatialGlue" (2024, Nature Methods)

Frequent collaborators include:

  • Joanna Brzostek
  • Jiawei Yap
  • Paul A. MacAry
  • Łukasz Wojciech
  • Ling Wu

Nicholas R. J. Gascoigne's body of work has contributed to understanding immune mechanisms and advancing therapeutic strategies involving T cells, particularly in the context of CAR-T therapies and immune signaling pathways. Their publications cover a range of investigative approaches spanning molecular to cellular immunology and integrate multidisciplinary techniques including mass spectrometry and spatial transcriptomics.

Best Publications

  • T-cell-receptor affinity and thymocyte positive selection

    S. M. Alam;P. J. Travers;J. L. Wung;W. Nasholds

  • Selective development of CD4 + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

    Jonathan Kaye;Mei Ling Hsu;Marie Elizabeth Sauron;Stephen C. Jameson

  • Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

    Mark A. Daniels;Emma Teixeiro;Jason Gill;Barbara Hausmann

  • Somatic recombination in a murine T-cell receptor gene

    Yueh-hsiu Chien;Nicholas R. J. Gascoigne;Joshua Kavaler;Nadine E. Lee

  • Genomic organization and sequence of T-cell receptor |[beta]|-chain constant- and joining-region genes

    Nicholas R. J. Gascoigne;Yueh-hsiu Chien;Daniel M. Becker;Joshua Kavaler

  • Photobleaching-Corrected FRET Efficiency Imaging of Live Cells

    Tomasz Zal;Nicholas R.J. Gascoigne

  • Hijacking and exploitation of IL-10 by intracellular pathogens.

    Stella Redpath;Peter Ghazal;Nicholas R.J Gascoigne

  • The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model.

    Caridad Rosette;Guy Werlen;Mark A Daniels;Philmore O Holman

  • Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.

    S.Munir Alam;G.Mark Davies;Christina M. Lin;Tomasz Zal

  • Murine Cytomegalovirus Infection Down-Regulates MHC Class II Expression on Macrophages by Induction of IL-10

    Stella Redpath;Ana Angulo;Nicholas R. J. Gascoigne;Peter Ghazal

  • Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection

    Tsukasa Nabekura;Minoru Kanaya;Akira Shibuya;Guo Fu

  • Control of MHC Restriction by TCR Vα CDR1 and CDR2

    Bee-Cheng Sim;Loukia Zerva;Mark I. Greene;Nicholas R. J. Gascoigne

  • Monoclonal antibody-superantigen fusion proteins: tumor-specific agents for T-cell-based tumor therapy

    M Dohlsten;L Abrahmsén;P Björk;P A Lando

  • CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse

    Jianyong Huang;Pei Fen Lo;Tomasz Zal;Nicholas R.J. Gascoigne

  • Themis controls thymocyte selection through regulation of T cell antigen receptor–mediated signaling

    Guo Fu;Sébastien Vallée;Vasily Rybakin;Marielena V McGuire

  • TCR affinity and negative regulation limit autoimmunity

    Matthew A Gronski;Jonathan M Boulter;Demetrius Moskophidis;Linh T Nguyen

  • TCR Signal Strength and T Cell Development

    Nicholas R.J. Gascoigne;Vasily Rybakin;Oreste Acuto;Joanna Brzostek

  • Variability and repertoire size of T-cell receptor V alpha gene segments.

    D M Becker;P Pattern;Y Chien;T Yokota

  • Inhibition of T Cell Receptor-Coreceptor Interactions by Antagonist Ligands Visualized by Live FRET Imaging of the T-Hybridoma Immunological Synapse

    Tomasz Żal;M.Anna Żal;Nicholas R.J. Gascoigne

  • The Vα14 NKT Cell TCR Exhibits High-Affinity Binding to a Glycolipid/CD1d Complex

    Stéphane Sidobre;Olga V. Naidenko;Bee-Cheng Sim;Nicholas R. J. Gascoigne

Frequent Co-Authors

Mark M. Davis
Mark M. Davis Stanford University
Oreste Acuto
Oreste Acuto University of Oxford
S. Munir Alam
S. Munir Alam Duke University
Yueh-hsiu Chien
Yueh-hsiu Chien Stanford University
Paul A. MacAry
Paul A. MacAry National University of Singapore
Christopher C. Goodnow
Christopher C. Goodnow Garvan Institute of Medical Research
Stephen C. Jameson
Stephen C. Jameson University of Minnesota
Stephen M. Hedrick
Stephen M. Hedrick University of California, San Diego
Tullia Lindsten
Tullia Lindsten Memorial Sloan Kettering Cancer Center
Lai Guan Ng
Lai Guan Ng Westlake University

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