His primary areas of study are T-cell receptor, Molecular biology, Cell biology, T cell and CD8. His study explores the link between T-cell receptor and topics such as Biochemistry that cross with problems in Biophysics. His Molecular biology research incorporates themes from Genetics, Gene, Coronin, Protease-activated receptor 2 and Fusion protein.
His work in the fields of Cell biology, such as Cell signaling, intersects with other areas such as Negative selection. His T cell research incorporates elements of FYN and Lymphocyte function-associated antigen 1. As a member of one scientific family, Nicholas R. J. Gascoigne mostly works in the field of CD8, focusing on Immunological synapse and, on occasion, Colocalization, Green fluorescent protein and Live cell imaging.
Nicholas R. J. Gascoigne focuses on T-cell receptor, Cell biology, T cell, Molecular biology and CD8. His T-cell receptor research integrates issues from Receptor and Major histocompatibility complex, Antigen. In his work, MHC class II is strongly intertwined with Superantigen, which is a subfield of Major histocompatibility complex.
The various areas that Nicholas R. J. Gascoigne examines in his Cell biology study include Immunological synapse and Thymocyte. Nicholas R. J. Gascoigne has included themes like Epitope, Cytotoxic T cell and CD3 in his T cell study. His Molecular biology study integrates concerns from other disciplines, such as Gene rearrangement, Gene, Locus, Alpha chain and Allelic exclusion.
Nicholas R. J. Gascoigne mainly investigates Cell biology, T cell, T-cell receptor, CD8 and Cytotoxic T cell. Nicholas R. J. Gascoigne combines subjects such as Receptor, Cell, T cell selection and Tcr signaling with his study of Cell biology. His studies deal with areas such as Acquired immune system, Cell signaling, Glycolysis, Metabolism and Function as well as T cell.
His T-cell receptor study combines topics from a wide range of disciplines, such as Major histocompatibility complex, Antigen, Signal transduction, Chimeric antigen receptor and Kinase. His studies examine the connections between CD8 and genetics, as well as such issues in Epitope, with regards to B cell and Antigen presentation. The study incorporates disciplines such as Effector, Signalling and Ligand in addition to Cytotoxic T cell.
Nicholas R. J. Gascoigne spends much of his time researching T-cell receptor, T cell, Cell biology, Antigen and CD8. His work on T cell selection as part of general T-cell receptor study is frequently linked to Context, bridging the gap between disciplines. Nicholas R. J. Gascoigne undertakes multidisciplinary investigations into T cell and Negative selection in his work.
The concepts of his Cell biology study are interwoven with issues in Cell, Conditional gene knockout and Metabolism. His research integrates issues of Receptor and Signal transduction in his study of Antigen. His CD8 research focuses on Cytotoxic T cell and how it relates to Effector, Cell growth and Cellular differentiation.
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T-cell-receptor affinity and thymocyte positive selection
S. M. Alam;P. J. Travers;J. L. Wung;W. Nasholds.
Selective development of CD4 + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
Jonathan Kaye;Mei Ling Hsu;Marie Elizabeth Sauron;Stephen C. Jameson.
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
Mark A. Daniels;Emma Teixeiro;Jason Gill;Barbara Hausmann.
Somatic recombination in a murine T-cell receptor gene
Yueh-hsiu Chien;Nicholas R. J. Gascoigne;Joshua Kavaler;Nadine E. Lee.
Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes
Nicholas R. J. Gascoigne;Yueh-hsiu Chien;Daniel M. Becker;Joshua Kavaler.
Hijacking and exploitation of IL-10 by intracellular pathogens
Stella Redpath;Peter Ghazal;Nicholas R.J Gascoigne.
Trends in Microbiology (2001)
Photobleaching-Corrected FRET Efficiency Imaging of Live Cells
Tomasz Zal;Nicholas R.J. Gascoigne.
Biophysical Journal (2004)
The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model.
Caridad Rosette;Guy Werlen;Mark A Daniels;Philmore O Holman.
Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.
S.Munir Alam;G.Mark Davies;Christina M. Lin;Tomasz Zal.
Murine Cytomegalovirus Infection Down-Regulates MHC Class II Expression on Macrophages by Induction of IL-10
Stella Redpath;Ana Angulo;Nicholas R. J. Gascoigne;Peter Ghazal.
Journal of Immunology (1999)
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