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D-Index & Metrics

Biology and Biochemistry

D-Index
83
Citations
20762
World Ranking
3574
National Ranking
1789

Overview

Roy A. Mariuzza is affiliated with the University of Maryland, College Park in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a focus on key subfields such as Immunology, Molecular Biology, Oncology, Radiology, Nuclear Medicine and Imaging, and Hepatology.

The scientist's work extensively addresses topics including Monoclonal and Polyclonal Antibodies Research, Immune Cell Function and Interaction, CAR-T Cell Therapy Research, T-cell and B-cell Immunology, Immunotherapy and Immune Responses, Hepatitis C Virus Research, and Cancer Immunotherapy and Biomarkers.

Roy A. Mariuzza has published in several frequent venues, notably:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • The Journal of Immunology
  • Journal of Medicinal Chemistry

Among the recent research papers attributed to them are:

  • The structural basis of T-cell receptor (TCR) activation: An enduring enigma, 2020, Journal of Biological Chemistry
  • The immune checkpoint receptor LAG3: Structure, function, and target for cancer immunotherapy, 2024, Journal of Biological Chemistry

They have collaborated frequently with a group of co-authors, most notably:

  • Brian G. Pierce
  • Thomas R. Fuerst
  • Pragati Agnihotri
  • Daichao Wu
  • Eric A. Toth

The breadth of Mariuzza's work highlights a significant focus on T-cell biology, immune checkpoint receptors, and cancer-focused immune responses. Their contributions to understanding T-cell receptor activation and mechanisms of immune modulation align with ongoing research efforts in immunotherapy and antibody function.

This scientist's work contributes to advancing knowledge in immune system interactions with implications for oncology, antiviral research, and therapeutic development in immunology and medicine.

Best Publications

  • Three-dimensional structure of an antigen-antibody complex at 2.8 A resolution

    A. G. Amit;R. A. Mariuzza;S. E. V. Phillips;R. J. Poljak

  • Bound water molecules and conformational stabilization help mediate an antigen-antibody association.

    T N Bhat;G A Bentley;G Boulot;M I Greene

  • Structure and Function of Natural Killer Cell Receptors: Multiple Molecular Solutions to Self, Nonself Discrimination*

    Kannan Natarajan;Nazzareno Dimasi;Jian Wang;Roy A. Mariuzza

  • Standard Nomenclature for the Superantigens Expressed by Staphylococcus

    Gerard Lina;Gregory A. Bohach;Sean P. Nair;Keiichi Hiramatsu

  • The structural basis of T cell activation by superantigens.

    Hongmin Li;Andrea Llera;Emilio L. Malchiodi;Roy A. Mariuzza

  • Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition.

    Jennifer Vistica;Julie Dam;Andrea Balbo;Emine Yikilmaz

  • The structural basis of antigen-antibody recognition.

    R. A. Mariuzza;S. E. V. Phillips;R. J. Poljak

  • Crystal structure of a T-cell receptor β-chain complexed with a superantigen

    Barry A. Fields;Emilio L. Malchiodi;Emilio L. Malchiodi;Hongmin Li;Xavier Ysern

  • Crystal Structure of a Lectin-Like Natural Killer Cell Receptor Bound to its Mhc Class I Ligand

    José Tormo;Kannan Natarajan;David H. Margulies;Roy A. Mariuzza

  • Crystal structure of the beta chain of a T cell antigen receptor

    Graham A. Bentley;Ginette Boulot;Klaus Karjalainen;Roy A. Mariuzza

  • Three-dimensional structure of an antigen-antibody complex at 6 A resolution.

    A. G. Amit;R. A. Mariuzza;S. E. V. Phillips;R. J. Poljak

  • Molecular recognition in antibody-antigen complexes.

    Eric J Sundberg;Roy A Mariuzza

  • The predicted structure of immunoglobulin D1.3 and its comparison with the crystal structure

    Cyrus Chothia;Cyrus Chothia;Arthur M. Lesk;Arthur M. Lesk;Michael Levitt;Adolfo G. Amit

  • Antigen recognition by human γδ T cells: pattern recognition by the adaptive immune system

    Craig T. Morita;Roy A. Mariuzza;Michael B. Brenner

  • Crystallographic refinement of the three-dimensional structure of the FabD1.3-lysozyme complex at 2.5-A resolution.

    T. O. Fischmann;G. A. Bentley;T. N. Bhat;G. Boulot

  • Three-Dimensional Structure of the Complex between a T Cell Receptor β Chain and the Superantigen Staphylococcal Enterotoxin B

    Hongmin Li;Andrea Llera;Daisuke Tsuchiya;Lukas Leder

  • Crystal Structure of the Vα Domain of a T Cell Antigen Receptor

    Barry A. Fields;Bertram Ober;Emilio L. Malchiodi;Marina I. Lebedeva

  • Molecular basis of antigen mimicry by an anti-idiotope

    Fields Ba;Goldbaum Fa;Ysern X;Ysern X;Poljak Rj

  • Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule.

    Yili Li;Yuping Huang;Jessica Lue;Jacqueline A Quandt

  • A mutational analysis of binding interactions in an antigen-antibody protein-protein complex.

    William Dall'Acqua;Ellen R. Goldman;Wenhong Lin;Connie Teng

Frequent Co-Authors

Roberto J. Poljak
Roberto J. Poljak University of Maryland, College Park
Hongmin Li
Hongmin Li University of Arizona
David H. Margulies
David H. Margulies National Institutes of Health
Peter Schuck
Peter Schuck National Institutes of Health
Brian G. Pierce
Brian G. Pierce University of Maryland, College Park
David M. Kranz
David M. Kranz University of Illinois at Urbana-Champaign
Steven K. H. Foung
Steven K. H. Foung Stanford University
Simon E. V. Phillips
Simon E. V. Phillips University of Oxford
Patrick M. Schlievert
Patrick M. Schlievert University of Iowa
Suzanne L. Topalian
Suzanne L. Topalian Johns Hopkins University

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