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Biology and Biochemistry

D-Index
47
Citations
9218
World Ranking
18654
National Ranking
652

Overview

John K. McCormick is a researcher affiliated with the University of Western Ontario in Canada. Their academic work spans Medicine and Immunology and Microbiology, covering a significant body of research with a focus on infectious diseases and related fields.

Their research subfields include:

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Immunology
  • Molecular Biology
  • Microbiology

Main research topics for John K. McCormick include:

  • Antimicrobial Resistance in Staphylococcus
  • Streptococcal Infections and Treatments
  • Clostridium difficile and Clostridium perfringens research
  • Immune Response and Inflammation
  • Neonatal and Maternal Infections
  • Reproductive tract infections research
  • Bacterial biofilms and quorum sensing

John K. McCormick has published numerous papers across a variety of recognized scientific journals and platforms. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS Pathogens
  • Infection and Immunity
  • Journal of Bacteriology
  • Proceedings of the National Academy of Sciences

Among the notable recent publications are:

  • "HLA class I-associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children" (2021, Journal of Clinical Investigation)
  • "The SrrAB two-component system regulates Staphylococcus aureus pathogenicity through redox sensitive cysteines" (2020, Proceedings of the National Academy of Sciences)
  • "Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes" (2020, Nature Communications)
  • "Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production" (2022, Proceedings of the National Academy of Sciences)
  • "Transposable elements drive the evolution of metazoan zinc finger genes" (2023, Genome Research)

Their frequent collaborators include:

  • Stephen W. Tuffs
  • Karine Dufresne
  • Katherine J. Kasper
  • Heather C. Craig
  • David E. Heinrichs

Best Publications

  • Potential Uses of Probiotics in Clinical Practice

    Gregor Reid;Gregor Reid;Jana Jass;M. Tom Sebulsky;John K. McCormick

  • Toxic Shock Syndrome and Bacterial Superantigens: An Update

    John K. McCormick;Jeremy M. Yarwood;Patrick M. Schlievert

  • Genome sequence of a serotype M3 strain of group A Streptococcus: Phage-encoded toxins, the high-virulence phenotype, and clone emergence

    Stephen B. Beres;Gail L. Sylva;Kent D. Barbian;Benfang Lei

  • A robust scoring system to evaluate sepsis severity in an animal model

    Bradly Shrum;Ram V Anantha;Stacey X Xu;Marisa Donnelly

  • Identification of a novel two-component regulatory system that acts in global regulation of virulence factors of Staphylococcus aureus.

    Jeremy M. Yarwood;John K. McCormick;Patrick M. Schlievert

  • Lactobacillus reuteri-produced cyclic dipeptides quench agr-mediated expression of toxic shock syndrome toxin-1 in staphylococci.

    Jingru Li;Wenliang Wang;Stacey X. Xu;Nathan A. Magarvey

  • Staphylococcal superantigens in colonization and disease.

    Stacey X. Xu;John K. McCormick

  • Characterization and expression analysis of Staphylococcus aureus pathogenicity island 3. Implications for the evolution of staphylococcal pathogenicity islands.

    Jeremy M. Yarwood;John K. McCormick;Michael L. Paustian;Paul M. Orwin

  • Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome

    Thu A Chau;Michelle L McCully;Michelle L McCully;William Brintnell;Gary An

  • MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression

    Christopher R. Shaler;Joshua J Choi;Patrick T. Rudak;Arash Memarnejadian

  • Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II.

    Yili Li;Hongmin Li;Nazzareno Dimasi;John K. McCormick

  • HLA class I-associated expansion of TRBV11-2 T cells in Multisystem Inflammatory Syndrome in Children.

    Rebecca A Porritt;Lisa Paschold;Magali Noval Rivas;Mary Hongying Cheng

  • Repression of the Staphylococcus aureus accessory gene regulator in serum and in vivo

    Jeremy M. Yarwood;John K. McCormick;Michael L. Paustian;Vivek Kapur

  • Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes.

    Eric J. Sundberg;Hongmin Li;Andrea S. Llera;John K. McCormick

  • Importance of vaginal microbes in reproductive health.

    Jingru Li;John McCormick;Alan Bocking;Gregor Reid;Gregor Reid

  • Bacterial Superantigens Bypass Lck-Dependent T Cell Receptor Signaling by Activating a Gα11-Dependent, PLC-β-Mediated Pathway

    Clara Bueno;Clara Bueno;Caitlin D. Lemke;Caitlin D. Lemke;Gabriel Criado;Gabriel Criado;Miren L. Baroja;Miren L. Baroja

  • Bacterial Superantigens Promote Acute Nasopharyngeal Infection by Streptococcus pyogenes in a Human MHC Class II-Dependent Manner

    Katherine J. Kasper;Joseph J. Zeppa;Adrienne T. Wakabayashi;Stacey X. Xu

  • Inhibition of expression of a staphylococcal superantigen-like protein by a soluble factor from Lactobacillus reuteri.

    Jennifer M. Laughton;Jennifer M. Laughton;Estelle Devillard;Estelle Devillard;David E. Heinrichs;Gregor Reid;Gregor Reid

  • Manipulation of Innate and Adaptive Immunity by Staphylococcal Superantigens.

    Stephen W Tuffs;S M Mansour Haeryfar;John K McCormick;John K McCormick

  • Antihomocitrullinated Fibrinogen Antibodies are Specific to Rheumatoid Arthritis and Frequently Bind Citrullinated Proteins/peptides

    Mathias Scinocca;David A Bell;Maud Racapé;Radha Joseph

Frequent Co-Authors

Patrick M. Schlievert
Patrick M. Schlievert University of Iowa
Joaquín Madrenas
Joaquín Madrenas University of California, Los Angeles
Gregor Reid
Gregor Reid University of Western Ontario
Jeremy P. Burton
Jeremy P. Burton University of Western Ontario
Bhagirath Singh
Bhagirath Singh University of Western Ontario
David E. Heinrichs
David E. Heinrichs University of Western Ontario
Roy A. Mariuzza
Roy A. Mariuzza University of Maryland, College Park
Gordon Dougan
Gordon Dougan University of Cambridge
Malak Kotb
Malak Kotb University of North Dakota
Gary M. Dunny
Gary M. Dunny University of Minnesota

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