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D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
11086
World Ranking
10448
National Ranking
360

Overview

David E. Heinrichs is affiliated with the University of Western Ontario in Canada and has contributed extensively to the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research focus predominantly centers on infectious diseases, with a significant body of work related to antimicrobial resistance in Staphylococcus species.

The primary research interests encompass topics such as:

  • Antimicrobial Resistance in Staphylococcus
  • Bacterial biofilms and quorum sensing
  • Clostridium difficile and Clostridium perfringens research
  • Bacterial Genetics and Biotechnology
  • Immune Response and Inflammation
  • Orthopedic Infections and Treatments
  • CRISPR and Genetic Engineering

Heinrichs has published a range of papers in notable journals, including:

  • "Nucleotide biosynthesis: the base of bacterial pathogenesis," 2022, Trends in Microbiology
  • "Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence," 2021, Nature Communications
  • "De Novo Purine Biosynthesis Is Required for Intracellular Growth of Staphylococcus aureus and for the Hypervirulence Phenotype of a purR Mutant," 2020, Infection and Immunity
  • "Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production," 2022, Proceedings of the National Academy of Sciences
  • "Autolysin-mediated peptidoglycan hydrolysis is required for the surface display of Staphylococcus aureus cell wall-anchored proteins," 2023, Proceedings of the National Academy of Sciences

Frequent co-authors collaborating with Heinrichs include:

  • Ronald S. Flannagan
  • Mariya I. Goncheva
  • Stephen W. Tuffs
  • John K. McCormick
  • Denny Chin

Their research has often appeared in venues with multiple publications such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Infection and Immunity
  • Journal of Biological Chemistry
  • Proceedings of the National Academy of Sciences
  • mBio

Heinrichs' work covers various subfields within the biological sciences, including infectious diseases, molecular biology, genetics, immunology, and surgery. This interdisciplinary approach reflects the complexity of bacterial pathogenesis and immune system interactions that characterize much of their research.

Best Publications

  • Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica

    David E. Heinrichs;Jeremy A. Yethon;Chris Whitfield

  • Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression.

    K Poole;K Tetro;Q Zhao;S Neshat

  • Staphylococcus aureus Fur Regulates the Expression of Virulence Factors That Contribute to the Pathogenesis of Pneumonia

    Victor J. Torres;Ahmed S. Attia;William J. Mason;M. Indriati Hood

  • Role of siderophore biosynthesis in virulence of Staphylococcus aureus: identification and characterization of genes involved in production of a siderophore.

    Suzanne E. Dale;Amanda Doherty-Kirby;Gilles Lajoie;David E. Heinrichs

  • Distribution of core oligosaccharide types in lipopolysaccharides from Escherichia coli.

    Karen Amor;David E. Heinrichs;Emilisa Frirdich;Kim Ziebell

  • Involvement of waaY, waaQ, and waaP in the Modification of Escherichia coliLipopolysaccharide and Their Role in the Formation of a Stable Outer Membrane *

    Jeremy A. Yethon;David E. Heinrichs;Mario A. Monteiro;Malcolm B. Perry

  • Recent developments in understanding the iron acquisition strategies of gram positive pathogens.

    Jessica R. Sheldon;David E. Heinrichs

  • Cloning and nucleotide sequence analysis of the ferripyoverdine receptor gene fpvA of Pseudomonas aeruginosa.

    K. Poole;Shadi Neshat;K. Krebes;D. E. Heinrichs

  • Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: regulation by iron and possible involvement in the secretion of the siderophore pyoverdine.

    Keith Poole;David E. Heinrichs;Shadi Neshat

  • Antimicrobial Mechanisms of Macrophages and the Immune Evasion Strategies of Staphylococcus aureus.

    Ronald S Flannagan;Bryan Heit;David E Heinrichs

  • Intracellular replication of Staphylococcus aureus in mature phagolysosomes in macrophages precedes host cell death, and bacterial escape and dissemination.

    Ronald S. Flannagan;Bryan Heit;David E. Heinrichs

  • Haem recognition by a Staphylococcus aureus NEAT domain.

    Jason C. Grigg;Christie L. Vermeiren;David E. Heinrichs;Michael E. P. Murphy

  • Demonstration of the Iron-regulated Surface Determinant (Isd) Heme Transfer Pathway in Staphylococcus aureus

    Naomi Muryoi;Michael T. Tiedemann;Mark Pluym;Johnson Cheung

  • Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus

    Johnson Cheung;Federico C. Beasley;Suya Liu;Gilles A. Lajoie

  • Identification and characterization of a membrane permease involved in iron-hydroxamate transport in Staphylococcus aureus.

    M. Tom Sebulsky;Dan Hohnstein;Meredith D. Hunter;David E. Heinrichs

  • Iron Acquisition Strategies of Bacterial Pathogens.

    Jessica R. Sheldon;Holly A. Laakso;David E. Heinrichs

  • Staphylococcus aureus Transporters Hts, Sir, and Sst Capture Iron Liberated from Human Transferrin by Staphyloferrin A, Staphyloferrin B, and Catecholamine Stress Hormones, Respectively, and Contribute to Virulence

    Federico C. Beasley;Cristina L. Marolda;Johnson Cheung;Suzana Buac

  • Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome

    Thu A Chau;Michelle L McCully;Michelle L McCully;William Brintnell;Gary An

  • Staphylococcal major autolysin (Atl) is involved in excretion of cytoplasmic proteins.

    Linda Pasztor;Anne-Kathrin Ziebandt;Mulugeta Nega;Martin Schlag

  • Involvement of SirABC in Iron-Siderophore Import in Staphylococcus aureus

    Suzanne E. Dale;M. Tom Sebulsky;David E. Heinrichs

Frequent Co-Authors

Michael E. P. Murphy
Michael E. P. Murphy University of British Columbia
Martin J. Stillman
Martin J. Stillman University of Western Ontario
Joaquín Madrenas
Joaquín Madrenas University of California, Los Angeles
Keith Poole
Keith Poole Queen's University
John K. McCormick
John K. McCormick University of Western Ontario
Chris Whitfield
Chris Whitfield University of Guelph
Eric P. Skaar
Eric P. Skaar Vanderbilt University Medical Center
Kelly S. Doran
Kelly S. Doran University of Colorado Denver
Alexander R. Horswill
Alexander R. Horswill University of Colorado Anschutz Medical Campus
John Mack
John Mack Rhodes University

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