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Chris Whitfield

Chris Whitfield

D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
25377
World Ranking
4265
National Ranking
142

Overview

Chris Whitfield is affiliated with the University of Guelph in Canada and specializes in Biochemistry, Genetics, and Molecular Biology. Their primary research areas include molecular biology, ecology, endocrinology, organic chemistry, and genetics. The scientist's work spans various topics, notably bacteriophages and microbial interactions, glycosylation and glycoproteins research, Escherichia coli research studies, carbohydrate chemistry and synthesis, bacterial genetics and biotechnology, RNA and protein synthesis mechanisms, and antibiotic resistance in bacteria.

Whitfield's publication record includes works in prominent scientific journals with the most frequent venues being:

  • Journal of Biological Chemistry
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Nature Communications
  • Nature Chemical Biology
  • EcoSal Plus

Their recent papers exemplify a focus on bacterial polysaccharide assembly, bacterial glycans, and antibiotic resistance mechanisms. Notable recent publications include:

  • "Assembly of Bacterial Capsular Polysaccharides and Exopolysaccharides," 2020, Annual Review of Microbiology
  • "Lipopolysaccharide O-antigens-bacterial glycans made to measure," 2020, Journal of Biological Chemistry
  • "Inhibiting fatty acid synthesis overcomes colistin resistance," 2023, Nature Microbiology
  • "Hypermucoviscosity Regulator RmpD Interacts with Wzc and Controls Capsular Polysaccharide Chain Length," 2023, mBio
  • "The molecular basis of regulation of bacterial capsule assembly by Wzc," 2021, Nature Communications

Chris Whitfield has collaborated extensively with several frequent co-authors, which include:

  • Lila M. Gierasch
  • F. Peter Guengerich
  • Ruma Banerjee
  • Roger Colbran
  • Peter Cresswell

Whitfield's research contributions incorporate key scientific topics such as glycosylation processes in bacteria, bacterial capsule biosynthesis, and mechanisms of antibiotic resistance, reflecting a strong interdisciplinary approach within biochemistry and molecular biology. Their work contributes to advancing understanding in bacterial genetics and biotechnology with applications in microbial interactions and carbohydrate chemistry.

Best Publications

  • Biosynthesis and Assembly of Capsular Polysaccharides in Escherichia coli

    Chris Whitfield

  • Biosynthesis and Export of Bacterial Lipopolysaccharides

    Chris Whitfield;M. Stephen Trent

  • Structure, assembly and regulation of expression of capsules in Escherichia coli

    Chris Whitfield;Ian S. Roberts

  • Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl

    Michael J. Franklin;David E. Nivens;Joel T. Weadge;P. Lynne Howell

  • Bacterial polysaccharide synthesis and gene nomenclature

    Peter R. Reeves;Matthew Hobbs;Miguel A. Valvano;Mikael Skurnik

  • Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein

    Changjiang Dong;Konstantinos Beis;Konstantinos Beis;Jutta Nesper;Jutta Nesper;Anne L. Brunkan-LaMontagne

  • Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica

    David E. Heinrichs;Jeremy A. Yethon;Chris Whitfield

  • Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance.

    Jonathan M. Stokes;Craig R. MacNair;Bushra Ilyas;Shawn French

  • Biosynthesis and expression of cell-surface polysaccharides in gram-negative bacteria

    Chris Whitfield;Miguel A. Valvano

  • Pivotal Roles of the Outer Membrane Polysaccharide Export and Polysaccharide Copolymerase Protein Families in Export of Extracellular Polysaccharides in Gram-Negative Bacteria

    Leslie Cuthbertson;Iain L. Mainprize;James H. Naismith;Chris Whitfield

  • Phosphorylation of Wzc, a tyrosine autokinase, is essential for assembly of group 1 capsular polysaccharides in Escherichia coli.

    Thomas Wugeditsch;Anne Paiment;Jennifer Hocking;Jolyne Drummelsmith

  • ABC Transporters Involved in Export of Cell Surface Glycoconjugates

    Leslie Cuthbertson;Veronica Kos;Chris Whitfield

  • Substrate specificity of bacterial oligosaccharyltransferase suggests a common transfer mechanism for the bacterial and eukaryotic systems

    Michael Wacker;Mario F. Feldman;Nico Callewaert;Michael Kowarik

  • Distribution of core oligosaccharide types in lipopolysaccharides from Escherichia coli.

    Karen Amor;David E. Heinrichs;Emilisa Frirdich;Kim Ziebell

  • Involvement of waaY, waaQ, and waaP in the Modification of Escherichia coliLipopolysaccharide and Their Role in the Formation of a Stable Outer Membrane *

    Jeremy A. Yethon;David E. Heinrichs;Mario A. Monteiro;Malcolm B. Perry

  • Structures of Lipopolysaccharides from Klebsiella pneumoniae ELUCIDATION OF THE STRUCTURE OF THE LINKAGE REGION BETWEEN CORE AND POLYSACCHARIDE O CHAIN AND IDENTIFICATION OF THE RESIDUES AT THE NON-REDUCING TERMINI OF THE OCHAINS

    Evgeny Vinogradov;Emilisa Frirdich;Leann L. MacLean;Malcolm B. Perry

  • Modulation of the surface architecture of Gram‐negative bacteria by the action of surface polymer:lipid A–core ligase and by determinants of polymer chain length

    Chris Whitfield;Paul A. Amor;Reinhard Koplin

  • Gene products required for surface expression of the capsular form of the group 1 K antigen in Escherichia coli (O9a:K30).

    Jolyne Drummelsmith;Chris Whitfield

  • Translocation of group 1 capsular polysaccharide to the surface of Escherichia coli requires a multimeric complex in the outer membrane.

    Jolyne Drummelsmith;Chris Whitfield

  • UDP-galactopyranose mutase has a novel structure and mechanism.

    David A.R. Sanders;Adam G. Staines;Stephen A. McMahon;Stephen A. McMahon;Michael R. McNeil

Frequent Co-Authors

James H. Naismith
James H. Naismith Rosalind Franklin Institute
Paul Messner
Paul Messner BOKU University
Malcolm B. Perry
Malcolm B. Perry National Research Council Canada
Todd L. Lowary
Todd L. Lowary University of Alberta
Evgeny Vinogradov
Evgeny Vinogradov National Research Council Canada
Robert C. Ford
Robert C. Ford University of Manchester
David E. Heinrichs
David E. Heinrichs University of Western Ontario
Richard F. Collins
Richard F. Collins University of Manchester
Wulf Blankenfeldt
Wulf Blankenfeldt Helmholtz Centre for Infection Research
Miguel A. Valvano
Miguel A. Valvano Queen's University Belfast

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