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D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
43166
World Ranking
9946
National Ranking
758

Overview

Mathew J. Garnett is affiliated with the Wellcome Sanger Institute in the United Kingdom. Their research output spans significant contributions in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with particular focus on Molecular Biology, Oncology, Cancer Research, Genetics, and Computational Theory and Mathematics.

The scientist's work emphasizes several main topics, including:

  • CRISPR and Genetic Engineering
  • Cancer Genomics and Diagnostics
  • Computational Drug Discovery Methods
  • Single-cell and spatial transcriptomics
  • Bioinformatics and Genomic Networks
  • Evolution and Genetic Dynamics
  • Protein Degradation and Inhibitors

Among the recent publications associated with Mathew J. Garnett are:

  • High-content CRISPR screening, 2022, Nature Reviews Methods Primers
  • Effective drug combinations in breast, colon and pancreatic cancer cells, 2022, Nature
  • Integrated cross-study datasets of genetic dependencies in cancer, 2021, Nature Communications
  • High-content CRISPR screening, 2022, Nature Reviews Methods Primers
  • Pan-cancer proteomic map of 949 human cell lines, 2022, Cancer Cell

The scientist collaborates frequently with several co-authors, including Emanuel Gonçalves, Howard Lightfoot, Matthew A. Coelho, Patricia Jaaks, and Syd Barthorpe, each appearing repeatedly in joint publications.

Mathew J. Garnett's publications appear predominantly in these venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature Communications
  • Cancer Discovery
  • Cancer Cell

Best Publications

  • Mutations of the BRAF gene in human cancer

    Helen Davies;Graham R. Bignell;Charles Cox;Philip Stephens

  • Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

    Wanjuan Yang;Jorge Soares;Patricia Greninger;Elena J. Edelman

  • Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf

    Paul T.C Wan;Mathew J Garnett;S.Mark Roe;Sharlene Lee

  • Systematic identification of genomic markers of drug sensitivity in cancer cells

    Mathew J. Garnett;Elena J. Edelman;Sonja J. Heidorn;Christopher Greenman;Christopher Greenman

  • Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

    Marc van de Wetering;Hayley E. Francies;Joshua M. Francis;Joshua M. Francis;Gergana Bounova

  • A Landscape of Pharmacogenomic Interactions in Cancer

    Francesco Iorio;Francesco Iorio;Theo A. Knijnenburg;Theo A. Knijnenburg;Daniel J. Vis;Graham R. Bignell

  • Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

    Fiona M. Behan;Francesco Iorio;Francesco Iorio;Gabriele Picco;Emanuel Gonçalves

  • Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

    Laura Broutier;Gianmarco Mastrogiovanni;Monique M.A. Verstegen;Hayley E. Francies

  • Guilty as charged: B-RAF is a human oncogene

    Mathew J. Garnett;Richard Marais

  • Perturbation-response genes reveal signaling footprints in cancer gene expression.

    Michael Schubert;Bertram Klinger;Martina Klünemann;Martina Klünemann;Anja Sieber;Anja Sieber

  • Machine Learning Prediction of Cancer Cell Sensitivity to Drugs Based on Genomic and Chemical Properties

    Michael P. Menden;Francesco Iorio;Francesco Iorio;Mathew Garnett;Ultan McDermott

  • Pharmacogenomic agreement between two cancer cell line data sets

    Nicolas Stransky;Mahmoud Ghandi

  • MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling.

    Sidong Huang;Michael Hölzel;Theo Knijnenburg;Andreas Schlicker

  • Wild-Type and Mutant B-RAF Activate C-RAF through Distinct Mechanisms Involving Heterodimerization

    Mathew J. Garnett;Sareena Rana;Hugh Paterson;David Barford

  • A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds.

    Alejandra Bruna;Oscar M. Rueda;Wendy Greenwood;Ankita Sati Batra

  • ETV6-NTRK3 Gene Fusions and Trisomy 11 Establish a Histogenetic Link between Mesoblastic Nephroma and Congenital Fibrosarcoma

    S. R. Knezevich;M. J. Garnett;T. J. Pysher;J. B. Beckwith

  • Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance

    Maria Secrier;Xiaodun Li;Nadeera de Silva;Matthew D Eldridge

  • Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.

    Mia Petljak;Ludmil B Alexandrov;Jonathan S Brammeld;Stacey Price

  • Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

    Else Driehuis;Arne van Hoeck;Kat Moore;Sigrid Kolders

  • Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance (vol 48, pg 1131, 2016)

    Maria Secrier;Xiaodun Li;Nadeera de Silva;Matthew D Eldridge

Frequent Co-Authors

Ultan McDermott
Ultan McDermott AstraZeneca (United Kingdom)
Julio Saez-Rodriguez
Julio Saez-Rodriguez Heidelberg University
Cyril H. Benes
Cyril H. Benes Harvard University
Kosuke Yusa
Kosuke Yusa Kyoto University
Graham R. Bignell
Graham R. Bignell Wellcome Sanger Institute
Lodewyk F. A. Wessels
Lodewyk F. A. Wessels Antoni van Leeuwenhoek Hospital
Michael R. Stratton
Michael R. Stratton Wellcome Sanger Institute
Olivier Elemento
Olivier Elemento Cornell University
Wafik S. El-Deiry
Wafik S. El-Deiry Brown University
Daniel A. Haber
Daniel A. Haber Harvard University

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