2026 Kosuke Yusa: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Molecular Biology	46	2788	2529	208	187	101	11872

Overview

Kosuke Yusa is affiliated with Kyoto University in Japan and has contributed extensively to research in the fields of Biochemistry, Genetics, and Molecular Biology, with a particular focus on Molecular Biology and Oncology. Their work spans 54 publications in the broader field and includes 31 in Medicine.

Their research covers topics central to genetic engineering and cancer biology, with significant contributions related to CRISPR and Genetic Engineering, Protein Degradation and Inhibitors, Pluripotent Stem Cells Research, and Acute Myeloid Leukemia Research. Additional emphasis includes Cancer Mechanisms and Therapy, Histone Deacetylase Inhibitors Research, and Genomics and Chromatin Dynamics.

CRISPR and Genetic Engineering
Protein Degradation and Inhibitors
Pluripotent Stem Cells Research
Acute Myeloid Leukemia Research
Cancer Mechanisms and Therapy
Histone Deacetylase Inhibitors Research
Genomics and Chromatin Dynamics

Yusa's recent published papers illustrate the scope and focus of their research interests. Selected works include:

"ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response" (2020), Nature Genetics
"Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions" (2020), Nature Communications
"Minimal genome-wide human CRISPR-Cas9 library" (2021), Genome Biology
"KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements" (2020), Leukemia
"Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain" (2022), Science Translational Medicine

The scientist collaborates frequently with a group of coauthors, several of whom have multiple joint publications. These include Yusuke Tarumoto, Kotaro Shirakawa, Akifumi Takaori-Kondo, Yoshihito Horisawa, and George S. Vassiliou.

Yusuke Tarumoto
Kotaro Shirakawa
Akifumi Takaori-Kondo
Yoshihito Horisawa
George S. Vassiliou

Yusa's work is frequently published in well-regarded venues, including Blood, bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Nature Genetics, and Nature Communications, with the highest number of contributions appearing in Blood and bioRxiv.

Blood
bioRxiv (Cold Spring Harbor Laboratory)
Cancer Research
Nature Genetics
Nature Communications

Best Publications

Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

Fiona M. Behan;Francesco Iorio;Francesco Iorio;Gabriele Picco;Emanuel Gonçalves

1317
Citations
Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

Hiroko Koike-Yusa;Yilong Li;E-Pien Tan;Martin Del Castillo Velasco-Herrera

1159
Citations
Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon

Kosuke Yusa;Roland Rad;Junji Takeda;Allan Bradley

785
Citations
A hyperactive piggyBac transposase for mammalian applications.

Kosuke Yusa;Liqin Zhou;Meng Amy Li;Allan Bradley

784
Citations
A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

Konstantinos Tzelepis;Hiroko Koike-Yusa;Etienne De Braekeleer;Yilong Li

783
Citations
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

Kosuke Yusa;S. Tamir Rashid;Helene Strick-Marchand;Helene Strick-Marchand;Ignacio Varela

783
Citations
Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes

Prashant Mali;Bin Kuan Chou;Jonathan Yen;Zhaohui Ye

524
Citations
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

Stephen J. Pettitt;Dragomir B. Krastev;Inger Brandsma;Amy Dréan

370
Citations
PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice

Roland Rad;Lena Rad;Wei Wang;Juan Cadinanos

274
Citations
A Genetic Progression Model of BrafV600E-Induced Intestinal Tumorigenesis Reveals Targets for Therapeutic Intervention

Roland Rad;Roland Rad;Roland Rad;Juan Cadiñanos;Lena Rad;Ignacio Varela

222
Citations
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets.

Joshua M. Dempster;Clare Pacini;Sasha Pantel;Fiona M. Behan

212
Citations
Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation

Johan Henriksson;Xi Chen;Tomás Gomes;Ubaid Ullah

204
Citations
Mobilization of giant piggyBac transposons in the mouse genome

Meng Amy Li;Daniel J. Turner;Zemin Ning;Kosuke Yusa

196
Citations
Characterization of Sleeping Beauty transposition and its application to genetic screening in mice.

Kyoji Horie;Kosuke Yusa;Kojiro Yae;Junko Odajima

183
Citations
ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Gabriel Balmus;Domenic Pilger;Julia Coates;Mukerrem Demir

157
Citations
Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system

Vincent W Keng;Kojiro Yae;Tomoko Hayakawa;Sumi Mizuno

140
Citations
ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

Sankari Nagarajan;Shalini V Rao;Shalini V Rao;Joseph Sutton;Danya Cheeseman

133
Citations
Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening.

Gabriele Picco;Elisabeth D. Chen;Luz Garcia Alonso;Fiona M. Behan

111
Citations
Hyperactive piggyBac gene transfer in human cells and in vivo.

Joseph E. Doherty;Leslie E. Huye;Kosuke Yusa;Liqin Zhou

108
Citations
Genome-wide CRISPR screens in T helper cells reveal pervasive cross-talk between activation and differentiation

Johan Henriksson;Xi Chen;Tomás Gomes;Ubaid Ullah

3
Citations

Frequent Co-Authors

Mathew J. Garnett Wellcome Sanger Institute

Allan Bradley University of Cambridge

Junji Takeda Osaka University

George S. Vassiliou University of Cambridge

Ultan McDermott AstraZeneca (United Kingdom)

Julio Saez-Rodriguez Heidelberg University

Roland Rad Technical University of Munich

Leopold Parts Wellcome Sanger Institute

Fengtang Yang Wellcome Sanger Institute

David J. Adams Wellcome Sanger Institute

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