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David A. Largaespada

David A. Largaespada

D-Index & Metrics

Genetics

D-Index
76
Citations
34694
World Ranking
1795
National Ranking
823

Overview

David A. Largaespada is affiliated with the University of Minnesota in the United States. Their research activity spans fields related to Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Neurology, Oncology, Pulmonary and Respiratory Medicine, and Genetics as key subfields.

Their recent research contributions include a range of publications spanning experimental and clinical studies. Among these are:

  • APOBEC3A catalyzes mutation and drives carcinogenesis in vivo (2020, The Journal of Experimental Medicine)
  • Epigenomic, genomic, and transcriptomic landscape of schwannomatosis (2020, Acta Neuropathologica)
  • ZBTB20 regulates WNT/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis (2020, JHEP Reports)
  • New Model Systems and the Development of Targeted Therapies for the Treatment of Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors (2020, Genes)
  • Cdkn2a Loss in a Model of Neurofibroma Demonstrates Stepwise Tumor Progression to Atypical Neurofibroma and MPNST (2020, Cancer Research)

David A. Largaespada's work has been published consistently in several frequent venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology
  • Cancer Research
  • International Journal of Molecular Sciences
  • Journal of Investigative Dermatology

The scientist collaborates regularly with several coauthors, including:

  • Kyle Williams
  • Alex T. Larsson
  • Branden S. Moriarity
  • Christopher L. Moertel
  • Tyler Jubenville

Their main topics of work involve investigations into:

  • Neurofibromatosis and Schwannoma Cases
  • Sarcoma Diagnosis and Treatment
  • Neuroblastoma Research and Treatments
  • CRISPR and Genetic Engineering
  • CAR-T cell therapy research
  • Glioma Diagnosis and Treatment
  • Protein Degradation and Inhibitors

David A. Largaespada's research outputs reflect contributions to the understanding and development of treatments for neurological cancers and genetic disorders, supported by ongoing collaborations and publications in medical and molecular biology domains. Their expertise spans both fundamental molecular mechanisms as well as clinical oncology topics.

Best Publications

  • Pluripotency of mesenchymal stem cells derived from adult marrow

    Yuehua Jiang;Balkrishna N. Jahagirdar;R. Lee Reinhardt;Robert E. Schwartz

  • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

    Andrew V. Biankin;Andrew V. Biankin;Andrew V. Biankin;Nicola Waddell;Karin S. Kassahn;Marie Claude Gingras

  • Exome sequencing identifies frequent mutation of the SWI/SNF Complex Gene PBRM1 in renal carcinoma

    Ignacio Varela;Patrick Tarpey;Keiran Raine;Dachuan Huang

  • Recurrent R-spondin fusions in colon cancer

    Somasekar Seshagiri;Eric W. Stawiski;Steffen Durinck;Zora Modrusan

  • Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

    David J. Rawlings;Douglas C. Saffran;Satoshi Tsukada;David A. Largaespada

  • Lymphotactin: a cytokine that represents a new class of chemokine

    Gregory S. Kelner;Jacqueline Kennedy;Kevin B. Bacon;Sarah Kleyensteuber

  • PVT1 dependence in cancer with MYC copy-number increase

    Yuen Yi Tseng;Branden S. Moriarity;Wuming Gong;Ryutaro Akiyama

  • Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

    Takuro Nakamura;David A. Largaespada;Maxwell P. Lee;Laura A. Johnson

  • Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system

    Adam J. Dupuy;Keiko Akagi;David A. Largaespada;Neal G. Copeland

  • Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells

    Partow Kebriaei;Harjeet Singh;M. Helen Huls;Matthew J. Figliola

  • Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor.

    Linda S. Park;Unja Martin;Kirsten Garka;Brian Gliniak

  • Clonal selection drives genetic divergence of metastatic medulloblastoma

    Xiaochong Wu;Paul A. Northcott;Adrian Dubuc;Adam J. Dupuy

  • Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

    Lara S. Collier;Corey M. Carlson;Shruthi Ravimohan;Shruthi Ravimohan;Adam J. Dupuy;Adam J. Dupuy

  • Gene Transfer into Genomes of Human Cells by the Sleeping Beauty Transposon System

    Aron M Geurts;Ying Yang;Karl J Clark;Geyi Liu

  • A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer

    Timothy K. Starr;Raha Allaei;Kevin A. T. Silverstein;Rodney A. Staggs

  • Divergent clonal selection dominates medulloblastoma at recurrence

    A. Sorana Morrissy;Livia Garzia;David J.H. Shih;Scott Zuyderduyn

  • Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

    Takuro Nakamura;David A. Largaespada;John D. Shaughnessy;Nancy A. Jenkins

  • Harnessing a high cargo-capacity transposon for genetic applications in vertebrates.

    Darius Balciunas;Kirk J Wangensteen;Andrew Wilber;Jason Bell

  • Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia.

    David A. Largaespada;Camilynn I. Brannan;Nancy A. Jenkins;Neal G. Copeland

  • Erratum: Pluripotency of mesenchymal stem cells derived from adult marrow (Nature (2002) 418 (41-49) DOI: 10.1038/nature00870)

    Yuehua Jiang;Balkrishna N. Jahagirdar;R. Lee Reinhardt;Robert E. Schwartz

Frequent Co-Authors

Neal G. Copeland
Neal G. Copeland The University of Texas MD Anderson Cancer Center
Nancy A. Jenkins
Nancy A. Jenkins The University of Texas MD Anderson Cancer Center
Perry B. Hackett
Perry B. Hackett University of Minnesota
Nancy Ratner
Nancy Ratner Cincinnati Children's Hospital Medical Center
R. Scott McIvor
R. Scott McIvor University of Minnesota
Kevin Shannon
Kevin Shannon University of California, San Francisco
Aron M. Geurts
Aron M. Geurts Medical College of Wisconsin
David J. Adams
David J. Adams Wellcome Sanger Institute
Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center
Andrew V. Biankin
Andrew V. Biankin University of Glasgow

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